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Found 43 clinical trials
A Pilot Study in Severe Patients With Takayasu Arteritis.

Takayasu arteritis (TAK) is a rare chronic inflammatory arteritis, which lacks an effective well-accepted intervention strategy. We classify TAK patients into 3 levels, including mild, moderate, and severe. And the biological agents tocilizumab and adalimumab are randomly prescribed in severe patients, to find out the relatively better treatment strategy, facilitating …

tocilizumab
adalimumab
  • 0 views
  • 26 Jan, 2021
  • 1 location
Intravitreal Adalimumab in Refractory Diabetic Retinopathy Choroidal Neovascularization or Uveitis: A Pilot Study

Direct intravitreal administration of medication is the preferred method of treatment for uveitis and retinal vascular disorders. The eye is a self contained organ relatively isolated from the systemic circulation by the tight blood retinal barrier. Effective intraocular drug levels can be achieved with a much smaller amount of medication …

diabetic retinopathy
uveitis
retinal vascular
neovascularization
retinopathy
  • 78 views
  • 07 Nov, 2020
  • 1 location
The K-Map Study Global Prevalence of KC

severe visual loss. The overall goal of this study is to assess the prevalence of keratoconus (KC) in children and adolescents in various regions of the world based on modern tomographic imaging

  • 8 views
  • 05 May, 2021
  • 3 locations
Uveitis/Intraocular Inflammatory Disease Biobank (iBank)

Background Uveitis is a serious eye disease that can cause vision loss. Treatment sometimes causes serious side effects or does not work. Researchers want to learn more about uveitis and why some people develop it. Objective To learn clinical and genetic factors that may make people develop uveitis and influence …

inflammatory disorder
behcet's syndrome
eye inflammation
eye drops
sarcoidosis
  • 25 views
  • 27 Jan, 2021
  • 1 location
Natural History Study of Patients With Leber Congenital Amaurosis Associated With Mutations in RPE65

MGT005 is a natural history study to collect longitudinal prospective data from patients with Leber Congenital Amaurosis associated with defects in RPE65.

  • 0 views
  • 20 Mar, 2021
  • 2 locations
Initial Clinical Presentation of Inflammatory Optic Neuritis Associated or Not With Autoantibodies Anti-Myelin-oligodendrocyte-glycoprotein

In eight ophthalmic units, the investigator will include all inflammatory optic neuritis (ON) during acute phase and rank them in two groups: 1/ ON with autoantibodies anti-myelin-oligodendrocyte-glycoprotein (ON MOG+) 2/ ON MOG-. The investigators will measure incidence of MOG-Ab in our prospective population of inflammatory ON. Then the investigator will …

  • 0 views
  • 26 Jan, 2021
  • 8 locations
" Sweeper " and Epiretinal Membrane Surgery

Epiretinal membrane (ERM) is a pathological phenomenon requiring surgery when vision is altered. ERM surgery requires ERM peeling, then active internal limiting membrane (ILM) peeling if it is not spontaneously peeled with ERM. Initiation of peeling is very delicate and can lead to micro scotoma when realized with microscopic forceps. …

optical coherence tomography
  • 0 views
  • 25 Jan, 2021
  • 1 location
Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)

A multi-centre observational study recruiting prospective and retrospective cohorts of patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The primary aim is to find genetic determinants of GCA and PMR susceptibility, in order to yield novel insights into disease pathogenesis. A subset of the retrospective cohort is also …

  • 0 views
  • 23 Jan, 2021
  • 52 locations
Natural History of Neuronal Ceroid Lipofuscinosis Batten's CLN6 Diseae

CLN6 is a rare, neurodegenerative disease that causes progressive loss of acquired skills with motor delay, visual loss, seizures and ataxia. The investigators propose a natural history study of

neurodegenerative disorders
seizure
cln6
ataxia
batten
  • 57 views
  • 29 Jan, 2021
  • 1 location
Non-invasive Optical Angiography in Age-related Macular Degeneration

Age-related macular degeneration (AMD) is the leading cause of severe and irreversible visual loss and classified blindness in the elderly throughout Europe and the US. Among these patients

age-related macular degeneration
blindness
angiography
vegf
fluorescein angiography
  • 17 views
  • 26 Mar, 2021
  • 1 location