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Found 1206 clinical trials
Featured trial
A Randomized Double-blind Placebo-controlled Parallel Group Study Assessing the Efficacy and Safety of Dupilumab in Patients With Allergic Fungal Rhinosinusitis (AFRS)  

Primary Objective: To evaluate the ability of dupilumab to reduce the need for rescue therapy with systemic corticosteroids (SCS) or surgery of AFRS in patients with AFRS who previously have had sino-nasal surgery Secondary Objectives: To evaluate the efficacy of treatment with dupilumab to reduce sinus opacification in a population …

  • 60 views
  • 09 Nov, 2022
  • 5 locations
Featured trial
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose Ranging Study to Assess the Efficacy, Safety, and Tolerability of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma (TIDE-asthma)  

This is a parallel, Phase 2, global, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, four-arms study for treatment. The purpose of this study is to assess the efficacy, safety, and tolerability of add-on therapy with amlitelimab in adult participants with moderate-to-severe asthma. Study details include: The study duration (per participant) will be …

  • 6 views
  • 17 Nov, 2022
  • 5 locations
Featured trial
Randomized, Open Label Phase 3 Study of SAR408701 Versus Docetaxel in Previously Treated Metastatic Non- Squamous Non-Small Cell Lung Cancer Patients With CEACAM5 Positive Tumors (CARMEN-LC03)  

Primary Objectives: Study is designed with two primary endpoints that will be analyzed on randomized participants at the time of the cutoff date for each given analysis (progression free survival [PFS] and overall survival [OS]). Study success is defined either on PFS or OS The primary objective is to determine …

  • 132 views
  • 17 Nov, 2022
  • 5 locations
Featured trial
Dupilumab in CRSsNP (Liberty CRSsNP ORION)  

Primary Objective: Part A and B: To evaluate the efficacy of dupilumab as assessed by the reduction at Week 24 in sinus opacification on computerized tomography (CT) scan and sinus total symptom score (sTSS) compared to placebo Secondary Objectives: Part A To evaluate the efficacy of dupilumab as assessed by …

antibiotics
nasal congestion
congestion
acute sinusitis
obstruction
  • 20 views
  • 09 Nov, 2022
  • 9 locations
Featured trial
Study to Evaluate the Efficacy and Safety of Venglustat in Adult and Pediatric Patients With Gaucher Disease Type 3 (LEAP2MONO)  

This is a parallel arm, Phase 3, double-blind, double-dummy, active-comparator, 2 arm study to evaluate the efficacy and safety of daily oral venglustat versus intravenous Cerezyme infusions every two weeks for improvement or stabilization of the neurological manifestations and maintenance of systemic disease stability in participants aged ≥12 and <18 …

neuronopathic gaucher disease
imiglucerase
bone pain
platelet count
alglucerase
  • 9 views
  • 18 Nov, 2022
  • 1 location
Featured trial
Influenza

, and quadrivalent influenza modRNA vaccine (qIRV), in participants 65 to 85 years of age. Participants will receive at Vaccination 1 either: 1 of 4 dose levels of mIRV (either A or B Strain), 1 of 4 dose

quadrivalent inactivated influenza vaccine
vaccination
strain
trivalent influenza vaccine
  • 27 views
  • 21 Apr, 2022
  • 1 location
Featured trial
Response to the HEPLISAV-B Hepatitis B Vaccine in Chronic Lymphocytic Leukemia (CLL) Patients that are Treatment Naive or Receiving Bruton s-tyrosine Kinase Inhibitor (BTK-I) Therapy

getting ibrutinib or acalabrutinib for it. Design: This study lasts 6 months from the date of first vaccination. Participants may be screened with:

ibrutinib
chronic lymphocytic leukemia
lymphoma
acalabrutinib
  • 67 views
  • 09 Apr, 2019
  • 1 location
Featured trial
PEDIATRIC VACCINES IN HEALTHY INFANTS AND TODDLERS (MENINGOCOCCAL CONJUGATE VACCINE)

MENINGOCOCCAL CONJUGATE VACCINE IS USED TO PREVENT INFECTION CAUSED BY MENINGOCOCCAL BACTERIA.  

conjugate vaccine
  • 10 views
  • 03 Oct, 2019
  • 1 location
Featured trial
Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) Patients that are Treatment Naive or Receiving Bruton s-Tyrosine Kinase Inhibitor (BTK-I) Therapy

Background: People who have cancer tend to get sick more often. This is in part because of the cancer treatments they get. Because of this, they may get shingles. Scientists had thought people with chronic lymphocytic leukemia (CLL) should not get the shingles vaccine. Now there is a new shingles …

acalabrutinib
ibrutinib
cancer
chronic lymphocytic leukemia
lymphoma
  • 238 views
  • 09 Apr, 2019
  • 1 location
Featured trial
Botulism Prevention

A Phase 2, multicenter, randomized, double-blinded, placebo-controlled study to evaluate repeat dose (50 mg and 100 mg) of G03-52-01 administered by IM injection(s) in adult subjects. Approximately 375 subjects will be enrolled in this study.

  • 0 views
  • 14 Jul, 2022
  • 1 location