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Found 4 clinical trials
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease (HOPE Kids 2)

This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged 2 to < 15 years old, with Sickle Cell Disease. The primary objective

transcranial doppler ultrasonography
gbt440
voxelotor
anemia
cerebral blood flow
  • 224 views
  • 02 Mar, 2022
  • 25 locations
Voxelotor Neurocognitive Function Study

This is a Phase 3b, randomized, double-blind, placebo-controlled, multicenter study to assess the treatment effect of voxelotor on neurocognitive function as assessed by the National Institute

voxelotor
  • 0 views
  • 21 Mar, 2022
  • 1 location
A Voxelotor for Sickle Cell Anemia Patients at Highest Risk for Progression of Chronic Kidney Disease

This study is a single center, prospective exploratory pilot study of Sickle Cell Anemia (SCA) participants. The study will enroll patients with early stages of sickle cell nephropathy (Chronic Kidney Disease (CKD) stage 1 or 2) who are at the highest risk of CKD progression (presence of both hemoglobinuria and …

thalassemia
voxelotor
hydroxyurea
  • 1 views
  • 10 Jul, 2022
  • 1 location
Study to Evaluate the Effect of GBT440 in Pediatrics With Sickle Cell Disease (HOPE Kids)

, tolerability, and PK study, which includes the assessment of hematological effects and the effect on TCD flow velocity of voxelotor in pediatric participants with Sickle Cell Disease ages 4 to 17 years.

thalassemia
hydroxyurea
hemoglobin s
sickle cell trait
gbt440
  • 5 views
  • 28 Jul, 2022
  • 11 locations