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Found 25 clinical trials
Acute Promyelocytic Leukemia 2006 (APL)

To assess the role of Arsenic trioxide and/or ATRA during consolidation course in APL. It is hoped that the investigational arms will further increase the event-free survival at 2 years, with reduced toxicity and without increasing the relapse rate by comparison with a classical anthracycline-AraC consolidation regimen.

tretinoin
anthracyclines
idarubicin
arsenic
  • 13 views
  • 07 Nov, 2020
  • 1 location
C Difficile Near-patient Diagnostics

The investigators will conduct a two-period, two-intervention, cluster randomized crossover (CRXO) designed study at Foothills Hospital. Each cluster (hospital ward) will receive each of the two interventions in a separate 6-month period of time leading to two "cluster-periods" with associated "wash-in" and "wash-out" periods attached. The two interventions are: 1) …

  • 0 views
  • 23 Jan, 2021
  • 2 locations
AIDA2000 - Risk-Adapted Therapy for Patients With Acute Promyelocytic Leukemia

In AIDA 2000 therapy of acute promyelocytic leukemia (APL) is given in a risk-adapted manner. Risk factors are age and white-blood-cell (WBC)-count at diagnosis. Induction therapy is done

consolidation therapy
retinoids
tretinoin
mitoxantrone
idarubicin
  • 40 views
  • 07 Nov, 2020
  • 1 location
High-dose Vitamin D Supplements in Older Adults

This Phase II randomized clinical trial aims to test if supplementation with high dose oral vitamin D will successfully correct vitamin D insufficiency, compared to treatment with standard (RDA) dose vitamin D in a diverse community-based elderly cohort. The effect of high-dose vs. standard-dose vitamin D on altering cognitive trajectories …

  • 0 views
  • 23 Nov, 2020
  • 1 location
Prospective Randomized Clinical Trial on Oral and Intravenous Antibiotic Prophylaxis in Colorectal Surgery.

Elective colon surgery is considered a clean-contaminated procedure, with a Surgical Site Infection (SSI) rate not inferior to 10%. For many years the role of Mechanical Bowel Preparation (MBP) has been universally recognized as an effective measure to reduce colonic bacterial load and consequently SSI rate, mostly in European Countries. …

antibiotic therapy
wound infection
colon surgery
anesthesia
sigmoidectomy
  • 0 views
  • 10 May, 2021
  • 1 location
Daunorubicin and Cytarabine With or Without Uproleselan in Treating Older Adult Patients With Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy

This phase II/III trial studies how well daunorubicin and cytarabine with or without uproleselan works in treating older adult patients with acute myeloid leukemia receiving intensive induction chemotherapy. Drugs used in chemotherapy, such as daunorubicin and cytarabine, work in different ways to stop the growth of cancer cells, either by …

acute leukemia
induction chemotherapy
cancer
blast cells
cytarabine
  • 25 views
  • 26 Jul, 2021
  • 105 locations
Post Implantation Syndrome and Administration on NSAIDs in Patients Undergoing EVAR for AAA

condition associated with the implantation of an endograft and is diagnosed by the presence of fever accompanied by elevated WBC count above normal without any evidence of an infection. The

aortic aneurysm
interleukin-6
  • 7 views
  • 22 Jan, 2021
  • 1 location
Treatment of Newly Diagnosed High Risk Acute Lymphoblastic Leukemia in Children

Treatment of pediatric acute lymphoblastic leukemia (ALL) has advanced and the overall survival exceeds 80% nowadays. However the overall survival of high risk ALL remains 75-90%, thus recent studies focus on treatment intensification according to the risk group. According to the previous reports, we designed a multicenter prospective trial for …

lymphoid leukemia
childhood all
blood cell count
b-cell acute lymphoblastic leukemia
methotrexate
  • 8 views
  • 21 Jan, 2021
Intravesical Lactobacillus for Urinary Symptoms Among People With NLUTD Who Use Indwelling Catheters

The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine ecosystem; and 2) to determine the optimal intravesical Lactobacillus RhamnosusGG (LGG) dose to be used …

urinary symptoms
  • 0 views
  • 22 Jun, 2021
  • 1 location
A Pilot Study to Evaluate the Safety and Activities of EW02 in Reducing Neutropenia Caused by Chemotherapy

Study Hypothesis: EW02 is a polysaccharide-enriched crude extract from black soybean (BS). BS has been used extensively by the Chinese as food or traditional Chinese medicine for hundreds of years. It has been used as monotherapy to treat Diabetes, menorrhagia and leukorrhea. In combination with others, BS has been used …

chemotherapy regimen
doxorubicin
cancer
cancer chemotherapy
white blood cell count
  • 14 views
  • 07 Nov, 2020
  • 1 location