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Found 266 clinical trials
featured
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Gene transfer is a new cancer therapy takes white blood cells from a person and grows them in a lab. The cells are changed with a virus to attack tumor cells, then returned to the person

clear cell renal cell carcinoma
primary cancer
renal cell cancer
metastatic cancer
carcinoma
  • 144 views
  • 22 Dec, 2020
  • 1 location
featured
Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Background: Chronic lymphocytic leukemia (CLL) is a cancer of white blood cells. It is also called small lymphocytic lymphoma (SLL). It causes tiredness, night sweats

TP53
anemia
lymphadenopathy
thrombocytopenia
lymphoma
  • 47 views
  • 23 Nov, 2020
  • 1 location
featured
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

, researchers are interested in developing new approaches to stem cell transplants that will reduce the likelihood of these complications. By reducing the number of white blood cells included in the

anemia studies
anemia
myelodysplastic syndromes
myelodysplastic syndrome (mds)
aplastic anemia
  • 86 views
  • 22 Dec, 2020
  • 1 location
featured
Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives

recognized by transplanted white blood cells (lymphocytes). These lymphocytes begin attacking the recipient s cells and tissues and may lead to death. In order to avoid GVHD, researchers have developed

  • 194 views
  • 22 Dec, 2020
  • 1 location
featured
Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which suppress the immune system and stop it from

anemia studies
anemia
myelodysplastic syndromes
myelodysplastic syndrome (mds)
aplastic anemia
  • 123 views
  • 22 Dec, 2020
  • 1 location
featured
Haplo-identical Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using Peripheral Blood Stem Cells and Post-Transplant Cyclophosphamide for GVHD Prophylaxis

separate stem cells and maybe white blood cells. The rest of the blood will be returned into the other arm or leg. In the hospital for about 1 month, recipients will have: Central line

anemia studies
anemia
myelodysplastic syndromes
myelodysplastic syndrome (mds)
aplastic anemia
  • 57 views
  • 22 Dec, 2020
  • 1 location
featured
A Randomized Trial of Sirolimus (Rapamune) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Background: People with severe aplastic anemia (SAA) do not make enough red and white blood cells, and/or platelets. Their body's immune system stops the bone marrow

anemia studies
anemia
myelodysplastic syndromes
myelodysplastic syndrome (mds)
aplastic anemia
  • 61 views
  • 22 Dec, 2020
  • 1 location
featured
COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 - Australia  

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept (ACE-536) …

erythropoietin
epoetin alfa
vasectomy
cancer
  • 53 views
  • 05 Jan, 2021
  • 7 locations
featured
COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 - US  

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.   This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept …

erythropoietin
epoetin alfa
vasectomy
cancer
  • 5134 views
  • 07 Jan, 2021
  • 13 locations
Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia

. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the

cell transplantation
granulocyte colony stimulating factor
white blood cell count
cytarabine
cyclosporine
  • 12 views
  • 04 Aug, 2019
  • 5 locations