Anthim (obiltoxaximab) is a monoclonal antibody that binds the PA of B. anthracis.
Anthim is specifically indicated for use in adult and pediatric patients for the treatment of inhalational anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs and for prophylaxis of inhalational anthrax due to B. anthracis when alternative therapies are not available or not appropriate.
Anthim is supplied as an injection for intravenous administration. The recommended dose is as follows:
As it is not feasible or ethical to conduct controlled clinical trials in humans with inhalational anthrax, the efficacy of Anthim for the treatment of inhalational anthrax was based on efficacy studies in NZW rabbits and cynomolgus macaques. Anthim monotherapy administered as a single 16 mg/kg IV dose for the treatment of inhalational anthrax disease resulted in statistically significant improvement in survival relative to placebo in two studies for each species. Anthim administered in combination with antibacterial drugs (levofloxacin, ciprofloxacin and doxycycline) for the treatment of systemic inhalational anthrax disease resulted in higher survival outcomes than antibacterial therapy alone in multiple studies where Anthim and antibacterial therapy was given at various doses and treatment times. Anthim administered as prophylaxis resulted in higher survival outcomes compared to placebo in multiple studies where treatment was given at various doses and treatment times.
Adverse effects associated with the use of Anthim may include, but are not limited to, the following:
Anthim comes with a black box warning of hypersensitivity reactions, including anaphylaxis, have been reported during Anthim infusion
Anthim (obiltoxaximab) is a monoclonal antibody that binds free PA with an affinity equilibrium dissociation constant (Kd) of 0.33 nM. Obiltoxaximab inhibits the binding of PA to its cellular receptors, preventing the intracellular entry of the anthrax lethal factor and edema factor, the enzymatic toxin components responsible for the pathogenic effects of anthrax toxin.
For additional information regarding Anthim or anthrax infection, please visit http://anthim.com/