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Found 37 clinical trials
Piclidenoson for Treatment of COVID-19

Patients with documented moderate COVID-19 infection will be randomized 1:1 to receive piclidenoson 2 mg Q12H orally with standard supportive care (SSC - intervention arm) or placebo orally with SSC (control arm) for up to 28 days.

  • 0 views
  • 04 Feb, 2021
  • 2 locations
Modified Virus VSV-IFNbetaTYRP1 in Treating Patients With Stage III-IV Melanoma

This phase I trial studies the side effects and best dose of a modified virus called VSV-IFNbetaTYRP1 in treating patients with stage III-IV melanoma. The vesicular stomatitis virus (VSV) has been altered to include two extra genes: human interferon beta (hIFNbeta), which may protect normal healthy cells from becoming infected …

  • 12 views
  • 26 Jan, 2021
  • 3 locations
CRISIS2: A Phase 2 Study of the Safety and Antiviral Activity of Brequinar in Non-hospitalized Pts With COVID-19

This study will assess the efficacy and safety of DHODHi (brequinar) as an antiviral via 5 days of treatment of participants with positive COVID-19 and at least one symptom of COVI019 in an out-patient setting. The study is multi-center, randomized, and placebo-controlled.

  • 0 views
  • 02 Feb, 2021
  • 16 locations
MV-NIS or Investigator's Choice Chemotherapy in Treating Patients With Ovarian Fallopian or Peritoneal Cancer

This randomized phase II trial studies how well oncolytic measles virus encoding thyroidal sodium iodide symporter (MV-NIS) compared to investigator's choice chemotherapy works in treating patients with ovarian, fallopian, or peritoneal cancer. Measles virus, which has been changed in a certain way, may be able to kill tumor cells without …

carboplatin
cytotoxic chemotherapy
cancer antigen 125
ct scan
oophorectomy
  • 41 views
  • 26 Jan, 2021
  • 3 locations
VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Patients With Relapsed or Refractory Multiple Myeloma Acute Myeloid Leukemia or T-cell Lymphoma

This phase I trial studies the best dose and side effects of recombinant vesicular stomatitis virus carrying the human NIS and IFN beta genes (VSV-hIFNbeta-sodium iodide symporter [NIS]) with or without ruxolitinib phosphate in treating patients with multiple myeloma, acute myeloid leukemia, or T-cell lymphoma that has come back or …

lymphoma
stem cell transplantation
direct bilirubin
ct scan
refractory multiple myeloma
  • 40 views
  • 27 Jan, 2021
  • 2 locations
VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Patients With Stage IV or Recurrent Endometrial Cancer

This phase I trial studies the side effects and best dose of vesicular stomatitis virus-human interferon beta-sodium iodide symporter (VSV-hIFNbeta-NIS) with or without ruxolitinib phosphate in treating patients with stage IV endometrial cancer or endometrial cancer that has come back. The study virus, VSV-hIFNbeta-NIS, has been changed so that it …

ct scan
primary tumor
warfarin
chemotherapy regimen
sodium-iodide symporter
  • 15 views
  • 27 Jan, 2021
  • 2 locations
Hypertonic Saline for COVID-19 Symptoms

Rationale Coronavirus disease 2019 (COVID-19) is spreading rapidly in the world with no proven effective therapy to date. Some patients with COVID-19 develop sever respiratory disease requiring ICU care. There is in vitro evidence that hypertonic saline (HTS) may be beneficial in reducing the inflammatory component in similar viral illnesses. …

cough
respiratory symptom
oximetry
covid-19
dyspnea
  • 112 views
  • 25 Jan, 2021
  • 1 location
Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 1 Infection

This is a phase II, double-blind, randomised, controlled, multicentre trial of topical HDIT101 versus placebo. HSV-1-positive patients with at least 6 orolabial herpes lesions in the last 12 months can be included. The patients need to present with 3 herpes lesions within a 9 months observation phase. With the occurrence …

immunoglobulin
herpes infection
  • 30 views
  • 27 Jan, 2021
  • 5 locations
Viral Shedding Symptoms and Exposure of SARS-CoV-2 in Non-hospitalized Children With COVID-19

Data on COVID-19 in children are still scarce, and their role in SARS-CoV-2 transmission is poorly described. Furthermore, documentation of the best SARS-CoV-2 sampling methods in children are limited. In adults, saliva seems like a promising specimen to collect by noninvasive procedure to diagnose and monitor viral load of SARS-CoV-2, …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Evaluating the Immune Response for COVID-19

impede infection control. The other question to consider is whether these asymptomatic carriers develop an immune response or continue viral shedding. The purpose of the current study is the evaluate the

SARS
covid-19
coronavirus infection
viral shedding
  • 0 views
  • 22 Feb, 2021
  • 1 location