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Found 191 clinical trials
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A Phase 2a, Double-blind, Randomized, Placebo-controlled, Proof of Concept Study of Vascular Endothelial Growth Factor (VEGF)-B Blockade with the Monoclonal Antibody CSL346 in Subjects with Diabetic Kidney Disease.

We are currently recruiting participants for a clinical research study to evaluate the efficacy of an investigational medication in adults with Diabetic Kidney Disease.

diabetic chronic kidney disease
diabetic complication
diabetic complications
diabetes
hemoglobin a1c
  • 12 views
  • 17 May, 2021
  • 1 location
Study of Cabozantinib as 2nd Line Treatment in Subjects With Locally Advanced or Metastatic Renal Cell Carcinoma (RCC) With a Clear-Cell Component Who Progressed After 1st Line Treatment With Checkpoint Inhibitors

-cell component, who progressed after prior Checkpoint Inhibitors (CPI) therapy with ipilimumab and nivolumab in combination or CPI combined with Vascular Endothelial Growth Factor (VEGF)-targeted

  • 2 views
  • 05 Jun, 2021
  • 78 locations
Study of Apatinib as an Inhibitor of Tumor Angiogenesis

Apatinib is a tyrosin-inhibitor agent targeting at vascular endothelial growth factor receptor (VEGFR), so it can inhibit tumor angiogenesis. This phase I study aims to determine the

solid tumor
neutrophil count
mitomycin
growth factor
  • 0 views
  • 07 Nov, 2020
  • 1 location
25-G Vitrectomy With Ranibizumab or Triamcinolone Acetonide on PDR in China-Randomized Clinical Trial

Proliferative diabetic retinopathy(PDR) is the leading cause of visual loss in diabetic patients. Operation is an efficient method to treat PDR. Anti-vascular endothelial growth factor (anti

vascular endothelial growth factor
retinopathy
visual loss
vitrectomy
vitreous hemorrhage
  • 5 views
  • 22 Jan, 2021
  • 1 location
Treat-and-extend Using Aflibercept for Type 3 Neovascularization

-used, effective anti-vascular endothelial growth factor treatment regimen for neovascular AMD, regardless of subtypes of AMD. The purpose of the present study is to investigate the 18-month treatment

  • 0 views
  • 04 Mar, 2021
  • 1 location
Antiangiogenic Therapy With Bevacizumab in Retinopathy of Prematurity. Structural Outcome

blindness by suppressing the neovascular phase of ROP the visual outcomes after treatment are often poor. Vascular endothelial growth factor(VEGF) has an important role in the pathogenesis of ROP

vascular endothelial growth factor
bevacizumab
vegf
antiangiogenic therapy
blindness
  • 4 views
  • 07 Nov, 2020
  • 1 location
Intravitreal Conbercept Injection in Patients With Myopic Choroidal Neovascularization

-vascular endothelial growth factor (VEGF) drugs would significantly suppress the activity of the CNV and finally improve the visual acuity. However, more than half of the patients would need one or more

  • 0 views
  • 02 May, 2021
  • 1 location
Niraparib in Combination With Cabozantinib (XL184) in Patients With Advanced Urothelial Cancer (NICARAGUA)

Cabozantinib is an oral, small-molecule tyrosine kinase inhibitor. Its primary targets are Hepatocyte growth factor receptor protein (MET), vascular endothelial growth factor receptor 1-3

bladder cancer
RET
KIT
neutrophil count
advanced urothelial carcinoma
  • 46 views
  • 26 Jan, 2021
  • 12 locations
Modulation of Tissue Sodium in Hemodialysis Patients

dialysis session. Tissue Na+ mobilization correlated with circulating vascular endothelial growth factor-C (VEGF-C). The investigators believe that excessive Na+ storage is a reversible condition and

  • 9 views
  • 27 Jan, 2021
  • 1 location
Neoadjuvant CCRT With/Without Bevacizumab for Locally Advanced ESCC

. Therefore, investigators generate the hypothesis that adding vascular endothelial growth factor (VEGF) monoclonal antibody, Bevacizumab, to standard neoadjuvant CCRT may improve outcome for patients with

  • 0 views
  • 23 Jan, 2021
  • 1 location