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Found 86 clinical trials
Safety and Efficacy of HA380 Hemoadsorption in Patients With Septic Shock

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Intensive care unit (ICU) mortality in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) remains high and approximates 50-60%. Sepsis is the leading etiology for AKI and CRRT …

renal replacement therapy
  • 20 Aug, 2021
  • 1 location
A Trial of Vitamin B12 in Septic Shock

This study will randomize 20 septic shock patients to receive either a single 5 gram dose of IV vitamin B12 (Cyanokit® Meridian Medical Technologies, Columbia, MD) versus placebo in addition to standard of care to test the feasibility of completing clinical and laboratory protocols.

  • 22 Dec, 2021
  • 1 location
HAT for the Treatment of Sepsis Associated With NASTI

Evaluate the impact of HAT therapy versus placebo in the treatment of patients with an acute NSTI and sepsis.

  • 22 Dec, 2021
  • 1 location
Cardiac Output Response to Vasopressin Infusion In Abdominal Surgery Patients Under Mechanical Ventilation

In this study, the investigators propose to explore the hemodynamic variations induced by vasopressin and its influence on cardiac output, mean systemic pressure, and venous return resistance measured through cardiopulmonary interactions, according to the approach proposed by Guyton, in patients undergoing major abdominal surgeries.

  • 07 Jul, 2021
  • 1 location
The GUARDIAN Pilot Trial

The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP 85 mmHg, delayed resumption of chronic antihypertensive medications, and a target ward MAP 80 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management and prompt resumption of chronic antihypertensive medications (routine pressure management).

  • 29 May, 2021
  • 1 location
Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension in Patients Undergoing Caesarean Section: A Randomized Sequential Allocation Dose-finding Study.

The purpose of this study is to investigate the potency between prophylactic norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in patients undergoing caesarean section.

  • 21 Sep, 2022
  • 1 location
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study (TIGRIS)

Prospective, multicenter, randomized, open-label study of standard of care plus the PMX cartridge versus standard of care alone in patients with endotoxemic septic shock

positive pressure ventilation
septic shock
  • 07 Jul, 2022
  • 15 locations
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients

Delirium is one of the most common manifestations of cerebral dysfunction in severely ill patients. The international guidelines for the prevention of delirium in intensive care recommend the daily application of environmental, behavioral and pharmacological strategies. In the case of the agitated form of delirium, experts recommend the use of …

  • 25 Feb, 2021
  • 3 locations
ASpirin for Patients With SEPsis and SeptIc Shock (ASP-SEPSIS)

This Randomized, pragmatic, multicentric with blinding of patients and health professionals, intention-to-treat analysis has by primary endpoint to evaluate whether the aspirin use reduces the intensity of organic dysfunction measured by the variation of the SOFA score starting from the day of admission to the seventh day. Secundary endpoint: To …

mechanical ventilation
septic shock
  • 03 May, 2022
  • 1 location
Chimeric Antigen Receptor (CAR) T Cell Therapy With YESCARTA in the Outpatient Setting

We hope to demonstrate that YESCARTA can be safely administered in the outpatient setting if we closely monitor subjects with physical exams, wearable devices, and telemedicine visits and only admit those who meet specified criteria

Accepts healthy volunteers
  • 24 Jul, 2022
  • 1 location