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Found 13 clinical trials
Neoadjuvant GMCI Plus Chemoradiation for Advanced Non-Metastatic Pancreatic Adenocarcinoma (PaTK02)

The purpose of this study is to evaluate Gene Mediated Cytotoxic Immunotherapy (GMCI) in combination with standard of care chemoradiation and surgery for borderline resectable and unresectable locally advanced pancreatic cancer in patients who have completed induction chemotherapy. GMCI kills tumor cells and creates an immune stimulatory environment in the …

tumor cells
metastatic pancreatic adenocarcinoma
neutrophil count
cancer
  • 0 views
  • 25 Jan, 2022
  • 4 locations
Zoster Eye Disease Study

This is a multi-center, randomized, double-masked, placebo-controlled clinical trial of suppressive valacyclovir for one year in immunocompetent study participants with an episode of dendriform

antiviral drugs
valacyclovir
vaccination
shingrix
rash
  • 780 views
  • 06 May, 2021
  • 85 locations
Valacyclovir for Mild Cognitive Impairment (VALMCI)

Anti-viral treatment in Mild Cognitive Impairment (MCI) is a Phase II, placebo-controlled, 52-week trial using oral valacyclovir 4 g/day in 50 HSV seropositive, AD biomarker-positive, amnestic

  • 108 views
  • 25 Jan, 2022
  • 1 location
Valacyclovir in Neonatal Herpes Simplex Virus Disease

This is an open-label, single center, pharmacokinetic (PK) study to assess valacyclovir pharmacokinetics and pharmacodynamics in neonates and compare to the pharmacokinetics and pharmacodynamics

  • 0 views
  • 01 Oct, 2021
  • 1 location
HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM

Study to assess the safety and efficacy of HSV-tk (gene therapy), valacyclovir, radiotherapy and chemotherapy in recurrent glioblastoma multiforme.

glioblastoma multiforme
anaplastic astrocytoma
aptt
MRI
cancer
  • 84 views
  • 26 Jan, 2021
  • 1 location
Using Oral Valacyclovir to Treat Patients With Refractory IC/BPS

-Barr virus (EBV) infection presented in the IC/BPS bladders and involved the pathogenesis. Hence, using anti-viral medication valacyclovir for the patients with IC/BPS might have clinical efficacy.

  • 15 views
  • 01 Nov, 2021
  • 1 location
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer

The purpose of this study is to conduct a Phase I - II clinical trial to extend preclinical studies involving in situ HSV-tk + Valacyclovir gene therapy in combination with brachytherapy for

metastasis
brachytherapy
external beam radiation therapy
recurrent prostate cancer
cancer
  • 17 views
  • 21 Jan, 2021
  • 1 location
Anti-viral Therapy in Alzheimer's Disease

Anti-viral therapy in Alzheimer's disease will investigate the efficacy of treating patients with mild Alzheimer's disease with the U.S.A marketed generic anti-viral drug Valtrex (valacyclovir

cholinesterase
mild cognitive impairment
positron emission tomography
dementia
amyloid
  • 95 views
  • 24 Jan, 2022
  • 3 locations
HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM

Study to assess the safety and efficacy of HSV-tk (gene therapy), valacyclovir, radiotherapy and chemotherapy in newly diagnosed glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA).

glioblastoma multiforme
anaplastic astrocytoma
aptt
cancer
platelet count
  • 32 views
  • 25 Jan, 2021
  • 1 location
Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies Radiotherapy & Surgery

This is a prospective phase II study to assess the efficacy and toxicity of HSV-tk+ valacyclovir gene therapy in combination with androgen deprivation therapy, brachytherapy, external beam

androgen suppression
metastasis
brachytherapy
androgens
adenocarcinoma of prostate
  • 3 views
  • 13 Apr, 2021
  • 1 location