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Found 151 clinical trials
A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG)

This is a pilot, randomized, two arm neoadjuvant vaccine study in human leukocyte antigen-A2 positive (HLA-A2+) adults with World Health Organization (WHO) grade II glioma, for which surgical resection of the tumor is clinically indicated. Co-primary objectives are to determine: 1) the safety of the novel combination of subcutaneously administered …

oligodendroglioma
absolute lymphocyte count
hiltonol
oligoastrocytoma
flair
  • 25 views
  • 25 Jan, 2021
  • 1 location
Biomarkers in Chemotherapy-Induced Peripheral Neurotoxicity

This pilot study will attempt to establish the feasibility of using tissue oxygen measurements and the protein, neurofilament light chain (NF-L), as potential biomarkers for chemotherapy-induced peripheral neuropathy (CIPN). Thirty (30) subjects scheduled to begin taxane-based chemotherapy for breast tumor will be assigned to receive an India ink injection under …

peripheral neurotoxicity
nf-l
nerve conduction studies
peripheral neuropathy
taxane
  • 18 views
  • 24 Jan, 2021
  • 1 location
Blinatumomab Followed by High-dose Chemotherapy for Ph-negative Acute Lymphoblastic Leukemia (ALL)

This is a phase II interventional trial to evaluate the efficacy of blinatumomab followed by high-dose chemotherapy in the first-line treatment for Ph-negative acute lymphoblastic leukemia (ALL) in adults. The aim is to increase the number of complete molecular responses after first two cycles of therapy. Early molecular response is …

  • 0 views
  • 25 Jan, 2021
  • 1 location
Lenalidomide Combined With Modified DA-EPOCH and Rituximab (EPOCH-R2) in Primary Effusion Lymphoma or KSHV-associated Large Cell Lymphoma

Background Primary effusion lymphoma (PEL) is a rare disease with no standard treatment. Researchers want to see if a drug called lenalidomide along with common chemotherapy drugs may be effective in treating PEL. Objective To test a new treatment for PEL. Eligibility People ages 18 and older with PEL. Design …

cyclophosphamide
chemotherapy drugs
doxorubicin
cancer chemotherapy
prednisone
  • 9 views
  • 28 Jan, 2021
  • 1 location
Early Detection of Neuropathy and Cognitive Impairment Following Treatment for Haematological Malignancies

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, but not well understood complication to treatment with chemotherapy. In this study the investigators will investigate a novel method for early detection of CIPN and compare it to other methods in patients treated for haematological cancers.

vincristine
bortezomib
peripheral neuropathy
lenalidomide
cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location
Diagnostic of Chemotherapy Induced Neuropathy in Children

The purpose of this study is to determine the diagnostic accuracy of a newly developed tool (Electrochemical Skin Conductances (ESC) measurement) easy-to-perform, non-invasive, highly reproductible and not requiring specific training, to identify pediatric chemotherapy-induced-peripheral-neuropathies (CIPN). CIPN are a frequent (20 to 75% depending on the drug), early and potentially severe …

vincristine
carboplatin
alkaloids
bortezomib
taxane
  • 0 views
  • 26 Jan, 2021
  • 1 location
A Prospective Study of Low-dose Decitabine Combined With COP Regimen in the Treatment of Relapsed and Refractory DLBCL

first-line chemotherapy regimen using Rituximab+Cyclophosphamide+Doxorubicin +Vincristine+BonisoneR-CHOPsignificantly increases the remission rate and disease-free survival of patients with DLBCL, but

  • 0 views
  • 22 Jan, 2021
  • 1 location
Tyrosine Kinase Inhibitors and Low Intensity Chemotherapy in Ph+ ALL

chemotherapy alone. The combination of imatinib, vincristine and dexamethasone is a well tolerated regimen in aged patients and is also associated with a high CR rate of 80% to 90% in patient aged 55 years and

tyrosine
dexamethasone
philadelphia chromosome
imatinib
remission
  • 8 views
  • 22 Jan, 2021
  • 3 locations
International PPB/DICER1 Registry

Pleuropulmonary blastoma (PPB) is a rare malignant neoplasm of the lung presenting in early childhood. Type I PPB is a purely cystic lesion, Type II is a partially cystic, partially solid tumor, Type III is a completely solid tumor. Treatment of children with PPB is at the discretion of the …

sarcoma
solid tumor
initial diagnosis
cancer
  • 37 views
  • 23 Jan, 2021
  • 1 location
Long Term Implications of Rare Brain Tumours'

Patients diagnosed with oligodendroglioma with a specific molecular profile represent rare tumour groups (about 10% of adult gliomas) with relatively favourable prognosis (median survival between 8 and 12 years). These patients are often treated with surgery, chemotherapy and/or radiotherapy. However, as patients live for a long period of time, they …

  • 0 views
  • 03 Feb, 2021
  • 2 locations