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Found 34 clinical trials
The Role of Meningeal Lymphatic Vessels in the Absorption of Chronic Subdural Hematoma and Its Injury Mechanism

Chronic subdural hematoma (CSDH) is a very common hemorrhagic disease of the nervous system, accounting for about 10% of hemorrhagic strokes. The incidence rate of elderly people over 65 years old is 58.1/100,000, and the incidence rate is increasing year by year, and it may reach 121/100,000 by 2030. At …

Accepts healthy volunteers
  • 0 views
  • 07 Jul, 2022
  • 1 location
Efficacy of Clopidogrel on Incidence of Silent Brain Infarction (ECISBI)

Silent brain infarctions (SBIs) are a manifestation of covert cerebrovascular disease, without obvious clinical deficit, noted very often in patients presenting with a new stroke or new transient ischemic attack. SBIs are linked to a significant increase in risk for subsequent stroke and cognitive decline. However, no biomarker is currently …

  • 0 views
  • 22 Apr, 2022
  • 1 location
Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities

The objectives of this Phase 1 study are to evaluate the safety and feasibility of methylene-blue-mediated photodynamic therapy (MB-PDT) performed at the time of abscess drainage to treat deep tissue abscesses. Safety will be evaluated by physical examination and imaging and laboratory studies in order to identify adverse events that …

cavities
drainage
methylene
  • 26 views
  • 05 Apr, 2022
  • 1 location
Topical Vancomycin Paste Over Sternal Edge: Safety and Effect of on Incidence of Sternal Wound Infection After Cardiac Surgery

This is a single-blind 1:1 randomized controlled trial based on the hypothesis that topical application of vancomycin paste over sternum edge is safe and can reduce sternal wound infection after elective cardiac surgery. Vancomycin paste will be prepared using 2.5 g of vancomycin mixed with 2 ml normal saline. Vancomycin …

  • 0 views
  • 19 Oct, 2022
  • 1 location
Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children. The cancer comes from a cell in the blood called a lymphocyte. Normal lymphocytes are produced in the bone marrow (along with other blood cells) and help fight infections. In ALL, the cancerous lymphocytes are called lymphoblasts. They …

asparaginase
mercaptopurine
doxorubicin
cyclophosphamide
adult t-cell leukemia/lymphoma
  • 26 views
  • 20 Jun, 2022
  • 9 locations
Blue Light Therapy in Reducing Inflammation During Sepsis

. The outcome of interest is change in the inflammatory response after surgery for appendicitis or diverticulitis as measured by the following parameters: white blood cell count, heart rate, the

sepsis
colon resection
a 12
critical illness
appendectomy
  • 119 views
  • 10 Mar, 2022
  • 1 location
A Phase I Study of MozobilTM in the Treatment of Patients With WHIMS

neutropenia. Objectives To evaluate whether Mozobil is safe and effective to treat neutropenia (low white blood cell count) in patients with WHIMS

cervical cap
mozobil
AIDS
neutrophils
depo-provera
  • 112 views
  • 10 Oct, 2022
  • 1 location
A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

their white blood cell count. This will be a shot or injection under the skin. Participants will recover in the hospital for 1-2 weeks. They will have lab and blood tests. Participants

filgrastim
cyclophosphamide
systemic therapy
antibiotic
immunoglobulin
  • 31 views
  • 20 Oct, 2022
  • 1 location
A Phase I Study of HERV-E TCR Transduced Autologous T Cells in Patients With Metastatic Clear Cell Renal Cell Carcinoma

tube) inserted into a vein in the chest. Get the changed cells via catheter. Get a drug to increase white blood cell count and one to make the cells active. Recover for

cancer
clear cell renal cell carcinoma
platelet count
chemotherapy drugs
hepatitis b antigen
  • 73 views
  • 18 Oct, 2022
  • 1 location
Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

This phase I trial finds the best dose and side effects of venetoclax in combination with cladribine, cytarabine, granulocyte colony-stimulating factor, and mitoxantrone (CLAG-M) in treating patients with acute myeloid leukemia and high-grade myeloid neoplasms. Venetoclax may stop the growth of cancer cells by blocking Bcl-2, a protein needed for …

ejection fraction
cancer
blast cells
colony stimulating factor
venetoclax
  • 0 views
  • 13 May, 2022
  • 1 location