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Found 123 clinical trials
Sensitivity and Specificity of Color Doppler Directed Temporal Artery Biopsy as Compared to Standard Random Biopsy in the Diagnosis of Temporal Arteritis

Introduction Temporal arteritis (TA) is the most common primary vasculitis in the adult population. TA is a systemic multi-organ disease but primarily involves the cranial arteries

  • 07 Nov, 2020
  • 1 location
Efficacy and Safety of Rituximab in the Treatment of Good Prognosis Microscopic Polyangiitis

The purpose of the study is to determine wether a rituximab-based treatment compared to standard therapy (glucocorticoid alone) in patients with microscopic polyangiitis without any bad prognosis marker increases the remission and reduces the relapse free survival rate.

  • 26 Apr, 2021
  • 1 location
Chewing Gum Test for the Diagnosis of Giant Cell Arteritis (Horton's Disease) - ChewingHort

It is hypothesized that chewing-gums may be a useful test to unmask jaws intermittent claudication in order to enhance the diagnosis of Giant Cell Arteritis (GCA).

horton syndrome
temporal arteritis
intermittent claudication
  • 23 Jun, 2021
  • 1 location
Intraorbital Injection Versus Oral Steroid in Anterior Idiopathic Orbital Inflammation

A multicenter randomised double-arm clinical trial, to compare safety and efficacy of oral versus intralesional injection of steroid in a group of patients suffering from idiopathic orbital inflammation is designed. Outcome measures include number of recurrences, duration of remission, and side effects.

  • 13 Feb, 2021
  • 1 location
Nasal Septum Perforation Treatment Using Tissue Engineered Cartilage Graft

The purpose of this study is to investigate the safety and feasibility of implanting an engineered cartilage tissue in an interposition graft with a temporoparietal fascia (TPF) flap to repair medium size septal perforation. The engineered cartilage graft is obtained by culturing expanded autologous nasal chondrocytes within a collagen type …

  • 15 May, 2021
  • 1 location
Abatacept for the Treatment of Relapsing Non-Severe Granulomatosis With Polyangiitis (Wegener's)

Multi-center, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of abatacept to achieve sustained glucocorticoid-free remission in patients with relapsing non-severe granulomatosis with polyangiitis (Wegener's) (GPA) . Participants will be randomized 1:1 to receive either abatacept 125 mg or placebo administered by subcutaneous injection once a week. Participants will continue …

granulomatous inflammation
chest radiograph
churg-strauss syndrome
nasal discharge
anti-neutrophil cytoplasmic antibody
  • 28 Apr, 2021
  • 26 locations
COVID-19 CoronaVac in Patients With Autoimmune Rheumatic Diseases and HIV/AIDS

/dermatomyositis [PM/DM], systemic sclerosis [SSc], systemic vasculitis, and primary Sjgren's syndrome [pSS]) are particularly susceptible to infectious diseases due to autoimmune disorder itself and its treatment

HIV Vaccine
  • 21 May, 2021
  • 1 location
A Study to Evaluate Guselkumab for the Treatment of Participants With New-onset or Relapsing Giant Cell Arteritis

The primary purpose of this study is to evaluate the efficacy of guselkumab compared to placebo, in combination with a 26-week glucocorticoid (GC) taper regimen, in adult participants with new-onset or relapsing giant cell arteritis (GCA).

  • 20 Jun, 2021
  • 35 locations
Hydroxychloroquine in ANCA Vasculitis Evaluation

(ANCA) Vasculitis, a group of autoimmune diseases. Hydroxychloroquine and is an established, effective, safe and inexpensive therapy, widely used in other autoimmune diseases such as lupus and

  • 26 Jan, 2021
  • 3 locations
PRagmatic Analysis of Vitamin D in ANCA-Associated Vasculitis

This prospective study will assess if 12 months of vitamin D3 (cholecalciferol) supplementation, in patients with AAV (GPA, MPA, and EGPA) who have deficient or insufficient 25(OH)D3 status at enrollment, correlates with improved disease activity and/or lower frequency of relapse (compared to historical data and a previously conducted cross sectional …

vitamin d
anti-neutrophil cytoplasmic antibody
  • 26 Jan, 2021
  • 1 location