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Found 29 clinical trials
Brentuximab Vedotin and Nivolumab in Treating Patients With Early Stage Classic Hodgkin Lymphoma

This phase II trial studies how well brentuximab vedotin and nivolumab work in treating patients with stage I-II classic Hodgkin lymphoma. Brentuximab vedotin is a monoclonal antibody, brentuximab, linked to a toxic agent called vedotin. Brentuximab attaches to CD30 positive cancer cells in a targeted way and delivers vedotin to …

mixed cellularity hodgkin lymphoma
monoclonal antibodies
cancer
dacarbazine
vinblastine
  • 3 views
  • 15 Feb, 2022
  • 11 locations
Chemoradiotherapy With Targeted Immunotherapy in Pediatric Lymphoma (RADICAL)

The addition of targeted immunotherapy will be safe and well tolerated and facilitate the reduction of anthracycline exposure while preserving lymphoma disease control in children, adolescents and young adults (CAYA) with mature B-cell non-Hodgkin lymphoma (MB-NHL) and classical Hodgkin lymphoma (cHL).

lymphoma cells
vinblastine
chemotherapy regimen
dexamethasone
rituximab
  • 0 views
  • 29 Jun, 2022
  • 1 location
A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor

This is a phase I/II, open-label, non-randomized, multicentre study to evaluate the clinical activity of vactosertib plus imatinib in desmoid tumor. Based on the background, TGF-β inhibition as a potential therapeutic target for desmoid tumor and convey significant implications for the clinical development. Therefore, investigator will conduct the phase II …

ejection fraction
metastatic disease
imatinib
vactosertib
measurable disease
  • 46 views
  • 02 Jul, 2022
  • 1 location
Metronomic Treatment in Children and Adolescents With Recurrent or Progressive High Risk Neuroblastoma (METRO-NB2012)

Neuroblastoma is the second most frequent cause for death from cancer in childhood. Already one year after diagnosis of recurrence from high risk neuroblastoma, 75% of the patients experience further progression. Metronomic therapy is targeting not only the tumor cell, but also the tumor supplying vasculature and the interactions between …

neutrophil count
high-risk neuroblastoma
cancer
iobenguane
bone marrow procedure
  • 17 views
  • 25 Feb, 2022
  • 8 locations
Brentuximab Vedotin and BeEAM High-dose Chemotherapy in Lymphomas (BAL)

The trial assess the maximum tolerated dose of a single-dose of Brentuximab Vedotin added to standard BeEAM chemotherapy (comprising Bendamustin, Etoposide, Cyclophosphamide and Melphalan) before autologous stem cell transplantation in CD30+ malignant lymphomas.

t-cell lymphoma
neutrophil count
solid tumor
etoposide
platelet count
  • 4 views
  • 10 Mar, 2022
  • 1 location
NETs: Protection or Harm in Neonatal Inflammation or Infection

This is a prospective in vitro cell biology study of polymorphonuclear leukocyte (PMN) protein synthesis in response to PAF. PMNs from cord blood of premature human infants at risk for NEC (birth weight between 501 - 1500 grams) and PMNs from cord blood of healthy term infants will be isolated …

Accepts healthy volunteers
  • 3 views
  • 21 Apr, 2022
  • 1 location
Diagnostic of Chemotherapy Induced Neuropathy in Children

The purpose of this study is to determine the diagnostic accuracy of a newly developed tool (Electrochemical Skin Conductances (ESC) measurement) easy-to-perform, non-invasive, highly reproductible and not requiring specific training, to identify pediatric chemotherapy-induced-peripheral-neuropathies (CIPN). CIPN are a frequent (20 to 75% depending on the drug), early and potentially severe …

neuralgia
taxane
alkaloids
carboplatin
oxaliplatin
  • 0 views
  • 15 Dec, 2021
  • 1 location
Specified Drug Use Surveillance for ADCETRIS Intravenous Infusion 50 mg -Untreated CD30 Positive Hodgkin Lymphoma (Pediatric)

myelosupression, peripheral neuropathy, and lung disorder. During the study, pediatric participants with HL will take Brentuximab Vedotin injection and AVD treatment (doxorubicin hydrochloride, vinblastine

  • 0 views
  • 18 Sep, 2022
  • 1 location
A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With Systemic ALK(+) ALCL

With the development of molecular biology and precise medical treatment, new challenges have been raised in the diagnosis and treatment of non-Hodgkin lymphoma (NHL) in children. In recent years, the criteria for clinical staging and efficacy evaluation of NHL in children have been updated. Studies in Germany and the United …

hodgkin's disease
anaplastic large cell lymphoma
lymphoma
  • 3 views
  • 28 May, 2022
  • 1 location