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Found 14 clinical trials
Serological Screen and Treat Trial for Plasmodium Vivax (SSAT)

This is a clinical trial to evaluate an experimental serological diagnostic technique intended to identify people at high risk of having dormant malaria parasites in their liver. The study is designed to evaluate the efficacy of serological screening vs. routine care for the prevention of recurrent P. vivax infections. A …

Accepts healthy volunteers
  • 0 views
  • 27 Jul, 2022
  • 1 location
Study to Evaluate Primaquine for Radical Cure of Uncomplicated Plasmodium Vivax Malaria in Children (CHILDPRIM)

The main determinant of primaquine efficacy is the total dose of primaquine administered, rather than the dosing schedule. Infants and children younger than 4 years of age are at a higher risk of frequent relapses than older age groups, which may lead to severe anaemia. In view of this issue, …

  • 0 views
  • 25 Jul, 2022
  • 2 locations
Safety, Immunogenicity and Efficacy of the Blood-stage Plasmodium Vivax Malaria Vaccine Candidate PvDBPII in Matrix M1

This is an Open label, first-in-human, Phase I/IIa, blood-stage P. vivax malaria vaccine trial to assess the safety, immunogenicity and efficacy of the blood-stage Plasmodium vivax malaria

blood donation
chmi
Accepts healthy volunteers
antimalarials
glucose-6-phosphate dehydrogenase
  • 0 views
  • 26 Mar, 2022
  • 1 location
Rigorous Assessment of P. Vivax Relapses and Primaquine Efficacy for Radical Cure

The study will be an open-labelled randomized clinical trial to determine therapeutic efficacy. Note that this will not be an Investigational New Drug application, as only World Health Organization (WHO)-approved drugs will be used at dosage and for conditions approved.

  • 0 views
  • 27 May, 2022
  • 1 location
Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine (EFFORT)

Health care facility based, randomized, controlled, open label, superiority trial with 3 arms

  • 0 views
  • 24 May, 2022
  • 4 locations
Vivax Malaria Human Infection Studies in Thailand (MIST1)

. vivax-infected blood for use in future controlled human P. vivax malaria infection studies. Additional objectives are to obtain data on host immune response to P. vivax infection and pre-treatment

Accepts healthy volunteers
  • 0 views
  • 15 Jun, 2022
  • 1 location
Short Course Radical Cure of P. Vivax Malaria in Nepal

This study is designed as a multicentre randomized, open label trial to assess the safety and efficacy of a low dose short course PQ treatment (3.5mg/kg total dose given over 7 days) in glucose-6-phosphate dehydrogenase (G6PD) normal patients with P.vivax and P falciparum to reduce the risk of subsequent P.vivax …

  • 0 views
  • 11 May, 2022
  • 2 locations
Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients

A clinical study to assess the safety and efficacy of alternative regimens of primaquine for radical cure of vivax malaria in glucose 6-phosphate dehydrogenase (G6PD) deficient. G6PD deficient

g6pd deficiency
primaquine
hemolysis
glucose-6-phosphate dehydrogenase
chloroquine
  • 37 views
  • 12 Apr, 2022
  • 2 locations
Efficacy of SJ733 in Adults With Uncomplicated Plasmodium Falciparum or Vivax Malaria

This Phase 2a trial recruits adult patients with uncomplicated P. vivax or P. falciparum blood-stage malaria mono-infection. The study drug SJ733 will be administered to examine its antimalarial efficacy, safety, and tolerability. This study also evaluates whether or not a fixed dose of the pharmacoenhancer cobicistat when given in combination …

  • 0 views
  • 30 May, 2022
  • 1 location
A Controlled Human Vivax Malaria Infection Study Through Inoculation of Infected Erythrocytes (MIST2)

The primary objectives of this study are to assess the safety and feasibility of blood-stage controlled human P. vivax malaria infection (CHMI) in healthy adult Thai volunteers through

Accepts healthy volunteers
  • 0 views
  • 14 Jul, 2022
  • 1 location