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Found 403 clinical trials
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Heart Valve Disease – Aortic and Mitral

Study Description: Multi-center, international, prospective, randomized, interventional, pre-market study. Patients will be seen at pre and post-procedure, discharge, 30 days, 6 months, 1 year, 18 months, and annually through 10 years. Randomly assigned (50% to either group) Treatment of Aortic Stenosis with either Transcatheter Aortic Valve Replacement (TAVR) device or …

aortic valve replacement
stenosis
  • 776 views
  • 05 Feb, 2021
  • 1 location
featured
TRISCEND II

Patients suffering from heart failure not responsive to optimal medical therapy and who are diagnosed with tricuspid valve insufficiency should be considered for this pivotal clinical trial.

  • 0 views
  • 27 Apr, 2021
  • 1 location
featured
BRIDGE: Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for an Elective Invasive Procedure or Surgery

BRIDGE: Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for an Elective Invasive Procedure or Surgery

  • 30 views
  • 25 Mar, 2021
  • 1 location
Study of the Effect of the Benfluorex

More than 5 million persons in France exposed, in last years, to the taking of the Benfluorex. Arisen, at certain patients, of a valvulopathy characterized by mitrals and/or aortic leaks

  • 0 views
  • 26 Jan, 2021
  • 12 locations
Gene Therapy in Patients With Mucopolysaccharidosis Disease

This study investigated the safety and efficacy of gene therapy approaches for Mucopolysaccharidosis type VI disease caused by the deficiency of arylsulfatase B (ARSB) enzyme. The aim of the study is to evaluate the safety and efficacy of the treatment.

  • 1 views
  • 25 Jan, 2021
  • 3 locations
TRILUMINATE Pivotal Trial

The primary objective of this trial is to demonstrate the safety and effectiveness of the TriClip device in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR), who are at intermediate or greater estimated risk for mortality or morbidity with tricuspid valve surgery. This randomized controlled trial will …

mitral regurgitation
medical therapy
repair of tricuspid valve
fibrillation
regurgitation
  • 117 views
  • 02 Aug, 2021
  • 87 locations
Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes

Paravalvular regurgitation (PVR) is an important complication of Transcatheter Aortic Valve Implantation (TAVI) that is associated with a 2.5-fold increase risk of mortality. Transesophageal echocardiographic (TEE) is considered as the gold standard to assess the severity of PVR and guide the physician to perform corrective procedures during TAVI, but it …

symptomatic aortic stenosis
aortic valve stenosis
tavi
point-of-care testing
transcatheter aortic valve implantation
  • 0 views
  • 26 Jan, 2021
  • 1 location
Feasibility Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk

to evaluate the feasibility, safety and performance of the HighLife 28mm Transcatheter Mitral Valve in patients with moderate-severe or severe mitral regurgitation who are at high risk for surgical treatment.

heart surgery
medical therapy
mitral valve replacement
regurgitation
  • 68 views
  • 04 Jun, 2021
  • 32 locations
Treatment of Mitral Regurgitation Using a Minimally Invasive Approach With the HARPOON Device.

To evaluate the long-term safety and performance of the HARPOON MVRS for use in patients presenting with severe degenerative mitral regurgitation due to posterior leaflet prolapse in the post-market phase.

mitral valve disease
heart mitral valve
prolapse
regurgitation
mitral valve repair
  • 0 views
  • 23 Jul, 2021
  • 16 locations
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Repair System in patients with symptomatic severe tricuspid regurgitation who have been determined to be at an intermediate or greater estimated risk of mortality with tricuspid valve surgery by the cardiac surgeon with concurrence by the local Heart Team

medical therapy
tricuspid valve repair
regurgitation
heart failure
  • 10 views
  • 24 Jul, 2021
  • 34 locations