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Found 42 clinical trials
Reduced Intensity BMT for Immune Dysregulatory and Bone Marrow Failure Syndromes Using Post-Transplant Cyclophosphamide

This is a Phase II prospective trial to assess the rates of donor engraftment using reduced intensity conditioning (RIC) hematopoietic stem cell transplant (HSCT) and post-transplant cyclophosphamide (PTCy) for patients with primary immune deficiencies (PID), immune dysregulatory syndromes (IDS), and inherited bone marrow failure syndromes (IBMFS).

immunoglobulin e
forced vital capacity
immune globulin
wiskott-aldrich syndrome
  • 24 Feb, 2022
  • 1 location
MIP Versus PCNL for Kidney Stone Disease

The decision to use standard percutaneous nephrolithotomy (PCNL) versus mini-percutaneous nephrolithotomy (MIP) has been a subject of much debate in the urological community. The investigators propose a randomized controlled trial to compare the operative outcomes and complications of mini-percutaneous nephrolithotomy (mini-PCNL) versus standard PCNL for renal stones. The results of …

  • 21 Jul, 2022
  • 5 locations
DCE-CT of Thoracic Tumors as an Early Biomarker for Treatment Monitoring in Comparison With Morphologic Criteria

DCE-CT of thoracic tumors as an early biomarker for treatment monitoring in comparison with morphologic criteria. Rationale of the clinical investigation For the evaluation of response to anti-tumoral therapy in thoracic tumors, merely morphologic information is often not sufficient for early response evaluation as dimensions of the oncologic lesions are …

  • 14 Feb, 2021
  • 1 location
Febrile Illness in Kinshasa and Kimpese (FIKI²)

laboratory analyses in the partners institutions and at the ITM. We aim as a new primary objective at describing the profile of different biomarkers (C-reactive protein and white blood cell count with

  • 23 Apr, 2022
  • 2 locations
Different Treatment Strategies on Prognosis of Acute Ischemic Stroke(AISDTS)

AISDTS is a prospective registry study, in which clinical information, examination and imaging data of patients with acute ischemic stroke receiving different treatment strategies were collected, grouped and statistically analyzed, and corresponding clinical prediction models were constructed to explore the role of clinical biological indicators in the occurrence and development …

  • 16 Jun, 2022
  • 1 location
Usefulness of White Blood Cell Count (WBCC) During Infection in Geriatric Patient

In the general population, increased WBCC and neutrophil count are widely used as markers for infection during inflammatory states 1. However, 32% of geriatric patients with an infection do not develop an increase in WBCC 2. The hypothesis is that with inflammation, geriatric patients have a misadapted response of the …

  • 16 Dec, 2021
  • 1 location
Increasing Insulin Resistance as a Predictor of Impending Bacteremia

the intensive care unit to diagnose the development of sepsis within the unit, such as an increase or decrease in body temperature, an increase in CRP level, white blood cell count, pro-calcitonin

  • 02 May, 2022
  • 1 location
Detection and Delineation of Necrotizing Fasciitis Via a Vascular Perfusion Fluorophore

The primary objective of this work is to determine if fluorescence signal intensity changes from a vascular perfusion fluorophore (indocyanine green) can be associated with the presence of necrotizing fasciitis. Hypothesis - Tissue regions affected with necrotizing fasciitis will demonstrate reduced fluorescence intensity compared to an unaffected region without clinical …

  • 10 Jul, 2022
  • 1 location
Periprosthetic Joint Infections: Diagnostic Accuracy and Cost-effectiveness Analysis of Serum and Synovial Markers (DECISION)

Total joint replacement (TJR) is an increasing effective procedure in orthopedics. However, TJR failure due to aseptic or septic loosening remains an important problem, often due to predisposing factors of the patient, which determine the need to perform a revision surgery. In light of the recent conclusions emerged on the …

  • 06 Apr, 2022
  • 1 location
Biomarkers in Infection

The purpose of this investigation is to evaluate how early biomarkers of infection and inflammation perform in identifying patients at risk for poor outcome in sepsis and septic shock.

leukocyte count
white blood cell count
septic shock
  • 23 Jan, 2021
  • 4 locations