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Found 275 clinical trials
Biomarkers in Polyradiculoneuropathies

The nodes of Ranvier contain ion channels that enable the rapid propagation of the nerve impulse. Cell adhesion molecules and glycolipids play an important role in the formation of the nodes of Ranvier. Antibodies against glycolipids are detected in half of patients with Guillain-Barr syndrome, an acute inflammatory neuropathy affecting …

inflammatory neuropathy
cell adhesion molecules
adhesion
neuromuscular diseases
polyradiculoneuropathy
  • 14 views
  • 24 Jan, 2021
  • 1 location
BIOREN (Predictive BIOmarkers in Metastatic RENal Cancer)

The BIOREN project aims are to characterize the genetic background of renal cell carcinomas and their immune environment, to try and identify biomarkers of response and to better understand the mechanisms of resistance to nivolumab in renal cancer.

  • 0 views
  • 18 Feb, 2021
  • 1 location
Inflammatory Pathways and Cardiac Growth Factors Associated With Fabry Disease Cardiomyopathy

In Fabry disease (FD), -galactosidase A deficiency leads to the accumulation of globotriaosylceramide (Lyso-Gb3 and Gb3), triggering a pathologic cascade that causes progressive damage to multiple organs, including the heart. The heart is one of the organs that is very sensitive to the deficiency of -galactosidase A. There is a …

  • 0 views
  • 05 Feb, 2021
  • 1 location
Multi-Tracer PET Assessment of Primary Brain Tumors

The standard treatment approach for patients with high-grade primary brain tumors includes maximum feasible surgical resection, followed by 6 weeks of concurrent cranial irradiation and daily low-dose temozolomide chemotherapy, followed by 12 cycles of high-dose temozolomide administered for 5 consecutive days every 4 weeks [Stupp 2005]. Contrast-enhanced MRI is the …

recurrent tumor
histological diagnosis
temozolomide
karnofsky performance status
primary brain tumors
  • 6 views
  • 26 Jan, 2021
  • 1 location
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection

The purpose of this study is to examine gene expression profiles by DNA microarray in patients who are responders and non-responders to interferon and ribavirin treatment for hepatitis C virus (HCV). Genes involved in inflammation and fibrosis and mediators of the Th-1 lymphocyte response will be looked for. It is …

ribavirin
mono
chronic hepatitis
interferon
fibrosis
  • 47 views
  • 07 Nov, 2020
  • 1 location