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Found 9 clinical trials
Featured trial
Valacyclovir for Mild Cognitive Impairment (VALMCI)

Anti-viral treatment in Mild Cognitive Impairment (MCI) is a Phase II, placebo-controlled, 52-week trial using oral valacyclovir 4 g/day in 50 HSV seropositive, AD biomarker-positive, amnestic

  • 47 views
  • 08 Sep, 2022
  • 1 location
Neoadjuvant GMCI Plus Chemoradiation for Advanced Non-Metastatic Pancreatic Adenocarcinoma (PaTK02)

The purpose of this study is to evaluate Gene Mediated Cytotoxic Immunotherapy (GMCI) in combination with standard of care chemoradiation and surgery for borderline resectable and unresectable locally advanced pancreatic cancer in patients who have completed induction chemotherapy. GMCI kills tumor cells and creates an immune stimulatory environment in the …

metastatic pancreatic adenocarcinoma
tumor cells
cancer
neutrophil count
  • 0 views
  • 25 Jan, 2022
  • 4 locations
Zoster Eye Disease Study (ZEDS)

This is a multi-center, randomized, double-masked, placebo-controlled clinical trial of suppressive valacyclovir for one year in immunocompetent study participants with an episode of dendriform

shingrix
zoster vaccine
rash
vaccination
valacyclovir
  • 810 views
  • 14 Mar, 2022
  • 76 locations
Valacyclovir in Neonatal Herpes Simplex Virus Disease

This is an open-label, single center, pharmacokinetic (PK) study to assess valacyclovir pharmacokinetics and pharmacodynamics in neonates and compare to the pharmacokinetics and pharmacodynamics

  • 0 views
  • 07 Oct, 2022
  • 1 location
HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM

Study to assess the safety and efficacy of HSV-tk (gene therapy), valacyclovir, radiotherapy and chemotherapy in recurrent glioblastoma multiforme.

recurrent glioblastoma
astrocytoma, anaplastic
flair
glioblastoma multiforme
valacyclovir
  • 92 views
  • 05 Mar, 2022
  • 1 location
Should We Use Oral Valacyclovir in Acute Herpetic Gingivostomatitis in Children?

assess the clinical efficacy of oral Valacyclovir to decrease the duration of symptoms associated with acute herpes gingivostomatitis in children. This study will involve 80 children aged 1 to 8 years

valacyclovir
  • 0 views
  • 14 May, 2022
  • 1 location
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer

The purpose of this study is to conduct a Phase I - II clinical trial to extend preclinical studies involving in situ HSV-tk + Valacyclovir gene therapy in combination with brachytherapy for

metastasis
brachytherapy
recurrent prostate cancer
cancer treatment
cancer
  • 17 views
  • 21 Jan, 2021
  • 1 location
HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM

Study to assess the safety and efficacy of HSV-tk (gene therapy), valacyclovir, radiotherapy and chemotherapy in newly diagnosed glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA).

astrocytoma, anaplastic
glioblastoma multiforme
valacyclovir
platelet count
astrocytoma
  • 35 views
  • 05 Mar, 2022
  • 1 location
Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery

This is a prospective phase II study to assess the efficacy and toxicity of HSV-tk+ valacyclovir gene therapy in combination with androgen deprivation therapy, brachytherapy, external beam

metastasis
brachytherapy
adenocarcinoma of prostate
prostatectomy
androgens
  • 3 views
  • 15 Feb, 2022
  • 1 location