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Found 7 clinical trials
Evaluation of the Safety,Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

will repeat some of the screening tests during the study. Participants will complete 6-minute walk tests to measure mobility and function. They will have transthoracic echocardiograms to measure

blood transfusion
a hemoglobin
absolute neutrophil count
platelet count
  • 27 Oct, 2022
  • 1 location
Xeomin® and Gait Related Mobility After Stroke

The aim of the present pilot study is to evaluate the association between change in gait related mobility in ambulatory male and female adult hemiparetic patients before and 4-6-weeks after Xeomin® injection into the upper limb, using two standardized tests of physical function in outpatient rehabilitation that are widely used; …

  • 11 May, 2022
  • 1 location
Increasing Physical Activity in COPD Through Rhythmically Enhanced Music

The VA cares for nearly one million Veterans with COPD at a cost of more than $5.5 billion annually. COPD profoundly impairs quality of life as it limits ability to work, to maintain physical exertion and to engage in social activities. Hospital-based rehab can decrease the need for inpatient and …

  • 12 Mar, 2022
  • 1 location
Comparison of the 1-min Sit-to-Stand Test to the 6-minute Walk Test in the Respiratory Functional Assessment of Pulmonary Fibrosis: a Cross-over Trial (LaMinute_FIP)

Fibrosing interstitial lung diseases or pulmonary fibrosis represent a heterogeneous group of progressive pulmonary pathologies, responsible for a significant morbi-mortality. They are defined by an infiltration of the pulmonary interstitium associating in a variable way an inflammatory component (deposit of inflammatory cells) and a fibrosing component (deposit of collagen). Idiopathic …

carbon monoxide
6-minute walk test
hypersensitivity pneumonitis
  • 21 Oct, 2022
  • 1 location
Comparison of Dual-Task Timed Up and Go Test (Cognitive) and 3-m Backwards Walk Test

Two balance assessment tools that have been used recently have attracted considerable attention: the Dual-Task Timed Up and Go Test (cognitive) (DTUG) and the 3-m Backward Walk Test (3MBWT). The aim of this study is to compare the psychometric properties of two clinically proven balance assessment tools.

Accepts healthy volunteers
  • 24 Mar, 2022
  • 1 location
A Six Minute Walking Test Based Index as an Outcome Predictor in COPD Subjects. (Chronic Obstructive Pulmonary Disease)

The six minute walking test (6MWT) is a recognized clinical test to evaluate exercise capacity in different diseases and different conditions. The modalities of performance are described in International Guidelines. The usually reported measure is the distance in meters walked in 6 minutes. Despite the report of a single variable …

  • 10 Feb, 2021
  • 1 location
Molecular Diagnosis of Idiopathic Interstitial Pneumonias: a Prospective Study

Molecular diagnosis of idiopathic interstitial pneumonias is an innovative way to potentially improve the diagnostic accuracy of surgical lung biopsies (SLBs), introducing molecular classifiers of idiopathic pulmonary fibrosis (IPF) vs. non-specific interstitial pneumonia (NSIP), the 2 main types of idiopathic interstitial pneumonias (IIPs). The investigators hypothesize that pre-defined gene expression …

connective tissue disease
lung biopsy
chest ct
ct scan
  • 07 Feb, 2022
  • 1 location