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Found 122 clinical trials
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Gut Microbiota and Behcet's Syndrome: a Dietary Intervention Trial (MAMBA Study)

Behcet's syndrome (BS) is an idiopathic, chronic, multi-systemic inflammatory disorder characterized by ocular disease, skin lesions, vascular, neurological and gastrointestinal involvement. A recent study showed a peculiar dysbiosis of gut microbiota (GM) in BS patients, with specific changes in the profiles of short-chain fatty acids, especially butyrate. Over the last …

short-chain fatty acids
inflammatory disorder
skin lesions
eye disease
mediterranean diet
  • 7 views
  • 07 Aug, 2021
  • 1 location
None
Golimumab for the Treatment of Refractory Behcet's Uveitis

The aim of this single-center prospective study is to evaluate the efficacy and safety of Golimumab GOL, fully humanized anti-tumor necrosis factor (TNF)- monoclonal antibody, in the treatment of refractory Uveitis of Behet's disease (BDU), to verify its effects on decreasing the dose of cortical steroids, and to determine whether …

monoclonal antibodies
monoclonal antibody
behcet's syndrome
uveitis
panuveitis
  • 2 views
  • 21 Mar, 2021
  • 1 location
None
Autologous Fat Grafting in the Treatment of Critical Limb Ischaemia

Critical Limb Ischaemia (CLI) is a condition characterized by chronic ischemic at-rest pain, ulcers, or gangrene for more than 2 weeks in one or both legs, attributable to objectively proven arterial occlusive disease.CLI is associated with a high risk of lower amputation, diminished quality of life and mortality. Revascularization by …

  • 0 views
  • 19 Feb, 2021
  • 1 location
None
MPA AUC Monitoring in Patients Receiving MMF for Diffuse Cutaneous or Pulmonary Involvement in Systemic Sclerosis

To define a target value of AUC MPA to improve the modified Rodnan score and / or respiratory impairment (DLCO or FVC) at one year in patients receiving MMF for the treatment of diffuse cutaneous or interstitial lung damage of systemic sclerosis.

cyclophosphamide
progressive systemic sclerosis
pulmonary involvement
chest x-ray
scleroderma
  • 0 views
  • 25 Jan, 2021
  • 1 location
None
The ASSESS National Multi-center Prospective Cohort

The ASSESS national multi-center prospective cohort (Assessment of Systemic complications (Signs) and Evolution in Sjgren's Syndrome "SS") was set up in 2006 thanks to a grant of the French Ministry of Health. Fifteen centers for autoimmune diseases consecutively included consecutive patients with Primary Sjgren's Syndrome "pSS" fulfilling American-European Consensus Criteria …

  • 1 views
  • 24 Jan, 2021
  • 3 locations
None
Pharmacokinetics Pharmacodynamics and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to …

SARS
  • 1382 views
  • 25 Jan, 2021
  • 46 locations
None
Deployment o the Multidisciplinary Prospective Cohort Imminent

Immune-mediated inflammatory diseases (IMIDs) most often affect young patients and have high impact on morbidity and mortality with a significant alteration in the quality of life of patients with professional, social and emotional repercussions. Beyond this burden, IMIDs share many common pathophysiological mechanisms and treatments, known as "targeted therapies". Despite …

disease or disorder
  • 0 views
  • 24 May, 2021
  • 1 location
None
Complement C5a Receptors in Hidradenitis Suppurativa

To study the role of C5a in Hidradenitis Suppurativa (HS). Complement C5a is a major chemotactic factor that stimulates neutrophil infiltration.

hidradenitis
  • 51 views
  • 13 Feb, 2021
  • 1 location
None
Differential Diagnosis of Sj gren's Versus Non-Sj gren's Dry Eye

To investigate and compare the burden of dry eye in Sjgren's syndrome dry eye vs non-Sjgren's syndrome dry eye, as well as investigate the diagnostic potential of tear film mucins and various inflammatory cytokines evaluated by tear fluid analysis and impression cytology.

  • 0 views
  • 03 Feb, 2021
  • 1 location
None
The Pathogenesis and Natural History of Sjogren s Syndrome

Background -Sjogren s syndrome is a disease that affects about 1-4 million Americans. It is more common in women. It mainly affects the glands that produce saliva and tears, leading to dry eyes and dry mouth. The cause of Sjogren s syndrome is unknown, but inflammation plays an important role. …

vasculitis
keratoconjunctivitis sicca
fatigue
arthritis
dry eyes
  • 684 views
  • 21 Sep, 2021
  • 1 location