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Found 10 clinical trials
Arbidol for COPD Exacerbations

COPD. Since respiratory viral infections are the mainly trigger of AECOPD, anti-viral therapy would be the affective method to prevent the exacerbation or reduce the attack severity. However, there are

  • 0 views
  • 23 Jan, 2021
  • 1 location
OH2 Oncolytic Viral Therapy in Pancreatic Cancer

This phase Ib/II study evaluates the safety and efficacy of OH2 in patients with locally advanced/metastatic pancreatic cancer who have failed first-line standard treatment. OH2 is an oncolytic virus developed upon genetic modifications of the herpes simplex virus type 2 strain HG52, allowing the virus to selectively replicate in tumors. …

paclitaxel
measurable disease
metastasis
gemcitabine
liver metastasis
  • 0 views
  • 25 Mar, 2022
  • 1 location
OH2 Oncolytic Viral Therapy in Central Nervous System Tumors

In the first phase, it mainly explores the safety, tolerability and preliminary effectiveness of two doses of OH2 injection in the treatment of patients with recurrent central nervous system tumors; to evaluate the biodistribution and virus shedding of OH2 injection administered in the tumor cavity; to evaluate the level of …

  • 0 views
  • 22 Mar, 2022
  • 1 location
Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery

This phase I trial studies the side effects of OBP-301 when given together with carboplatin, paclitaxel, and radiation therapy in treating patients with esophageal or gastroesophageal cancer that invades local or regional structures. OBP-301 is a virus that has been designed to infect and destroy tumor cells (although there is …

esophageal cancer
cancer
paclitaxel
chemotherapy regimen
ct scan
  • 0 views
  • 24 Apr, 2022
  • 6 locations
Stop Hep B @ Birth

, vaccination, and anti-viral therapy for HBV among household members of women with chronic HBV infection.

encephalopathy
cirrhosis
fumarate
vaccination
tenofovir
  • 0 views
  • 15 Aug, 2021
  • 1 location
Carvedilol for Prevention of Esophageal Varices Progression (Carvedilol)

Carvedilol has been shown to be more potent in decreasing portal hypertension to propranolol. But the efficacy of carvedilol to delay the growth of esophageal varices in chronic hepatitis B patients was unclear.

antiviral drugs
esophageal varices
varicose veins
hypertension
propranolol
  • 4 views
  • 24 Mar, 2022
  • 6 locations
Extension Study of Carvedilol RCT Study

Patients who have completed 2-years treatment in RCT Study of carvedilol will receive another 2-years extension therapy, aiming to investigate the long-term efficacy of carvedilol for the prevention of esophageal varices in treated HBV cirrhotic patients.

esophageal varices
carvedilol
  • 0 views
  • 01 Sep, 2021
  • 14 locations
T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias

The purpose of this study is to evaluate what effect, if any, mismatched unrelated volunteer donor and/or haploidentical related donor stem cell transplant may have on severe sickle cell disease and other transfusion dependent anemias. By using mismatched unrelated volunteer donor and/or haploidentical related donor stem cells, this study will …

alemtuzumab
blood transfusion
hepatopathy
shortening fraction
sickle cell anemia
  • 46 views
  • 15 May, 2022
  • 1 location
Long-term Outcomes of Anti-viral Therapies in Patients With Chronic Viral Hepatitis B

This is a multicenter, prospective, real-world study, recruiting patients with chronic hepatitis B under anti-viral treatment. The recruited participants will receive peginterferon alpha based regimen or nucleos(t)ide alone. The primary objective of this study is to compare the long-term outcomes (including hepatocellular carcinoma, decompensated cirrhosis, etcof different anti-viral therapies. The …

entecavir
hepatocellular carcinoma
cirrhosis
tenofovir
hepatitis
  • 0 views
  • 30 May, 2021
  • 1 location
PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort

DESIGN Longitudinal prospective observational multicentre study. Primary objective: Understand the immune mechanisms driving COVID-19 disease in patients with a history of lung disease

blood test
covid-19
pulmonary disease
asthma
COPD
  • 35 views
  • 31 Aug, 2021
  • 1 location