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Found 277 clinical trials
Salvage Therapy With Sunitinib Docetaxel and Platinum on Metastatic or Unresectable Non Small Cell Lung Cancer

vascular endothelial growth factor (VEGF) receptors. Besides, the expression of the VEGF ligands is also correlated with increased tumor angiogenesis, as well as shortened survival time. One

solid tumour
docetaxel
bevacizumab
lung carcinoma
measurable disease
  • 2 views
  • 08 Nov, 2020
  • 1 location
VASCular Impact of Angiogenic Treatment in Patients With Advanced Colorectal Cancer

-dependent neoangiogenesis (vascular endothelial growth factor VEGF). In the reference studies, the inhibition of VEGF, whether extracellular (monoclonal antibody directed against VEGFA) or intracellular

  • 0 views
  • 03 Apr, 2021
  • 1 location
Modulation of Tissue Sodium in Hemodialysis Patients

dialysis session. Tissue Na+ mobilization correlated with circulating vascular endothelial growth factor-C (VEGF-C). The investigators believe that excessive Na+ storage is a reversible condition and

  • 9 views
  • 27 Jan, 2021
  • 1 location
Phase II Study of RAD001 in a Neoadjuvant Setting in Men With Intermediate or High Risk Prostate Cancer

for phosphorylated p70S6K , pS6, Akt as well as antibodies for VEGF, BCL2 and PTEN in prostate cancer tissues before and after 6 weeks RAD001 treatment will be performed. Additionally

adenocarcinoma of prostate
tumor progression
PTEN
adenocarcinoma
castration-resistant prostate cancer
  • 3 views
  • 07 Nov, 2020
  • 1 location
Physical Exercise and Responses Measured by HIF-1 in COPD

on the synthesis of EPO and VEGF and its relationship with spirometric and hematological tests have not been studied in COPD people who live in medium altitudes and who are additionally exposed to

  • 0 views
  • 17 Jul, 2021
  • 1 location
NPC - AXEL Study : Axitinib-Avelumab

highly potent and selective inhibitor of VEGF receptor. Selectively targeting a single growth factor receptor pathway provides the potential to rationally adjust dosages and combine drugs directed at

  • 0 views
  • 14 May, 2021
  • 1 location
Changes in Inflammatory Biomarkers Including Soluble CD14 and Hyperreflective Foci in DME Patients Treated With Aflibercept (FORESIGHT)

This study evaluates the effect of aflibercept on the change of cytokines incluing sCD14, MCP-1, IL-6, and ICAM-1 in the aqueous humor of DME patients. Additionally, changes of visual acuity (ETDRS), optical coherence tomography parameters including hyperreflective foci and thickness of macula are also investigated.

aflibercept injection
optical coherence tomography
cytokines
diabetes
aflibercept
  • 0 views
  • 25 Jan, 2021
  • 1 location
Combination of Ranibizumab and Targeted Laser Photocoagulation

Intravitreal injections of Ranibizumab will be applied in all patients according to treatment guidelines. The experimental group will receive additional targeted laser photocoagulation of the peripheral areas of capillary non-perfusion (up to 4 laser treatments within 1st year of the study). Based on the long-term observation after CoRaLa I study …

  • 0 views
  • 25 Jan, 2021
  • 8 locations
A Phase II Study of RBM-007 Alone and RBM-007 With Eylea in Subjects With Wet Age-related Macular Degeneration

This is a multicenter, active-controlled, double masked study assessing the safety, efficacy and durability of four monthly intravitreal (IVT) injections of RBM-007 monotherapy, and four monthly RBM-007 injections in combination with Eylea dosed at every other month, compared to Eylea monotherapy dosed at every other month in approximately eighty-one subjects …

eylea
optical coherence tomography
atrophy
edema
age-related macular degeneration
  • 17 views
  • 06 Jul, 2021
  • 8 locations
Central Retinal Vein Occlusion (CRVO) Treatment With Bevacizumab and Dexamethasone or Bevacizumab Only.

The purpose of this study is to determine whether Bevacizumab (Avastin) in combination with Dexamethasone (Ozurdex) will be effective in reducing if not eliminating the macular edema associated with the disease, central retinal vein occlusion (CRVO) in comparison to Bevacizumab (Avastin) alone.

  • 0 views
  • 25 Jan, 2021
  • 1 location