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Found 31 clinical trials
Desomumab vs Zoledronic Acid and Osteoporotic Compression Fracture

Bone mineral density and function at 1 year after screw fixation with desomumab vs zoldronic acid for osteoporotic vertebral compression fractures: a parallel double-blind randomized controlled clinical trial

Accepts healthy volunteers
  • 11 Nov, 2021
  • 1 location
Delayed Versus Immediate Use Of Zoledronic Acid For Postmenopausal Patients With Early Breast Cancer Who Are Using Adjuvant Letrozole

The investigators will involve about 25 Patients of postmenopausal women who have ER/PR positive early breast cancer in each arm. The study is a two-arm comparative, prospective, interventional, and randomized study. All patients who are on oral daily letrozole (2.5 mg), will be randomly assigned to receive either immediate or …

  • 31 Dec, 2021
  • 1 location
Zoledronic Acid as Adjuvant Therapy in Neovascular Age-related Macular Degeneration (Z-AMD) (Z-AMD)

A pilot study of zoledronic acid as adjuvant therapy to standard anti-vascular endothelial growth factor (anti-VEGF) treatment for neovascular age-related macular degeneration (AMD).

  • 24 Mar, 2022
  • 2 locations
Trochanteric Femur Fracture Operated With Dynamic Hip Screw System (DHS) Augmented With a Biphasic Apatite Sulphate Combined With Systemic or Local Bisphosphonate

The purpose of this study is to study the process of bone regeneration around a metal device in the femoral neck canal using a synthetic bone substitute Cerament bone void filler (BVF) and bisphosphonate (Zometa) locally or systemically that affects bone metabolism. Furthermore, fracture healing and implant migration will be …

  • 25 Mar, 2022
  • 1 location
Trial of Parkinson's And Zoledronic Acid (TOPAZ)

This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older

screening procedures
zoledronic acid
supranuclear palsy
Accepts healthy volunteers
  • 12 May, 2022
  • 53 locations
Zoledronate in Preventing Skeletal (Bone)-Related Events in Patients Who Are Receiving Androgen Deprivation Therapy For Prostate Cancer and Bone Metastases

This research study is being done to find out if giving zoledronic acid before the cancer spreads to the bone is better or worse than standard treatment. The study will also compare the

zoledronic acid
bone metastases
  • 07 Nov, 2020
  • 1 location
Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks

The aim of the trial is to test the hypothesis that the benefit of denosumab is maintained if administered only every 12 weeks as compared to every 4 weeks.

ct scan
breast cancer
bone metastases
  • 21 Apr, 2022
  • 62 locations
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE)

The overall aim of this trial, which is called STAMPEDE, is to assess novel approaches for the treatment of men with prostate cancer who are starting long-term ADT for the first time, termed hormone-naïve prostate cancer. This trial aims to see if we can improve the way in which prostate …

zoledronic acid
adenocarcinoma of prostate
neutrophil count
hormone therapy
  • 04 May, 2022
  • 115 locations
Efficacy of Zoledronic Acid in Osteoporosis

There has been no comparative data between Zoledronic acid and Zoledronic acid combined with active vitamin D in primary and secondary osteoporosis.

zoledronic acid
secondary osteoporosis
vitamin d
  • 31 Jan, 2022
  • 1 location
Treatment of Osteogenesis Imperfecta With Parathyroid Hormone and Zoledronic Acid

infusion of zoledronic acid (ZA) in adults with OI reduces the proportion of patients who experience a fracture as compared with standard care Adult patients with a clinical diagnosis of OI who are

parathyroid hormone
zoledronic acid
bone mineral density
care adult
  • 22 Jan, 2021
  • 25 locations