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Found 31 clinical trials
A Trial for Treatment of Cancer Patients With Multiple Brain Metastases Undergoing Whole-Brain Radiotherapy

This protocol is for a lead-in safety study of 5 patients followed by a randomized Phase 2 clinical trial of BMX-001, a new class of pharmaceutical, in 64 patients with multiple brain metastases (MBM) undergoing whole brain radiation therapy (WBRT). Preliminary studies have demonstrated that BMX-001 provides protection of normal …

  • 13 views
  • 15 Feb, 2021
  • 3 locations
Stereotactic Radiosurgery to the Resection Cavity Following Surgical Removal of Brain Metastasis

most important components in the management of BM with the goal to prolong survival and improve the quality of life. Whole brain radiotherapy (WBRT) has shown to increase local and distant

stereotactic radiosurgery
brain metastases
metastasis
karnofsky performance status
cancer
  • 12 views
  • 07 Nov, 2020
  • 1 location
RCT of the 4mm vs. the 8mm Collimator for GKR of Brain Micrometastases

control rate of 80%-90% following GKR (Chang, Lee et al. 2000; Da Silva, Nagayama et al. 2009; Salvetti, Nagaraja et al. 2013). There is controversy over the use of GKR and/or Whole Brain

  • 1 views
  • 21 Jan, 2021
  • 3 locations
EGFR-TKI Concurrent With/Without WBRT in Brain Metastasis From NSCLC

) harboring EGFR mutant type is not inferior to EGFR-TKI concurrent with whole brain radiotherapy (WBRT), the primary end point is intracranial PFS (iPFS), while secondary outcomes included overall survival

icotinib
gefitinib
metastasis
neutrophil count
EGFR
  • 12 views
  • 21 Jan, 2021
Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous System

maintenance therapy; the aim is to evaluate the efficacy of these two drugs. The more fragile patients will receive a less aggressive therapy consisting of concomitant whole-brain radiotherapy

maintenance treatment
methotrexate
cancer
temozolomide
whole-brain radiotherapy
  • 0 views
  • 31 Jan, 2021
  • 40 locations
Pivotal Open-label Randomized Study of Radiosurgery With or Without Tumor Treating Fileds (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC).

The study is a prospective, randomized controlled phase III trial, to test the efficacy, safety and neurocognitive outcomes of advanced NSCLC patients, following stereotactic radiosurgery (SRS) for 1-10 brain metastases, treated with NovoTTF-100M compared to supportive treatment alone. The device is an experimental, portable, battery operated device for chronic administration …

  • 0 views
  • 28 Jan, 2021
  • 122 locations
Supportive Care With or Without Repeated Whole Brain Radiotherapy in Patients With Recurrent Brain Metastases

Patients with solid cancers may develop cerebral metastases, requiring whole brain radiotherapy (WBRT). Furthermore, in several cases, a secondary course of WBRT might be required due to

metastasis
whole-brain radiotherapy
cancer
  • 0 views
  • 26 Jan, 2021
  • 1 location
Whole-Brain Radiotherapy (WBRT) Versus WBRT and Integrated Boost Using Helical Tomotherapy for Multiple Brain Metastases

patients survive prolonged periods with vigorous therapeutic approach. Specific therapeutic options are surgery, chemotherapy, conventional fractionated whole-brain radiotherapy (WBRT) and

whole-brain radiotherapy
solid neoplasm
primary tumor
metastasis
lung cancer
  • 11 views
  • 07 Nov, 2020
  • 4 locations
A Prospective Study of the Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Neurocognitive Function Decline

Whole brain radiotherapy (WBRT) has long been a practical and effective therapeutic modality for various settings of management in radiation oncology. For example, the indications for WBRT

whole-brain radiotherapy
brain tumor
metastasis
lung cancer
cancer
  • 8 views
  • 20 Mar, 2021
  • 1 location
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5-15 Brain Metastases

Stereotactic radiosurgery (SRS) is a commonly used treatment for brain tumors. It is a one-day (or in some cases two day), out-patient procedure during which a high dose of radiation is delivered to small spots in the brain while excluding the surrounding normal brain. Whole brain radiation therapy with hippocampal …

stereotactic radiosurgery
whole-brain radiotherapy
brain tumor
metastasis
cancer
  • 87 views
  • 15 Mar, 2021
  • 69 locations