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Found 67 clinical trials
Aesthetic Outcome of Layered Closure vs. Layered Closure Followed by 2-Octyl Cyanoacrylate

Following skin surgeries on the head and neck, several surgeons use a type of surgical glue (such as Dermabond) as a final layer on the top of wound. This glue is thought to seal the wound. Up until this point, there is limited data about the exact advantages or disadvantages …

dermatologic surgery
  • 07 Oct, 2022
  • 1 location
The Impact of a Pluridisciplinary Education Program on Venous Leg Ulcer Size Reduction (vened)

Background and rationale: Venous leg ulcers (VLU) are slow healing wounds with a recurrence rate of 70% and a 60% risk of becoming chronic. The estimated VLU prevalence in the general population is 3%. Current therapeutic approaches are multifaceted and focus on reducing wound size and improving wound healing as …

leg ulcer
  • 26 May, 2022
  • 3 locations
Minimal Invasive Volar Plating Versus Cast Immobilization for Treatment of Stable Non-displaced Distal Radial Fractures.

Nondisplaced distal radial fractures are nowadays treated by plaster cast immobilization. In this study, the investigators challenge this classical standard treatment with a surgical solution: minimal invasive volar plating with pronatus quadratus sparing approach. Potential benefits of this surgical treatment are higher cost effectiveness, economical benefit, earlier recuperation of professional …

Accepts healthy volunteers
  • 21 Oct, 2022
  • 1 location
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers

The investigators propose a Phase II study, prospective and placebo controlled, of a topical cream containing sodium nitrite compared to the current standard of care. Sodium nitrite is a local donor of nitric oxide, which is known to improve blood flow and decrease bacterial load in the ulcer bed. The …

leg ulcer
nitric oxide
  • 26 Apr, 2022
  • 2 locations
Subcutaneous Injections of Autologous ASC to Heal Digital Ulcers in Patients With Scleroderma.

Ischemic digital ulcers (DUs) are a frequent complication in systemic sclerosis with a major impact on hand function and quality of life. Digital injection of autologous cultured adipose-derived stromal constitutes a promising approach to treat scleroderma-induced refractory ischemic DUs where no alternative therapy is validated. The aim of this phase …

follicle stimulating hormone
progressive systemic sclerosis
digital ulcer
  • 25 Jan, 2021
  • 6 locations
Zinc Oxide Versus Petrolatum Following Skin Surgery

Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this split scar, head to head study comparing zinc oxide and petrolatum. Patients will …

topical zinc oxide
Accepts healthy volunteers
dermatologic surgery
  • 30 Apr, 2022
  • 1 location
Trauma Medical Home for Older Injured Patients

This proposal aims to conduct a randomized controlled trial to evaluate the efficacy of a 6-month collaborative care intervention in improving the functional and psychological recovery of 430 injury survivors 50 and older. The trial has the following specific aims: 1) Evaluate the ability of the TMH intervention to improve …

  • 22 Jan, 2021
  • 3 locations
A Study of Plurogel® Compared to Standard Topical Dressing in Burn Injuries

Burn injuries can result in long term physical and mental sequelae, not only from the scarring but also the painful dressings. The standard of care today remains use of antibiotic topical dressings while awaiting demarcation of the burn depth, with surgical excision and grafting for deep partial thickness and full …

  • 03 Jun, 2022
  • 1 location
Topical Oxygen Therapy for Diabetic Wounds

This is a pilot study which is intended to collect data to calculate an adequate sample size for a larger registered clinical trial. Eleven subjects were enrolled at The Ohio State University; we intend to enroll 29 more subjects at Indiana University. Due to the small sample size this study …

wound treatment
foot ulcer
wound dressing
wound care
  • 13 Mar, 2022
  • 1 location
Virtual Reality as a Distraction Technique for Performing Lumbar Punctures in Children and Young Adu

The goal of this feasibility study is to determine if Virtual Reality (VR) can be adequately used as an alternative to General Anesthesia (GA) for Lumbar Punctures (LP).

  • 04 Oct, 2022
  • 1 location