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Found 5 clinical trials
A Multicenter, Randomized, Open-label, Phase 3 Trial Comparing Selpercatinib to Physicians Choice of Cabozantinib or Vandetanib in Patients With Progressive, Advanced, Kinase Inhibitor Naïve, RET-Mutant Medullary Thyroid Cancer (LIBRETTO-531) (LIBRETTO-531)

The reason for this study is to see if the study drug selpercatinib is safe and more effective compared to a standard treatment in participants with rearranged during transfection (RET)-mutant medullary thyroid cancer (MTC) that cannot be removed by surgery or has spread to other parts of the body. Participants …

vandetanib
cancer
progressive disease
metastasis
RET
  • 31 views
  • 20 Oct, 2022
  • 152 locations
Vandetanib and Everolimus in Treating Patients With Advanced or Metastatic Cancer

This phase I trial studies the side effects and best dose of vandetanib and everolimus when given together in treating patients with cancer that has spread to other places in the body

metastasis
absolute neutrophil count
neutrophil count
palliative radiation therapy
cancer
  • 0 views
  • 15 Jul, 2022
  • 1 location
A Phase I Dose Escalation Study for Patients With Recurrent Malignant Gliomas

the study is to find out the highest dose of vandetanib that can be safely given with repeat radiation therapy. Vandetanib will be called "study drug" in the remainder of this consent form

  • 7 views
  • 07 Nov, 2020
  • 1 location
Genomics-Based Target Therapy for Children With Relapsed or Refractory Malignancy

The purpose of this study is to evaluate the efficacy and feasibility of combination chemotherapy with target agents according to the result of targeted deep sequencing in pediatric patients with relapsed/refractory solid tumor or AML.

cytarabine
cancer
imatinib
etoposide
fludarabine
  • 0 views
  • 24 Jan, 2021
  • 1 location
Longitudinal Assessment and Natural History Study of Children and Adults With MEN2A or MEN2B With or Without Medullary Thyroid Carcinoma

Background Medullary thyroid cancer (MTC) is a rare cancer of the thyroid gland. In children and adults, it is often part of a condition called Multiple Endocrine Neoplasia 2 (MEN2). MEN2 is usually caused by a genetic mutation, and it can cause a number of problems in addition to MTC. …

Accepts healthy volunteers
  • 28 views
  • 24 Oct, 2022
  • 1 location