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Found 139 clinical trials
A Phase 3 Randomized Study of Selumetinib Versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)

This phase III trial studies if selumetinib works just as well as the standard treatment with carboplatin/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if

subependymal giant cell astrocytoma
gilbert disease
giant cell astrocytoma
carboplatin
selumetinib
  • 277 views
  • 18 Sep, 2022
  • 59 locations
Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies (NYMC195)

Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective

metastasis
vorinostat
granulocyte colony stimulating factor
platelet transfusion
glomerular filtration rate
  • 3 views
  • 01 Mar, 2022
  • 1 location
Chemotherapy Induced Peripheral Neuropathy (CIPN) and Lymphoma Longitudinal Follow-up and Prognostic Factors (NeuroTox-L)

Vincristine-induced peripheral neuropathy, which is commonly a sensorimotor neuropathy, remains a major complication of lymphoma patients treated with R-CHOP. The investigators propose a

vincristine
chemotherapy regimen
lymphoma
chop regimen
  • 0 views
  • 27 May, 2022
  • 1 location
N9: Pilot Study of Novel Shortened Induction Chemotherapy for High-Risk Neuroblastoma

different times - Cyclophosphamide, topotecan, and vincristine (CTV), Ifosfamide, carboplatin, and etoposide (ICE), Cyclophosphamide, doxorubicin, and vincristine (CDV).

cyclophosphamide
renal function
carboplatin
etoposide
topotecan
  • 0 views
  • 20 Aug, 2022
  • 1 location
A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine Versus Selumetinib (NSC# 748727) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) Not Associated With BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)

This phase 3 trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously

residual tumor
low grade glioma
giant cell astrocytoma
carboplatin
selumetinib
  • 14 views
  • 18 Sep, 2022
  • 65 locations
Phase I and Dose-Expansion Study of Ibrutinib and R-da-EPOCH for Front Line Treatment of AIDS-Related Lymphomas

This phase I trial studies the side effect and best dose of ibrutinib in combination with rituximab, etoposide, prednisone, vincristine sulfate, cyclophosphamide, and doxorubicin hydrochloride

  • 130 views
  • 16 Sep, 2022
  • 16 locations
A Phase II Study of Venetoclax in Combination With Dose-adjusted EPOCH-R or R-CHOP for Patients With Richter's Syndrome

drugs involved in this study are: Venetoclax R-EPOCH: Rituximab Etoposide Prednisone Vincristine Sulfate (Oncovin)

  • 16 views
  • 25 Jul, 2022
  • 2 locations
A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma

This phase III trial compares the safety and effect of adding vinorelbine to vincristine, dactinomycin, and cyclophosphamide (VAC) for the treatment of patients with high risk rhabdomyosarcoma

vinorelbine
cancer
vincristine
cancer chemotherapy
glomerular filtration rate
  • 0 views
  • 09 Aug, 2022
  • 1 location
A TACL Phase 1/2 Study of PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma IND# 140730

This is a phase 1/2 study of a drug called Ixazomib in combination with cytotoxic chemotherapy consisting of Vincristine, Dexamethasone, Asparaginase, and Doxorubicin (VXLD).

methotrexate
mercaptopurine
lymphoma
inotuzumab
graft versus host disease
  • 3 views
  • 20 Aug, 2022
  • 17 locations
A Randomized Phase II Study of CHO(E)P vs CC-486-CHO(E)P vs Duvelisib-CHO(E)P in Previously Untreated CD30 Negative Peripheral T-Cell Lymphomas

This phase II trial studies the effect of duvelisib or CC-486 and usual chemotherapy consisting of cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone in treating patients with

angioimmunoblastic t-cell lymphoma
prednisone
corticosteroids
peripheral t-cell lymphoma
experimental drug
  • 0 views
  • 19 Aug, 2022
  • 20 locations