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Found 17 clinical trials
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Do You Have Eye Disease From Shingles?

You may qualify for the Zoster Eye Disease Study (ZEDS) if you: had a rash from shingles over your eye have had certain types of eye disease from shingles a­ affecting your cornea within the past year are 18 years old or older  

  • 42 views
  • 23 Nov, 2020
  • 1 location
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer

The purpose of this study is to conduct a Phase I - II clinical trial to extend preclinical studies involving in situ HSV-tk + Valacyclovir gene therapy in combination with brachytherapy for

brachytherapy
cancer treatment
external beam radiation therapy
recurrent prostate cancer
cancer
  • 17 views
  • 08 Nov, 2020
  • 1 location
Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis

infectious epithelial keratitis, stromal keratitis,endotheliitis, or iridocyclitis. Patients will be enrolled to one of two treatment arms: Control arm: oral acyclovir 400 mg BID OR valacyclovir 500 mg daily

  • 5 views
  • 09 Mar, 2020
  • 1 location
30-Day Trial of Oral Valtrex or Valtrex Plus Aspirin on Shedding of HSV DNA in Tears and Saliva of Volunteers

The purpose of this study is to determine whether oral Valtrex alone or in combination with aspirin will reduce the shedding of herpes simplex virus DNA in the tears and saliva from volunteers with no evidence of ocular herpes infection. The secretion of virus into the tears and saliva might …

herpes infection
heart disease
valacyclovir
valtrex
herpes simplex virus dna
  • 1570 views
  • 07 Nov, 2020
  • 1 location
Neoadjuvant GMCI Plus Chemoradiation for Advanced Non-Metastatic Pancreatic Adenocarcinoma

The purpose of this study is to evaluate Gene Mediated Cytotoxic Immunotherapy (GMCI) in combination with standard of care chemoradiation and surgery for borderline resectable and unresectable locally advanced pancreatic cancer in patients who have completed induction chemotherapy. GMCI kills tumor cells and creates an immune stimulatory environment in the …

metastatic pancreatic adenocarcinoma
cancer
tumor cells
neutrophil count
  • 0 views
  • 16 Dec, 2020
  • 5 locations
Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus(EBV) related malignancy and is an endemic disease in Southeast Asian countries. EBV had been identified as a therapeutic target in some EBV related cancer such as lymphoma and NPC. In cancer cell, EBV was in latent phase and expressed 8-11 genes for maintaining …

carcinoma
metastatic nasopharyngeal carcinoma
nasopharyngeal carcinoma
valproic acid
recurrent nasopharyngeal carcinoma
  • 0 views
  • 08 Nov, 2020
  • 1 location
Zoster Eye Disease Study

This is a multi-center, randomized, double-masked, placebo-controlled clinical trial of suppressive valacyclovir for one year in immunocompetent study participants with an episode of dendriform

valacyclovir
  • 591 views
  • 20 May, 2020
  • 84 locations
Pharmacokinetics of Valacyclovir Oral Solution in Children

Valacyclovir has replaced acyclovir in many clinical scenarios. Pharmacokinetic data support the use of oral valacyclovir in children, but practical problems exist in children having to take

acyclovir
valacyclovir
  • 86 views
  • 14 Oct, 2020
  • 1 location
HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM

Study to assess the safety and efficacy of HSV-tk (gene therapy), valacyclovir, radiotherapy and chemotherapy in recurrent glioblastoma multiforme.

aptt
valacyclovir
cancer
platelet count
glioblastoma multiforme
  • 80 views
  • 14 Sep, 2020
  • 1 location
Should We Use Oral Valacyclovir in Acute Herpetic Gingivostomatitis in Children?

assess the clinical efficacy of oral Valacyclovir to decrease the duration of symptoms associated with acute herpes gingivostomatitis in children. This study will involve 80 children aged 1 to 8 years

valacyclovir
  • 0 views
  • 26 Oct, 2020
  • 1 location