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Found 42 clinical trials
Efficacy of Intravenous In-line Filter in Patient Undergoing Cardiac Surgery

The aim of this study is to demonstrated efficacy of in-line filtration to reduce systemic inflammatory response syndrome (SIRS) ,specific organ dysfunction and complications in adult cardiac surgery. 486 patients undergoing cardiac surgery for acquired heart disease are 1:1 randomized into in-line filtration (study group) and non-filtration (control group). The …

heart surgery
organ failure
  • 0 views
  • 24 Jan, 2021
  • 1 location
Use of Recombinant Human Lactoferrin in Long-Term Care Patients With Feeding Tubes With Clostridium Difficile.

Primary objective of this pilot study is to evaluate the effect of recombinant human lactoferrin on the rate of infection with Clostridium difficile in long-term care patients supported by enteral feeding requiring broad spectrum antibiotics.

  • 1 views
  • 07 Nov, 2020
  • 1 location
Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities

The objectives of this Phase 1 study are to evaluate the safety and feasibility of methylene-blue-mediated photodynamic therapy (MB-PDT) performed at the time of abscess drainage to treat deep tissue abscesses. Safety will be evaluated by physical examination and imaging and laboratory studies in order to identify adverse events that …

drainage
methylene
cavities
  • 2 views
  • 24 Jan, 2021
  • 1 location
Topical Vancomycin Over Sternal Edge in Cardiac Surgery

This is a single-blind 1:1 randomized controlled trial based on the hypothesis that topical application of vancomycin paste over sternum edge is safe and can reduce sternal wound infection after elective cardiac surgery. Vancomycin paste will be prepared using 2.5 g of vancomycin mixed with 2 ml normal saline. Vancomycin …

  • 0 views
  • 25 Jan, 2021
  • 1 location
Risk-adapted Therapy for Primary Acute Myeloid Leukemia

The AML-12 study investigates the efficacy and toxicity of standard induction chemotherapy with idarubicin and cytarabine (IC) with G-CSF priming followed by a risk-adapted post remission therapy for patients up to the age of 70 diagnosed with de novo acute myeloid leukemia (AML). Modifications from the previous protocol AML-03 (NCT01723657) …

  • 0 views
  • 04 Jan, 2021
  • 15 locations
Blue Light Therapy in Reducing Inflammation During Sepsis

. The outcome of interest is change in the inflammatory response after surgery for appendicitis or diverticulitis as measured by the following parameters: white blood cell count, heart rate, the

pneumonia
critical illness
a 12
colon resection
diverticulitis
  • 119 views
  • 24 Jan, 2021
  • 1 location
Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma

BCMA on their surface. Giving chemotherapy before BCMA CAR-T cells may reduce the amount of disease and to cause a low lymphocyte (white blood cell) count in the blood, which may help the infused BCMA

plasma cell leukemia
leukemia
progressive disease
cancer
immunomodulatory imide drug
  • 15 views
  • 25 Jan, 2021
  • 1 location
Methylprednisolone Horse Anti-Thymocyte Globulin Cyclosporine Filgrastim and/or Pegfilgrastim or Pegfilgrastim Biosimilar in Treating Patients With Aplastic Anemia or Low or Intermediate-Risk Myelodysplastic Syndrome

. This may help to fight infections and help improve the white blood cell count. Giving methylprednisolone and horse anti-thymocyte globulin together with cyclosporine, filgrastim, and/or pegfilgrastim

cyclosporine
cytopenia
methylprednisolone
horse anti-thymocyte globulin
aplastic anemia
  • 34 views
  • 10 Dec, 2020
  • 2 locations
Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma

the side effect of febrile neutropenia. Febrile neutropenia is a very low white blood cell count and a fever, which can be life threatening. Parts B and C will use drug combination of

vinblastine
colony stimulating factor
nivolumab
doxorubicin
classical hodgkin lymphoma
  • 44 views
  • 19 Dec, 2020
  • 38 locations
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS

neutropenia. Objectives To evaluate whether Mozobil is safe and effective to treat neutropenia (low white blood cell count) in patients with WHIMS

neutrophil count
colony stimulating factor
norplant
warts
cancer
  • 67 views
  • 16 Dec, 2020
  • 1 location