Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 69 clinical trials
The Efficacy and Safety of ITF2357 in AIS

Autoinflammatory syndromes (AIS) are a group of disorders characterized by recurrent episodes of inflammation.Although for the hereditary autoinflammatory diseases the genetic mutations are known it remains largely unclear how these mutations lead to recurrent inflammatory attacks. Treatment of the inflammatory symptoms remains a challenge. With beneficial responses reported during treatment …

  • 5 views
  • 07 Nov, 2020
  • 1 location
A Phase III Study of Efficacy and Safety of Ligelizumab in the Treatment of CSU in Adolescents and Adults Inadequately Controlled With H1-antihistamines

The purpose of this study is to establish efficacy and safety of ligelizumab in adolescent and adult subjects with CSU who remain symptomatic despite standard of care treatment by demonstrating better efficacy over omalizumab. The study population will consist of approximately 1050 male and female subjects aged 12 years who …

antihistamines
a 12
urticaria
ligelizumab
omalizumab
  • 539 views
  • 28 Jan, 2021
  • 164 locations
A Phase III Study of Efficacy and Safety of Ligelizumab in the Treatment of CSU in Adolescents and Adults Inadequately Controlled With H1-antihistamines.

The purpose of this study is to establish efficacy and safety of ligelizumab in adolescent and adult subjects with CSU who remain symptomatic despite standard of care treatment by demonstrating better efficacy over omalizumab. The study population will consist of approximately 1050 male and female subjects aged 12 years who …

antihistamines
a 12
urticaria
ligelizumab
omalizumab
  • 614 views
  • 27 Jan, 2021
  • 196 locations
Dose-finding Study to Evaluate Efficacy and Safety of LOU064 in Patients With CSU Inadequately Controlled by H1-antihistamines

This is a multicenter, randomized, double-blind and placebo-controlled phase 2b dose-finding study to assess the efficacy and safety of LOU064 in adults chronic spontaneous urticaria (CSU

urticaria
treatment guidelines
antihistamines
  • 82 views
  • 27 Jan, 2021
  • 84 locations
Dupilumab for the Treatment of Chronic Spontaneous Urticaria in Patients Who Remain Symptomatic Despite the Use of H1 Antihistamine and Who Are na ve to Intolerant of or Incomplete Responders to Omalizumab

: omalizumab intolerant or incomplete responders) Secondary Objectives: To demonstrate the efficacy of dupilumab on urticaria activity composite endpoint and itch or hives, separately, at

h1 antihistamine
urticaria
dupilumab
angioedema
omalizumab
  • 10 views
  • 17 Feb, 2021
  • 81 locations
Open-label Multicenter Extension Study to Evaluate Long-term Safety and Tolerability of LOU064 in Subjects With CSU

This study is an open-label, single arm, multicenter, long-term safety and tolerability extension study for CSU patients who completed CLOU064A2201 or other preceding studies with LOU064

  • 0 views
  • 28 Jan, 2021
  • 57 locations
Study of Efficacy and Safety of Ligelizumab in Chronic Spontaneous Urticaria Patients Who Completed a Previous Study With Ligelizumab

The purpose of this extension study is to establish efficacy and safety of ligelizumab. This will be assessed in adult and adolescent chronic spontaneous urticaria (CSU) patients who have

urticaria
ligelizumab
antihistamines
  • 0 views
  • 28 Jan, 2021
  • 156 locations
A Study to Investigate the Use of Benralizumab in Patients With Chronic Spontaneous Urticaria Who Are Symptomatic Despite the Use of Antihistamines (ARROYO)

The purpose of this study is to investigate the use of benralizumab is effective in the treatment of chronic spontaneous urticaria (CSU) who are symptomatic despite the use of antihistamines.

  • 0 views
  • 18 Feb, 2021
  • 37 locations
Dupilumab in Chronic Spontaneous Urticaria

The purpose of this study is to assess the efficacy in reducing disease activity and safety of Dupilumab in adult patients with chronic spontaneous urticaria (CSU) who are symptomatic despite H1

urticaria
h1 antihistamine
antihistamines
dupilumab
  • 37 views
  • 23 Jan, 2021
  • 3 locations
Assessment of Suppression of Cutaneous Allergic Responses and Pruritus by Topical Doxycycline

Investigators will study the effects of topical doxycycline on cutaneous allergic early and late phase responses by determining allergen skin responses in each subject after a single application to allergen induced allergic swelling of 2% doxycycline in emollient.

asthma
allergen
swelling
aquaphor
  • 102 views
  • 23 Jan, 2021
  • 1 location