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Found 10 clinical trials
Intravesical Lactobacillus for Urinary Symptoms Among People With NLUTD Who Use Indwelling Catheters

The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine ecosystem; and 2) to determine the optimal intravesical Lactobacillus RhamnosusGG (LGG®) dose to be used …

urinary symptoms
  • 0 views
  • 03 Jul, 2022
  • 1 location
Intravesical Lactobacillus to Reduce Urinary Symptoms After Spinal Cord Injury

The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine ecosystem; and 2) to determine the optimal intravesical Lactobacillus RhamnosusGG (LGG®) dose to be used …

spinal cord
spinal cord disorder
intermittent catheterization
neurogenic bladder
urinary symptoms
  • 42 views
  • 11 Oct, 2022
  • 1 location
Intravesical Lactobacillus rhamnosusGG Versus Saline Bladder Wash: A Randomized, Controlled, Comparative Effectiveness Clinical Trial

This is the first ever comparative effectiveness study of an antibiotic-sparing novel self-management intervention to prevent complicated urinary tract infection (UTI).

antibiotics
  • 0 views
  • 19 Oct, 2022
  • 1 location
Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients

The aim of the current pilot study proposal is to compare the use of the purified human fibrinogen concentrate (Fibryga, Octapharma USA) to cryoprecipitate for the treatment of cardiopulmonary bypass (CPB)-associated bleeding in pediatric cardiac patients in whom fibrinogen supplementation is indicated. The investigators' hypothesis is that fibrinogen concentrate will …

haemostasis
fibrinogen
cardiopulmonary bypass
cryoprecipitate
  • 0 views
  • 03 Nov, 2021
  • 1 location
CD22 Redirected Autologous T Cells for ALL

This is a single center, single arm, open-label pilot study to determine the feasibility and safety of a single dose administered as spilt fractions of autologous T cells expressing CD22 chimeric antigen receptors expressing tandem TCRζ and 4-1BB (TCRζ/4-1BB) co-stimulatory domains (referred to as "CART22" cells) in pediatric patients with …

central nervous system disease
direct bilirubin
alt/ast
cell therapy
tyrosine
  • 5 views
  • 25 Mar, 2022
  • 1 location
Extracorporal Photopheresis With UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease

This is a single arm phase 2 trial which includes patients with high risk acute GVHD defined as Ann Arbor score 2 or 3. The purpose of the study is to improve the outcome of these patients in terms of response to treatment and treatment related mortality. All patients will …

  • 0 views
  • 10 Oct, 2021
  • 3 locations
Identification of Molecular Marker of Coagulase-negative Staphylococci for the Diagnosis of Prosthetic Joint Infections

One of the major causes of prosthetic joint failure is infection. Recently, coagulase-negative Staphylococci (CoNS) have been identified as emergent, nosocomial pathogens involved in subclinical prosthetic joint infections (PJIs). The diagnosis of PJIs mediated by CoNS is complex and demanding due to the absence of clear clinical signs derived from …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Antibiotic Dosing in Geriatric Patients at the Emergency Department (AGED)

In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Amoxicilline-Clavulanate, Piperacillin-Tazobactam and Temocillin) are attained in frail patients admitted to the geriatric department.

piperacillin-tazobactam
hemoculture
antibiotics
lactam antibiotics
piperacillin
  • 0 views
  • 24 Mar, 2022
  • 1 location
Myocardial Injury Following Non-cardiac Surgery (EMINENT)

It is estimated that > 200 million patients in the world undergo surgery each year of which approximately 10 million will suffer from a myocardial injury in the perioperative period. Mortality is high in patients with myocardial injury since it often goes undiagnosed and management is unclear. In contrast to …

myocardial infarction
artery disease
infarct
troponin
heart surgery
  • 1 views
  • 03 Jun, 2022
  • 1 location
Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension

In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the mortality associated with fluid overload. The parameters and methodology used for assessing fluid responsiveness have been …

resuscitation
liver disease
systolic blood pressure
  • 0 views
  • 06 Jun, 2022
  • 2 locations