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Found 56 clinical trials
Soluble Cluster of Differentiation 160 (sCD160) in Sera and Intra-ocular Fluids: Association With Ischaemic Retinopathies

CD160 represents a new angiogenic factor as its specific engagement by an agonist monoclonal antibody directed against human CD160 reduced angiogenesis of endothelial cells with a distinct mechanism from current angiogenic therapies that target the VEGF/VEGF-R pathway. A soluble form of CD160, sCD160, has been found to be highly expressed …

retinal disease
retinopathy
corticosteroids
growth factor
angiography
  • 6 views
  • 24 Jan, 2021
  • 1 location
Combined Antioxidant Therapy on Oxidative Stress Mitochondrial Dysfunction Markers in Diabetic Retinopathy

The present study aims to support previous research on antioxidant therapy effects in diabetic retinopathy outcome. The investigators intend to assess 180 patients with diabetic retinopathy in different stages (moderate, severe and proliferative), whom either will be assigned to placebo group or combined antioxidant therapy. Each group will receive the …

hemoglobin a1c
glycosylated hemoglobin
retinopathy
type 2 diabetes mellitus
edema
  • 16 views
  • 24 Jan, 2021
  • 1 location
Evaluating Medium-chain Triglycerides as a Temporary Intraocular Tamponading Agent for Retinal Detachment

Background : Surgery is needed in order to flatten and position a detached retina onto the choroid, to allow sealing of the tears and to prevent or reverse vision loss. In case of complex retinal detachment vitrectomies followed by ocular endotamponade - non-solid implants used in ophthalmology - is the …

retinal detachment
retinopathy
blindness
diabetic retinopathy
detachment
  • 2 views
  • 26 Jan, 2021
  • 1 location
Intravitreal Avastin Versus Intravitreal Avastin and Triamcinolone in Central Retinal Vein Occlusion(CRVO)

In this study we intend to evaluate and compare the outcomes of intravitreal avastin versus avastin and triamcinolone on improving the visual acuity and macular edema and late complications of CRVO like NVI and NVG.

  • 1 views
  • 07 Nov, 2020
  • 1 location
Intravitreal Aflibercept for the Prevention of Proliferative Vitreoretinopathy Following Retinal Detachment Repair

The primary objective of the study is to determine if serial intravitreal aflibercept injections (IAI) improve the single surgery anatomic success rate following surgical repair of primary, macula involving rhegmatogenous retinal detachment (RRD) deemed at high risk for proliferative vitreoretinopathy (PVR). Preclinical work has revealed that competitive inhibition of platelet …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Efficacy and Safety Study of Intravitreal Triamcinolone to Treat Diffuse Diabetic Macular Edema

The purpose of this study is to determine whether intravitreal injection of Triamcinolone Acetonide is effective in the treatment of Clinically Significant Diffuse Macular Edema due to Type 2 Diabetes Mellitus.

injection of triamcinolone
optical coherence tomography
retinopathy
type 2 diabetes mellitus
diabetes
  • 194 views
  • 07 Nov, 2020
  • 1 location
INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study

The central hypothesis is that inflammation mediators are biomarkers of both systemic diabetes and Diabetic Retinopathy (DR) progression in the aqueous and that sustained topical ketorolac application reduces/suppresses those inflammatory mediators thereby reducing the progression of Diabetic Retinopathy.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Retinal Detachment - Demographic and Clinical Survey

> Two different general surgical treatment options exist for retinal detachment; scleral buckling or vitrectomy. However, the precise indications for each approach have not been well established

  • 4 views
  • 24 Mar, 2021
  • 1 location
Visual Acuity and Optical Coherence Tomography One Year After ILM-flap Transposition

ILM-flap (internal limiting Membrane-flap) transposition is a new surgical option in repair of macular holes, therefore one year outcomes are needed to better evaluate that method.

optical coherence tomography
  • 3 views
  • 31 Jan, 2021
  • 1 location
Retinal Displacement After Pneumatic Versus Vitrectomy for Retinal Detachment (ALIGN)

Vitrectomy (PPV) and Pneumatic Retinopexy (PnR).

vitrectomy
retinopexy
rhegmatogenous retinal detachment
repair of retinal detachment
  • 20 views
  • 05 May, 2021
  • 1 location