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Found 16 clinical trials
Treatment of Chronic Hepatitis C During Pregnancy With Sofosbuvir/Velpatasvir

A single-arm, single-center, open label Phase 1 study of a 12-week course of Sofosbuvir (SOF)/Velpatasvir (VEL) in 10 HCV-infected pregnant women 1 that will evaluate the plasma pharmacokinetic

hepatitis b
chronic hepatitis
sofosbuvir
velpatasvir
  • 0 views
  • 26 Jan, 2021
  • 1 location
Combined Ribavirin With Sofosbuvir/Velpatasvir/Voxilaprevir in Retreatment of Chronic Hepatitis C Non-responders

This study aims to assess the role of ribavirin as an adjuvant to sofosbuvir/velpatasvir/voxilaprevir combination in retreatment of chronic hepatitis C with previous treatment failure.

  • 0 views
  • 28 Jan, 2021
  • 1 location
Re-treatment of HCV Following DAA Failure

velpatasvir [VEL]). Globally, DAA based regimens have obtained excellent rates of cure. Cure of HCV infection is defined as undetectable HCV RNA 12 weeks after stopping drugs, also referred to as sustained

liver disease
sofosbuvir
velpatasvir
cirrhosis
ledipasvir
  • 19 views
  • 11 Apr, 2021
  • 2 locations
The Kentucky Viral Hepatitis Treatment Study

The overarching goal of the Kentucky Viral Hepatitis Treatment Project (KeY Treat) is to increase hepatitis C virus (HCV) treatment access and delivery in a rural Appalachian community, which is in the midst of the opioid/hepatitis C (HCV) syndemic. KeY Treat is a clinical research study seeking to determine whether …

viral hepatitis
sofosbuvir
velpatasvir
sofosbuvir/velpatasvir
epclusa
  • 7 views
  • 23 Jan, 2021
  • 1 location
Sofosbuvir/Velpatasvir in Postpartum Women With Opioid Use Disorder and Chronic Hepatitis C Infection

of sofosbuvir/velpatasvir therapy initiated at 2 weeks postpartum. Feasibility/acceptability and adherence to sofosbuvir/velpatasvir will be assessed at 4, 8 and 12 weeks of therapy. In Phase 3

hepatitis b
chronic hepatitis
sofosbuvir
velpatasvir
  • 44 views
  • 25 Jan, 2021
  • 1 location
Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy

/velpatasvir (SOF/VEL, Epclusa), followed then by switch to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF, Biktarvy) for an additional 48 weeks.

methadone
elvitegravir
sofosbuvir
antiretrovirals
antiviral
  • 67 views
  • 23 Jan, 2021
  • 1 location
A TEst and Treat Intervention aMong Current People Who Inject Drugs With HCV Attending Needle and Syringe PrOgrams

/Velpatasvir. Of those who initiate treatment, participants will receive weekly peer-based support on-treatment and return at End of Treatment (ETR) and 12 weeks following end of treatment (SVR12) for clinical

drug use
sofosbuvir
glecaprevir
velpatasvir
pibrentasvir
  • 1 views
  • 02 Mar, 2021
  • 1 location
Expanding the Pool in Orthotopic Heart Transplantation

This is an open-label, pilot trial to test the safety and efficacy of transplantation of hearts from HCV seropositive non-viremic (HCV Ab+/NAT-) and HCV seropositive viremic (HCV Ab+/NAT+) donors to HCV seronegative recipients on the heart transplant waitlist. Treatment and prophylaxis will be administered, using a transmission-triggered approach for the …

organ transplantation
hepatitis c antibody
sofosbuvir
velpatasvir
drugs of abuse
  • 23 views
  • 27 Jan, 2021
  • 1 location
The Use of Hepatitis C Positive Livers in Hepatitis C Negative Liver Transplant Recipients

This is an open-label, pilot trial to test the safety and efficacy of transplantation of livers from Hepatitis C seropositive non-viremic (HCV Ab+/NAT-) and HCV seropositive viremic (HCV Ab+/NAT+) donors to HCV seronegative recipients on the liver transplant waitlist. Treatment and prophylaxis will be administered, using a transmission-triggered approach for …

hepatitis c antibody
sofosbuvir
velpatasvir
immune globulin
hepatitis
  • 1 views
  • 26 Jan, 2021
  • 1 location
Utilization of Hepatitis C Positive Kidneys in Negative Recipients

To evaluate the safety and feasibility of transplanting kidneys from Hepatitis C virus (HCV) infected donors into recipients without HCV infection

  • 0 views
  • 22 Jan, 2021
  • 1 location