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Found 67 clinical trials
Effect of EIT-guided PEEP Titration on the Prognosis of Patients With Moderate to Severe ARDS

-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for

  • 0 views
  • 04 Oct, 2022
  • 1 location
First-In-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALT-100

ALT-100 is a monoclonal antibody developed by Aqualung Therapeutics Corp. as a treatment for Acute Respiratory Distress Syndrome (ARDS). ARDS can occur as a serious complication in patients with respiratory infections such as COVID-19 and Influenza or have acquired trauma to their lungs. 32 healthy male or female participants between …

covid-19
acute respiratory distress
Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Assessment of Regional Lung Ventilation Distribution During Supraglottic and Subglottic Jet Ventilation by EIT.

Objective: To estimate regional lung volume changes by electrical impedance tomography (EIT) during supra- and subglottic jet ventilation via the jet laryngoscope and LaserJet catheter for performing laryngotracheal surgery. Design: A monocentric, prospective, randomized study. Patients: Patients who require elective micro laryngo-tracheal surgery under jet ventilation. Interventions: Patients undergoing elective …

  • 0 views
  • 07 Oct, 2022
  • 1 location
Pressure Support Ventilation During Laparoscopic and Abdominal Robotic Surgery.

This study is a single-center, blind, prospective, randomized, controlled trial of pressure support ventilation (PSVpro) versus pressure control ventilation - volume guaranteed (PCV - VG) during laparoscopic and robotic abdominal surgery.

  • 0 views
  • 02 Apr, 2021
  • 1 location
Assessing Ventilator Safety in Patients on Pressure-Support Ventilation (ASOP)

ASOP is a prospective cohort study comparing three methods for assessing risk of self-induced lung injury in patients with acute respiratory failure being managed with pressure-support ventilation. We will describe the relationship between three different assessment methods for risk of self-induced lung injury and compare them to a gold standard …

mechanical ventilation
  • 0 views
  • 21 Mar, 2022
  • 1 location
Enhanced Lung Protective Ventilation With ECCO2R During ARDS (PROVE)

Acute Respiratory Distress Syndrome (ARDS) is associated with a mortality rate of 30 - 45 % and required invasive mechanical ventilation (MV) in almost 85 % of patients[1]. During controlled MV, driving pressure (i.e., the difference between end-inspiratory and end-expiratory airway pressure) depends of both tidal volume and respiratory system …

assisted breathing
respiratory distress
renal replacement therapy
aeration
FIO2
  • 19 views
  • 04 Oct, 2022
  • 1 location
Effects of Large Tidal Volumes Despite Minimal Inspiratory Support in Spontaneously Ventilated Intubated Resuscitation Patients. Pathophysiological Exploratory Study.

Some ICU ventilated patients might present with large tidal volume despite very low or inexistant presser support. Patient-Self Inflicted Lung Injury (P-SILI) might appear related with large alveolar stretch an distension. Two clinical presentations are observed: patients with or without respiratory distress signs such as supra-clavicular depression and thoracic-abdominal asynchronies. …

positive end expiratory pressure
mechanical ventilation
  • 0 views
  • 06 Oct, 2021
  • 1 location
Clinical Decision Support Tool in PARDS Pilot Study

Previous clinical trials in adults with acute respiratory distress syndrome (ARDS) have demonstrated that ventilator management choices can improve Intensive Care Unit (ICU) mortality and shorten time on mechanical ventilation. This study seeks to scale an established Clinical Decision Support (CDS) tool to facilitate dissemination and implementation of evidence-based research …

assisted breathing
acute respiratory distress
mechanical ventilation
  • 0 views
  • 16 Aug, 2021
  • 8 locations
Ultraprotective Ventilation Without Extracorporeal Circulation During COVID 19 Pneumonia

appears to exceed standard duration of mechanical ventilation in non-COVID-19 ARDS patients, suggesting that COVID-19 patients may be particularly at risk for ventilator-induced lung injury. Treatment of

  • 0 views
  • 25 Feb, 2021
  • 11 locations
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations (BBESPB)

Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain. Development and implementation in clinical practice perioperative intensive care protocols for surgical correction of spinal deformities.

epinephrine
dexamethasone
acute pain
intubation
bupivacaine
  • 0 views
  • 07 Oct, 2022
  • 1 location