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Found 122 clinical trials
A Pilot Study in Severe Patients With Takayasu Arteritis.

Takayasu arteritis (TAK) is a rare chronic inflammatory arteritis, which lacks an effective well-accepted intervention strategy. We classify TAK patients into 3 levels, including mild, moderate, and severe. And the biological agents tocilizumab and adalimumab are randomly prescribed in severe patients, to find out the relatively better treatment strategy, facilitating …

  • 26 Jan, 2021
  • 1 location
Phenotypic and Functional Characterisation of Human B-cell Response in Pemphigus

Pemphigus is a rare autoimmune disease involving skin and mucous membranes characterized by the production of pathogenic autoantibodies directed against desmosomal transmembrane glycoproteins belonging to the cadherin family,responsible for the disruption of desmosomes leading to the acantholysis phenomenon.Two main classical subtypes of pemphigus have been individualized:pemphigus vulgaris and foliaceus,in which …

autoimmune disease
rheumatoid arthritis
  • 28 Jan, 2021
  • 2 locations
Effect of Ozone Therapy for the Treatment of Digital Ulcer in Patients With SSc

Functionality in patients with SSc? Systemic Sclerosis (SSc) is a chronic connective tissue disease characterized by microvascular involvement, immunological dysfunction, extracellular matrix deposition in the skin and internal organ involvement. Vascular disease has an important role in the pathogenesis of SSc. Especially as a result of involvement of micro-vessel and …

digital ulcer
vascular disease
  • 02 Jun, 2021
  • 1 location
Immunoassay and Regulation of Traditional Chinese Medicine on Cancer Patients

The immune system is our body's defense mechanism, which helps us to resist foreign pathogens and cancer cells in the body. However, if the immune system is too weak, too strong, or unbalanced, it will be susceptible to get bacterial and viral infections, unable to fight cancer, or cause allergies, …

breast cancer
cancer of the ovary
cancer chemotherapy
ovarian cancer
  • 24 Jan, 2021
  • 1 location
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.

The purpose of this study is to determine whether nitric oxide is effective in the treatment of acute kidney injury in cardiac surgical patients with sign and laboratory data suggesting endothelial dysfunction undergoing prolonged cardiopulmonary bypass.

renal replacement
heart surgery
cardiopulmonary bypass
renal injury
replacement therapy
  • 07 Mar, 2021
Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

In this pilot and feasibility study, the investigators will enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) in a cross-over study testing two different classes of anti arrhythmic drugs (AADs). This pilot and feasibility study will provide preliminary data for a larger study in which the investigators will …

antiarrhythmic drug
  • 29 Apr, 2021
  • 4 locations
Monitoring Large Vessel Vasculitis With PET/MR Imaging

Large vessel vasculitis (LVV) causes blood vessel inflammation leading to pain, fatigue and complications such as aneurysm formation and stroke. Treatments used can have significant side-effects

  • 27 Mar, 2021
  • 1 location
Plasmapheresis Before Rituximab in Cryoglobulinemia

Initial worsening following initiation of rituximab therapy in patients with cryoglobulinemic vasculitis was described in 3.6% of cases. This worsening is often a serious condition, with high

  • 28 Jan, 2021
  • 1 location
Mepolizumab Long-term Study to Assess Real World Safety and Effectiveness of Eosinophilic Granulomatosis With Polyangiitis (EGPA) in Japan

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as the Churg-Strauss syndrome, is a systemic necrotizing vasculitis that affects small and medium sized blood vessels. NUCALA

  • 14 Jun, 2021
  • 15 locations
Pilot Study of the Impact of Giant Cell Arteritis and Its Treatment on the Autonomy of the Elderly in the First Year of Care

Giant cell arteritis is the leading cause of vasculitis in the elderly. No work evaluates its impact on autonomy. At the diagnosis a gerontological evaluation will be carried out including the

  • 26 Mar, 2021
  • 1 location