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Found 42 clinical trials
A Prospective Multi-center Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.

depressive symptoms
depressive episode
depressive disorder
  • 655 views
  • 05 Aug, 2021
  • 68 locations
Non-invasive Vagus Nerve Stimulation in Acute Ischemic Stroke

The main objective of the study will be to investigate whether treatment with non-invasive vagus nerve stimulation (nVNS) on top of best medical practice in acute ischemic stroke patients

stroke
probe
deficit
thrombectomy
infarct
  • 0 views
  • 25 Jan, 2021
  • 1 location
Brain Behavior and Endocrine Effects of Transcutaneous Vagus Nerve Stimulation

The main aim of the study is to investigate whether the transcutaneous vagus nerve stimulation(tVNS) promotes oxytocin release and the potential biomarkers of tVNS based on eye-tracking data

  • 0 views
  • 11 Jul, 2021
  • 1 location
Trial Comparing Different Stimulation Paradigms in Patients Treated With Vagus Nerve Stimulation for Refractory Epilepsy

Patients with refractory epilepsy who are candidates for a treatment with vagus nerve stimulation will be prospectively randomized into 3 arms with different vagus nerve stimulation

antiepileptics
seizure
vagus nerve stimulation
intractable epilepsy
  • 9 views
  • 07 Nov, 2020
  • 1 location
Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage

This is a single site, randomized, sham-controlled, double blinded pilot study assessing the feasibility, safety, tolerability, and efficacy of non-invasive VNS (nVNS), gammaCore, in the treatment of headache in subarachnoid hemorrhage (SAH). 40 participants will be enrolled, 20 in the active device arm and 20 in the sham arm. The …

  • 0 views
  • 27 Feb, 2021
  • 1 location
Transcranial Direct Current Stimulation (tDCS) As A Tool For Prospective Responder Identification Before Vagus Nerve Stimulation (VNS) Implantation

The aim of the study is to establish tDCS as a prognostic tool to predict VNS therapy outcome among patients with pharmacoresistant epilepsy.

epilepsy surgery
seizure
antiepileptics
vagus nerve stimulation
intractable epilepsy
  • 14 views
  • 07 Nov, 2020
  • 1 location
Mapping Auricular Vagus Nerve Circuitry

This study will determine how vagus nerve stimulation affects human brain, stomach, and autonomic activity.

  • 0 views
  • 24 Jan, 2021
Anti-inflammatory Actions of Osteopathic Manipulative Treatment

This study evaluates the hypothesis that osteopathic manipulative treatment (OMT) and non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) elicit anti-inflammatory actions

electrocardiogram
  • 67 views
  • 03 Feb, 2021
  • 1 location
Effect of Transcutaneous Electrical Auricular Stimulation of the Vagus Nerve in Kidney Transplant Recipients

alpha7 nicotinic acetylcholine receptor (alpha7nAChR) on macrophages by acetylcholine reduces production of multiple pro-inflammatory cytokines. Currently, vagus nerve stimulation is used to treat

  • 3 views
  • 25 Jan, 2021
  • 1 location
taVNS Paired With Bottle Feeding in Infants Failing Oral Feeds

Oromotor dysfunction and poor feeding is common after premature birth and hypoxic ischemic encephalopathy (HIE). Pairing vagus nerve stimulation (VNS) with motor activity accelerates functional

  • 0 views
  • 25 Mar, 2021
  • 1 location