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Found 15 clinical trials
OH2 Oncolytic Viral Therapy in Advanced Bladder Cancer

This Ⅱ study evaluates the safety and efficacy of intratumoral injection of OH2 in locally advanced or metastatic bladder cancer. OH2 is an oncolytic virus developed upon genetic modifications of the herpes simplex virus type 2 strain HG52, allowing the virus to selectively replicate in tumors. Meanwhile, the delivery of …

  • 0 views
  • 04 Oct, 2022
  • 1 location
OH2 Oncolytic Viral Therapy in Non-Muscle-Invasive Bladder Cancer

This phase Ⅰb/Ⅱ study evaluates the safety and efficacy of OH2 for adjuvant therapy in non-muscle-invasive bladder cancer after first-line prophylactic intravesical instillation therapy. OH2 is an oncolytic virus developed upon genetic modifications of the herpes simplex virus type 2 strain HG52, allowing the virus to selectively replicate in tumors. …

  • 0 views
  • 04 Oct, 2022
  • 1 location
OH2 Oncolytic Viral Therapy in Pancreatic Cancer

This phase Ib/II study evaluates the safety and efficacy of OH2 in patients with locally advanced/metastatic pancreatic cancer who have failed first-line standard treatment. OH2 is an oncolytic virus developed upon genetic modifications of the herpes simplex virus type 2 strain HG52, allowing the virus to selectively replicate in tumors. …

liver metastasis
cancer chemotherapy
paclitaxel
metastatic pancreatic cancer
measurable disease
  • 0 views
  • 25 Mar, 2022
  • 1 location
OH2 Oncolytic Viral Therapy in Solid Tumors

This phase I/II study evaluates the safety and efficacy of OH2 as single agent or in combination with HX008, an anti-PD-1 antibody, in patients with malignant solid tumors (gastrointestinal cancers, head and neck cancers, soft tissue sarcomas). OH2 is an oncolytic virus developed upon genetic modifications of the herpes simplex …

measurable disease
sarcoma
colony stimulating factor
immunoglobulin
cancer
  • 51 views
  • 11 Jul, 2022
  • 1 location
OH2 Oncolytic Viral Therapy in Central Nervous System Tumors

In the first phase, it mainly explores the safety, tolerability and preliminary effectiveness of two doses of OH2 injection in the treatment of patients with recurrent central nervous system tumors; to evaluate the biodistribution and virus shedding of OH2 injection administered in the tumor cavity; to evaluate the level of …

  • 0 views
  • 22 Mar, 2022
  • 1 location
Open Multi-cohort Study of the First Phase of Safety of a Drug Based on Double Recombinant Vaccinia Virus VV-GMCSF-Lact

Purpose of the study is to evaluate the safety, tolerability and pharmacokinetic parameters of the drug based on double recombinant vaccinia virus VV-GMCSF-Lact, in patients with recurrent/refractory metastatic breast cancer in successive cohorts with dose escalation with single and multiple administration. The study provides: determination of the maximum tolerated dose …

  • 0 views
  • 26 May, 2022
  • 1 location
Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery

This phase I trial studies the side effects of OBP-301 when given together with carboplatin, paclitaxel, and radiation therapy in treating patients with esophageal or gastroesophageal cancer that invades local or regional structures. OBP-301 is a virus that has been designed to infect and destroy tumor cells (although there is …

chemotherapy drugs
esophageal cancer
paclitaxel
squamous cell carcinoma
neutrophil count
  • 0 views
  • 04 Oct, 2022
  • 6 locations
Stop Hep B @ Birth

, vaccination, and anti-viral therapy for HBV among household members of women with chronic HBV infection.

cirrhosis
tenofovir
hepatitis b immune globulin
encephalopathy
hepatitis
  • 0 views
  • 15 Aug, 2021
  • 1 location
Carvedilol for Prevention of Esophageal Varices Progression (Carvedilol)

Carvedilol has been shown to be more potent in decreasing portal hypertension to propranolol. But the efficacy of carvedilol to delay the growth of esophageal varices in chronic hepatitis B patients was unclear.

propranolol
hypertension
antiviral drugs
varicose veins
esophageal varices
  • 4 views
  • 24 Mar, 2022
  • 6 locations
Extension Study of Carvedilol RCT Study

Patients who have completed 2-years treatment in RCT Study of carvedilol will receive another 2-years extension therapy, aiming to investigate the long-term efficacy of carvedilol for the prevention of esophageal varices in treated HBV cirrhotic patients.

esophageal varices
carvedilol
  • 0 views
  • 01 Sep, 2021
  • 14 locations