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Found 151 clinical trials
Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

This randomized phase III trial studies how well combination chemotherapy (vincristine sulfate, dactinomycin, cyclophosphamide alternated with vincristine sulfate and irinotecan hydrochloride or

neutrophil count
vincristine
cancer
cancer chemotherapy
platelet count
  • 292 views
  • 03 Mar, 2021
  • 284 locations
Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

. The purpose of Phase 2 of this study is to compare the rate of complete response (CR) of carfilzomib in combination with vincristine, dexamethasone, PEG asparaginase, daunorubicin (VXLD

  • 125 views
  • 18 Feb, 2021
  • 79 locations
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

or hepatocellular carcinoma. Drugs used in chemotherapy, such as cisplatin, doxorubicin, fluorouracil, vincristine sulfate, carboplatin, etoposide, irinotecan, sorafenib, gemcitabine and oxaliplatin

oxaliplatin
vincristine
fluorouracil
cancer
carboplatin
  • 178 views
  • 14 Feb, 2021
  • 134 locations
A Randomized Multicenter Phase III Trial Comparing Treatment With R-mini-CHOP With R-mini-CHP + Polatuzumab Vedotin in Patients With Diffuse Large Cell B Cell Lymphoma

for this population, R-miniCHOP, or an experimental regimen, R-pola-miniCHP, where vincristine is substituted by an immunoconjugate, polatuzumab vedotin. The duration of the screening period is up to

vincristine
high grade b-cell lymphoma
indolent lymphoma
b-cell lymphoma
follicular lymphoma
  • 0 views
  • 27 Jan, 2021
  • 47 locations
Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

radiation from x-rays to kill cancer cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, vincristine sulfate, cyclophosphamide and lomustine, work in different ways to stop the growth of

medulloblastoma
neutrophil count
platelet count
MRI
brain tumor
  • 119 views
  • 13 Feb, 2021
  • 133 locations
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

. Drugs used in chemotherapy, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexate, cytarabine, mercaptopurine, doxorubicin, cyclophosphamide, and thioguanine, work in

dexamethasone
mercaptopurine
combination chemotherapy
lymphoblastic lymphoma
pegaspargase
  • 84 views
  • 03 Mar, 2021
  • 118 locations
Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

incidence and/or severity of acute vincristine-induced peripheral neuropathy can be reduced by decreasing the dosage of vincristine in patients with the high-risk CEP72 TT genotype or by shortening the

dexamethasone
dasatinib
lymphoblastic lymphoma
clofarabine
pegaspargase
  • 230 views
  • 29 Jan, 2021
  • 7 locations
High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)

of induction should receive 2 TVD (Topotecan, Vincristine, Doxorubicin) cycles. After Rapid COJEC induction, localized patients will proceed to consolidation. Patients aged 12-18 months at

isotretinoin
busulfan
colony stimulating factor
filgrastim
carboplatin
  • 288 views
  • 26 Jan, 2021
  • 126 locations
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL Mixed Phenotype Acute Leukemia and B-LLy

, vincristine, and pegaspargase work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial will also

dexamethasone
daunorubicin
inotuzumab
mercaptopurine
testicular
  • 42 views
  • 31 Jan, 2021
  • 112 locations
International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

The study PNET 5 MB has been designed for children with medulloblastoma of standard risk (according to the risk-group definitions which have been used so far; e.g. in PNET 4). With the advent of biological parameters for stratification into clinical medulloblastoma trials, the -catenin status will be the only criterion …

medulloblastoma
residual tumor
metastasis
nervous
  • 90 views
  • 21 Jan, 2021
  • 57 locations