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Found 151 clinical trials
Carfilzomib Rituximab and Combination Chemotherapy in Treating Patients With Diffuse Large B-Cell Lymphoma

This phase I/II trial studies the side effects and best dose of carfilzomib when given together with rituximab and combination chemotherapy and to see how well they work in treating patients with diffuse large B-cell lymphoma. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes …

b-cell lymphoma
ejection fraction
combination chemotherapy
follicular lymphoma
rituximab
  • 8 views
  • 05 Jul, 2021
  • 5 locations
Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults

After consolidation therapy adult patients (18 yr) with Ph-negative ALL will be treated with continuation chemotherapy or allogeneic hematopoietic stem cell transplantation (alloHSCT) according to both measurable residual disease (MRD) and results of genetic study performed at baseline.

cell transplantation
consolidation therapy
residual tumor
  • 1 views
  • 22 Feb, 2021
  • 91 locations
CCCG-HD-2018 for Children and Adolescents With Newly Diagnosed Hodgkin Lymphoma

The incidence of Hodgkin's lymphoma (HL) in Chinese children and adolescents is only 1 / 10 of that in Europe and the United States, which is a "rare" childhood tumor. Due to the "drug shortage" and extremely low incidence, it has brought great difficulties to the domestic clinical research and …

  • 0 views
  • 05 Feb, 2021
  • 3 locations
Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years)

The protocol objective is providing adequate treatment and based on broad consensus in elderly patients with Acute Lymphoblastic Leukemia (ALL). Apply uniform treatment that enables a joint analysis of results strong enough to make conclusions on specific subgroups of patients (genotypic subtypes, particularly LAL Bcr/abl positive, phenotype, or strata of …

lymphoid leukemia
methotrexate
bcr-abl protein
idarubicin
ara-c
  • 28 views
  • 02 Feb, 2021
  • 1 location
Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

This partially randomized phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. Monoclonal antibodies, such as inotuzumab ozogamicin, may block cancer growth in different ways by targeting certain cells. …

asparaginase
corticosteroids
direct bilirubin
daunorubicin
imatinib
  • 45 views
  • 25 Jul, 2021
  • 473 locations
Efficacy and Safety of Lenalidomide Plus CHOP vs CHOP in Patients With Untreated Peripheral T-Cell Lymphoma

This study aims to compare the efficacy and safety of lenalidomide plus CHOP (L-CHOP) versus CHOP alone in patients with previously untreated peripheral T-cell lymphoma (PTCL)

cyclophosphamide
anaplastic large cell lymphoma
large cell lymphoma
peripheral t-cell lymphoma
vincristine
  • 0 views
  • 24 Jul, 2021
  • 1 location
Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Pheochromocytoma/Paraganglioma

Primary Objective: To determine the response rate (RR) of metastatic or locally advanced pheochromocytoma/paraganglioma to axitinib administered daily. Secondary Objectives: Determine the progression-free survival. In an exploratory manner examine the extent of activation of the VEGFR pathway in pheochromocytoma/paraganglioma using a semi-quantitative immunohistochemistry assay and examine the relationship with response …

paraganglioma
pheochromocytoma
immunohistochemistry
metastatic disease
dotatate
  • 1 views
  • 22 Jan, 2021
  • 1 location
Efficacy and Safety of Sirolimus to Vascular Anomalies

To evaluate the safety and efficacy of Sirolimus in complicated vascular anomalies in Chinese children

  • 0 views
  • 26 Jan, 2021
  • 1 location
Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

This phase III trial compares the effect of usual treatment of chemotherapy and steroids and a tyrosine kinase inhibitor (TKI) to the same treatment plus blinatumomab. Blinatumomab is a Bi-specific T-Cell Engager ('BiTE') that may interfere with the ability of cancer cells to grow and spread. The information gained from …

  • 0 views
  • 02 Jul, 2021
  • 91 locations
DS-1594b With or Without Azacitidine Venetoclax or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia

This phase I/II trial studies the effect of DS-1594b with or without azacitidine, venetoclax, or mini-HCVD in treating patients with acute myeloid leukemia or acute lymphoblastic leukemia that has come back (recurrent) or not responded to treatment (refractory). Chemotherapy drugs, such as azacitidine, venetoclax, and mini-HCVD, work in different ways …

cyclophosphamide
chronic myelomonocytic leukemia
leukemia
hydroxyurea
methotrexate
  • 0 views
  • 14 Jul, 2021
  • 1 location