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Found 84 clinical trials
Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock

, could prevent progressive organ dysfunction and reduce vasopressor use in patients with severe sepsis and septic shock. Its effect on mortality, on the other hand, is yet to be demonstrated. The

severe sepsis
corticosteroids
vitamins
vasoconstrictors
septic shock
  • 0 views
  • 25 Mar, 2022
  • 1 location
The GUARDIAN Trial

The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP 85 mmHg, delayed resumption of chronic antihypertensive medications, and a target ward systolic pressure 110 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management and prompt resumption of chronic antihypertensive medications (routine pressure management).

  • 0 views
  • 28 Aug, 2021
  • 3 locations
Intravenous Thyroxine for Heart-Eligible Organ Donors

This randomized controlled trial will evaluate whether intravenous thyroxine infusion given to brain-dead organ donors who are eligible to donate hearts for 12 hours will result in more hearts transplanted than saline placebo

inotropic agent
  • 0 views
  • 08 Dec, 2021
  • 14 locations
Australasian COVID-19 Trial (ASCOT) ADAptive Platform Trial (ASCOT ADAPT)

An International Multi-Centre Randomised Adaptive Platform Clinical Trial to Assess the Clinical, Virological and Immunological Outcomes in Patients with SARS-CoV-2 Infection (COVID-19).

  • 871 views
  • 11 Aug, 2022
  • 18 locations
Rapid Recognition of Corticosteroid Resistant or Sensitive Sepsis (RECORDS)

Main objective and primary endpoint: To compare the effect hydrocortisone plus fludrocortisone vs. placebo on a composite of death or persistent organ dysfunction - defined as continued dependency on mechanical ventilation, new renal replacement therapy, or vasopressors - assessed at 90 days on intensive care unit (ICU) adults and having …

corticosteroids
pao2
vasoconstrictors
lactate level
secondary infection
  • 0 views
  • 23 May, 2022
  • 1 location
Mini Bolus for Fluid Challenge Responsiveness in the Emergency Department (MIBORED)

Intravascular volume expansion is a common intervention in critically ill patients with acute circulatory failure.we test the hypothesis that a mini-bolus fluid challenge, of either 50 ml or 100 ml, can predict fluid responsiveness in spontaneously breathing patients with hemodynamic instability.

  • 0 views
  • 27 May, 2022
  • 1 location
PVP-Guided Decongestive Therapy in HF (PERIPHERAL-HF)

The investigators hypothesize that a simple assessment of peripheral venous pressure (PVP) will better predict the diuretic need and long-term outcomes (all cause mortality, all cause rehospitalization, emergency department visits) compared to standard evaluation.

chronic heart failure
heart failure
diuretic therapy
  • 0 views
  • 23 Mar, 2022
  • 2 locations
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients (CONFIDENCE)

Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients. Lung ultrasound (LUS) is an easy to learn, safe, cheap and noninvasive bedside imaging tool with high accuracy for pulmonary edema and pleural effusions in ICU patients. The aim of …

  • 3 views
  • 23 Mar, 2022
  • 1 location
Direct or Subacute Coronary Angiography in Patients With Out of Hospital Cardiac Arrest Without Coma.

In patients with Out-of-Hospital Cardiac arrest who achieves Return Of Spontaneous Circulation (ROSC) The investigators want to evaluate whether there is a benefit from acute Angiography compared to su bacute (12-24 hours) Angiography

  • 0 views
  • 16 May, 2021
  • 1 location
Conservative Versus Conventional Oxygen Administration in Critically Ill Patients

Oxygen supplementation in the inspired mixture is commonly used in critically ill patients and observational studies highlight that those patients remain hyperoxemic for substantial periods during Intensive Care Unit stay. However, exposure to inhaled oxygen-enriched mixtures is widely recognized as potentially harmful and cause of organ damage. Although, the specific …

FIO2
pao2
pulse oximetry
critical illness
mechanical ventilation
  • 2 views
  • 21 Feb, 2022
  • 1 location