Are feelings of fear, isolation, and vulnerability keeping you from what matters most?

Am I Eligible?

About The CYPRESS Study

The CYPRESS study is a clinical research study for adults who have post-traumatic stress disorder, otherwise known as PTSD. In this study, doctors are evaluating an investigational drug when it is combined with Sertraline, an antidepressant that’s approved in the United States for the treatment of PTSD.

The investigational drug in this study is approved in the United States for the treatment of schizophrenia and as an adjunctive therapy for major depressive disorder (MDD). However, it has not been approved to treat PTSD.

The results of this study will provide more information about any potential benefits of this treatment combination for people with PTSD.

If you or someone you know has PTSD or is showing symptoms, we invite you to learn more about the CYPRESS study and PTSD.

Why Is The CYPRESS Study Being Conducted?

According to research, only 25-60% of people with PTSD respond to available treatment options. As a result, there are many people who struggle with their symptoms and often feel like they’re facing the disorder alone.

Because so many patients have little to no success with their treatment, there is a need to research and develop additional treatment options for PTSD. The CYPRESS study will allow doctors to better understand the safety and effectiveness of the investigational drug when it is combined with Sertraline.

What Happens In The CYPRESS Study?

In this study, eligible patients could receive one of the following treatment combinations:

  • Investigational drug + Sertraline
  • Sertraline + placebo
  • Placebo + placebo

Placebo looks like the investigational drug or Sertraline but contains no active drug. All patients will take their study drugs once a day for 12 weeks.

Patients will also be asked to visit the study clinic up to 11 times. During study clinic visits, the study doctors and staff will evaluate patients’ overall health and PTSD symptoms through various tests and assessments.

Total participation in this study will last approximately 17 weeks.

What Do PTSD Symptoms Look Like?

PTSD usually develops after someone has experienced or witnessed a traumatic event. After the trauma occurs, a person may:

  • Have unwanted memories of the event
  • Struggle with fear and anxiety
  • Feel isolated from family and friends
  • Avoid situations that remind them of the trauma

To be in this study, patients need to have shown PTSD symptoms for at least 6 months prior to joining the study.

If you’ve experienced or witnessed a traumatic event and now have unwanted memories of the event, struggle with fear and anxiety, feel isolated from family and friends; or avoid situations that remind you of the trauma, you may have post-traumatic stress disorder (PTSD).