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Found 123 clinical trials
Comparison of ANCA and Anti-GBM Auto-antibodies Removal Kinetics Between Plasma Exchanges and Immunoadsorption in Patients With ANCA-associated Vasculitis or Anti-GBM Disease

Anti-neutrophil cytoplasmic antibodies (ANCA), directed against myeloperoxidase (MPO) and against proteinase 3 (PR3), have a pathogenic role during ANCA (AAV) vasculitis. Glomerular basement

renal impairment
immunosuppressive agents
coagulopathy
  • 0 views
  • 23 Jan, 2021
  • 1 location
Infliximab Therapy for Dolichoectactic Vertebrobasilar Aneurysms

Patients harboring dolichoectactic vertebrobasilar (DVB) aneurysms are at risk of suffering SAH, ischemic stroke, and/or brainstem compression and many patients are not offered invasive treatment due to the futility of existing surgical methods. Consequently, there is demand for development of medical therapy for DVB aneurysms

ischemic stroke
aneurysm
stroke
invasive treatment
  • 2 views
  • 23 Jan, 2021
  • 1 location
MEthotrexate Versus TOcilizumab for Treatment of GIant Cell Arteritis: a Multicenter Randomized Controlled Trial

Giant-cell arteritis (GCA) is the most frequent vasculitis after 50 years. It is characterized by a granulomatous inflammation of the wall of large vessels, involving especially the aorta and

glucocorticoids
stiffness
methotrexate
positron emission tomography
polymyalgia
  • 3 views
  • 13 May, 2021
  • 1 location
Autologous Peripheral Blood Stem Cell Transplant for Neurologic Autoimmune Diseases

This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a peripheral blood stem cell transplant works in treating patients with autoimmune neurologic disease that did not respond to previous therapy. In autoimmune neurological diseases, the patient's own immune …

cell counts
spinal cord
stiff person syndrome
peripheral neuropathy
malignancy
  • 154 views
  • 26 Apr, 2021
  • 3 locations
Specific Anti-HBV Vaccine Response After Vaccination in Patients Requiring Anti-CD20 Monoclonal Antibodies

neurological pathologies, systemic vasculitis or autoimmune disease and who need to receive anti-CD20 antibodies if the combination of injections over a short period is likely to promote immunization.

  • 0 views
  • 12 Feb, 2021
  • 1 location
Giant Cell Arteritis and Anakinra Trial

SYNOPSIS The giant cell arteritis (GCA) is the most frequent vasculitis in people over 50 years. Despite recent progress and physiopathogenic, corticosteroids remains the standard treatment for

prednisone
vasculitis
steroid therapy
tumor necrosis factor alpha
aortitis
  • 2 views
  • 24 Jan, 2021
  • 1 location
Belimumab With Rituximab for Primary Membranous Nephropathy

erythematosus (also referred to as lupus or SLE). Rituximab is approved by the FDA to treat some types of cancer, rheumatoid arthritis, and vasculitis. Neither rituximab nor belimumab is approved by the FDA to

systemic lupus erythematosus
angiotensin
nephropathy
glomerular filtration rate
nephrotic syndrome
  • 206 views
  • 28 Jan, 2021
  • 10 locations
The Assessment of Prednisone In Remission Trial - Centers of Excellence Approach

This study is a multi-center randomized controlled trial to evaluate the effects of using low-dose prednisone as compared to stopping prednisone treatment entirely. Participants will be randomized 1:1 to taper their prednisone dose down to 5 mg/day or to 0 mg/day for the duration of the study (approximately six months) …

trimethoprim
6-mercaptopurine
urinary sediment
anca
proteinase
  • 2 views
  • 18 Apr, 2021
  • 10 locations
Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease

The purpose of this study is to find if Etanercept can improve the outcome of ocular lesions of Behcet's Disease treated with Methotrexate and Prednisolone

vasculitis
methotrexate
uveitis
  • 2 views
  • 07 Nov, 2020
  • 1 location
Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis.

The purpose of this study is to investigate, after achievement of remission, the efficacy of rituximab compared with azathioprine maintenance therapy on duration of remission, in patients with relapsing or newly-diagnosed Eosinophilic granulomatosis with polyangiitis EPGA receiving standard of care therapy including glucocorticoid therapy reduction/withdrawal.

prednisone
vasculitis
anca
remission
rituximab
  • 0 views
  • 26 May, 2021
  • 1 location