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Found 90 clinical trials
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ECOSPOR III: A Phase 3 Multicenter, RandomizeEd, Double Blind, Placebo COntrolled, Parallel Group Study to Evaluate the Safety, Tolerability, & Efficacy of SER-109 vs. Placebo to Reduce Recurrence of ClOstRidium Difficile Infection (CDI) in Adults

(Treatment Group I [SER-109] or Treatment Group II [Placebo]) and stratified by age (<65 years; ≥65 years), as well as antibiotic regimen for the qualifying episode (vancomycin; fidaxomicin).

antibiotics
antibiotic therapy
vancomycin
fidaxomicin
clostridium difficile
  • 1092 views
  • 21 Dec, 2020
  • 72 locations
featured
ECO-RESET: A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, Multicenter Study to Assess Efficacy and Safety of SER-287 in Adults with Active Mild-to-Moderate Ulcerative Colitis

To demonstrate the efficacy of study drug, SER-287, to induce clinical remission in patients with active mild-to-moderate ulcerative colitis.  

remission
corticosteroids
tumor necrosis factor
endoscopy
  • 219 views
  • 23 Nov, 2020
  • 1 location
Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection

The first line therapy for an initial episode of CDI (Clostridium difficile infection) is 10-14 days of oral vancomycin which is now recommended over metronidazole in the 2018 guidelines from

  • 0 views
  • 24 Jun, 2021
  • 1 location
Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA

The overall objective is to compare the effect of Vancomycin and Tobramycin powder combined (treatment) to Vancomycin powder (control) in the reduction of post-fixation infections of tibial

  • 0 views
  • 11 Jul, 2021
  • 1 location
Screening to Prophylax Against Clostridium Difficile Infection -

The goal of this study is to evaluate whether using vancomycin orally can prevent CDI in patients who are colonized with C. diff who are admitted to the hospital and need antibiotics for another

antibiotics
antibiotic therapy
ampicillin/sulbactam
vancomycin
clostridium difficile
  • 2 views
  • 01 Mar, 2021
  • 1 location
Preoperative Antibiotics for Carpal Tunnel Release Surgery

This is a clinical trial to determine how effective antibiotics administered prior to endoscopic carpal tunnel release surgery are in preventing surgical site infections.

carpal tunnel release
antibiotics
  • 21 views
  • 26 Jan, 2021
  • 1 location
C Difficile Near-patient Diagnostics

The investigators will conduct a two-period, two-intervention, cluster randomized crossover (CRXO) designed study at Foothills Hospital. Each cluster (hospital ward) will receive each of the two interventions in a separate 6-month period of time leading to two "cluster-periods" with associated "wash-in" and "wash-out" periods attached. The two interventions are: 1) …

  • 0 views
  • 23 Jan, 2021
  • 2 locations
Vancomycin for Primary Sclerosing Cholangitis

To find out if vancomycin is a safe and effective therapy for primary sclerosing cholangitis. Funding Source - FDA OOPD

vancomycin
colitis
cholangiography
obstruction
biliary obstruction
  • 27 views
  • 19 Jul, 2021
  • 4 locations
Topical Vancomycin Over Sternal Edge in Cardiac Surgery

This is a single-blind 1:1 randomized controlled trial based on the hypothesis that topical application of vancomycin paste over sternum edge is safe and can reduce sternal wound infection after

  • 0 views
  • 25 Jan, 2021
  • 1 location
Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficile

This study proposes to: Characterize the impact of oral vancomycin on C. difficile loads after end of treatment compared to a placebo group. Determine the effect of oral

oral vancomycin
vancomycin
diarrhea
vancomycin oral capsule
  • 6 views
  • 26 Jan, 2021
  • 1 location