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Found 43 clinical trials
Safety and Efficacy Study in Patients With Retinitis Pigmentosa Due to Mutations in PDE6B Gene

The study is a Phase I/II, monocentric, open-label, dose-ranging safety and efficacy gene therapy intervention by subretinal administration of AAV2/5-hPDE6B. At least twelve patients 18 years of age or older, within four consecutive cohorts of patients, will be recruited.

gene therapy
  • 1146 views
  • 27 Mar, 2021
  • 1 location
Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)

The main purpose of this study is to assess clemastine as a remyelinating agent in patients with acute optic neuritis.The study will also evaluate the tolerability of clemastine, originally approved as first-generation antihistamine, in patients with optic neuritis. Study procedures will include assessments for evidence of remyelination in the anterior …

antihistamine
  • 27 views
  • 11 Apr, 2021
  • 1 location
A Comparison of Standard Laser With Micropulse Laser for the Treatment of Diabetic Macular Oedema.

DIAMONDS is a Randomised Controlled Clinical Trial that is being carried out in the UK to determine the clinical effectiveness and cost-effectiveness of micropulse laser, compared with standard laser, for the treatment of diabetic macular oedema.

diabetic retinopathy
retinopathy
optical coherence tomography
spectral domain optical coherence tomography
  • 66 views
  • 22 Jan, 2021
  • 12 locations
Investigation of Potential Retinal Toxicity Associated With Hair Dye Products Containing pPD Type Aromatic Amines

are likely to be underdiagnosed, since the associated visual loss is usually mild and so this condition should be considered when patients report blurred vision. The aim of the study is to analyze

  • 0 views
  • 01 Feb, 2021
  • 1 location
Pars-plana Vitrectomy vs Panretinal Photocoagulation for Severe NPDR

development PDR within 1 year follow up, 45% will develop high-risk PDR, nearly half of PDR will experience profound visual loss. panretinal photocoagulation (PRP) only reduced 50% risk of sever visual loss

  • 0 views
  • 01 May, 2021
  • 1 location
Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis

without known reasons, causing severe irreversible visual loss. The overall recurrence rate of OT in Europe is greater than 80% for patients and may range from one episode to 11 episodes (1% of OT) in the

  • 4 views
  • 25 Jan, 2021
  • 1 location
Optic Neuritis Differential Diagnosis Study

used in NMO are different from those used in MS, which can worsen the natural history of NMO. Early differential diagnosis of these diseases is thus crucial for preventing severe visual loss and

vision loss
nervous
bilateral optic neuritis
neuritis
severe visual loss
  • 3 views
  • 23 Jan, 2021
  • 1 location
Macular Perfusion Changes After Anti-VEGF Versus Targeted Retinal Photocoagulation in Proliferative Diabetic Retinopathy

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM), while proliferative diabetic retinopathy (PDR) is the principal cause of severe visual loss in

  • 0 views
  • 10 Apr, 2021
  • 1 location
MEthotrexate Versus TOcilizumab for Treatment of GIant Cell Arteritis: a Multicenter Randomized Controlled Trial

extra-cranial branches of the external carotid, with vascular remodelling leading to ischemic manifestations such as temporal headaches, jaw claudication, scalp tenderness and visual loss. Most patients

vasculitis
positron emission tomography
blindness
tenderness
remission
  • 3 views
  • 05 May, 2021
  • 1 location
ACT-01 in Patients With Acute Optic Neuritis

To evaluate the safety and tolerability of ACT-01 compared to placebo in patients with acute optic neuritis (AON) receiving the standard of care.

  • 0 views
  • 14 Mar, 2021
  • 2 locations