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Found 151 clinical trials
Study of Recombinant Human Endostatin Combined With CV Regimen in the Treatment of Pediatric Low-grade Gliomas

postpone or avoid radiotherapy. It is the preferred treatment for children with LGGs after surgery. Carboplatin combined with vincristine, the CV regimen, is currently the main chemotherapy regimen for the

  • 0 views
  • 24 Mar, 2021
  • 1 location
A Prospective Study for the Treatment of Children With Newly Diagnosed LCH Using a Cytarabine Contained Protocol

current study had a more intensive initial treatment regimen for RO- patients. However, the addition of etoposide to prednisone and vincristine in the initial therapy did not increase the 6-week response

  • 0 views
  • 06 Mar, 2021
  • 1 location
A Phase 1 Study of Romidepsin CC-486 (5-azacitidine) Dexamethasone and Lenalidomide (RAdR) for Relapsed/Refractory T-cell Malignancies

>Patients with systemic TCM are most commonly treated with a CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone)-like regimens, that produce long-term progression-free survival in

cyclophosphamide
revlimid
romidepsin
lenalidomide
vincristine
  • 0 views
  • 25 Jul, 2021
  • 1 location
Efficacy and Safety of CDOP vs CHOP for Newly Diagnosed Peripheral T-cell Lymphoma

Primary objective of the study is to compare the efficacy and safety of CDOP versus CHOP for newly diagnosed peripheral T-cell lymphoma (PTCL).

anaplastic large cell lymphoma
cyclophosphamide
t-cell lymphoma
large cell lymphoma
vincristine
  • 0 views
  • 23 Jan, 2021
  • 1 location
Nivolumab and Combination Chemotherapy in Treating Participants With Diffuse Large B-Cell Lymphoma

This phase I/II trial studies the side effects and best dose of nivolumab and how well it works when giving together with combination chemotherapy in treating participants with diffuse large B-cell lymphoma. Monoclonal antibodies, such as nivolumab, interfere with the ability of cancer cells to grow and spread. Drugs used …

cancer
cyclophosphamide
monoclonal antibodies
vincristine
measurable disease
  • 9 views
  • 04 Apr, 2021
  • 4 locations
Sirolimus Versus Sirolimus Plus Prednisolone for Kaposiform Hemangioendothelioma

Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm that occurs predominantly in infancy or early childhood. KHE has a nearly equal sex ratio. The annual incidence of KHE has been estimated at 0.071 per 100,000 children. KHE presents with intermediate-malignant and locally aggressive characteristics but without distant metastases. This pilot …

hemangioendotheliomas
vascular tumors
propranolol
neutrophil count
prednisolone
  • 48 views
  • 15 Mar, 2021
  • 1 location
Nivolumab With Standard of Care Chemotherapy for Peripheral T Cell Lymphomas

This regimen aims to become the first line treatment for peripheral T cell lymphoma, using nivolumab with the standard of care chemotherapy.

anaplastic large cell lymphoma
panniculitis
t-cell lymphoma
intestinal t-cell lymphoma
large cell lymphoma
  • 10 views
  • 05 Mar, 2021
  • 3 locations
Phase I Study of Inotuzumab With Augmented BFM Re-Induction for Younger Adults With Relapsed/Refractory B-cell ALL

In the proposed study, escalating doses of inotuzumab ozogamicin will be added to a standard pediatric inspired re-induction regimen and administered to younger adults with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). Two re-induction regimens will be tested (one without pegaspargase and one including pegaspargase) and participants will be …

remission
methotrexate
prednisone pill
pegaspargase
inotuzumab
  • 0 views
  • 25 Jan, 2021
  • 1 location
Rituximab Combination Chemotherapy and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed Follicular Non-Hodgkin Lymphoma

RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy work in different ways to stop the growth …

combination chemotherapy
cancer
cyclophosphamide
monoclonal antibodies
ibritumomab tiuxetan
  • 19 views
  • 07 Nov, 2020
  • 1 location
Combination Chemotherapy and Rituximab in Treating Patients With Primary Mediastinal Diffuse Large B-Cell Lymphoma

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. …

cancer
cyclophosphamide
methotrexate
monoclonal antibodies
etoposide
  • 22 views
  • 07 Nov, 2020
  • 5 locations