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Found 138 clinical trials
Cardiovascular Effects of Pulmonary Rehabilitation in COPD

Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction, which is clinically manifested by dyspnea and leads the patient to a vicious cycle of sedentary lifestyle. Pulmonary rehabilitation (PR) is an important therapeutic strategy to break this cycle. Cardiovascular diseases are frequent in patients with (COPD) and are …

dyspnea
obstruction
pulmonary rehabilitation
  • 3 views
  • 20 Apr, 2022
  • 1 location
Efficacy and Safety of Carvedilol in Cirrhosis Patients With Uncomplicated Ascites Without High Risk Esophageal Varices

The cumulative risk of refractory ascites is in the order of 20% within five years of the development of ascites. An elevated sinusoidal pressure is essential for the development of ascites, as fluid accumulation does not develop at portal pressure gradient below 8 mm Hg, and rising corrected sinusoidal pressure …

cytokines
paracentesis
carvedilol
esophageal varices
vasodilatation
  • 0 views
  • 06 Nov, 2021
  • 1 location
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations (BBESPB)

Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain. Development and implementation in clinical practice perioperative intensive care protocols for surgical correction of spinal deformities.

dexamethasone
bupivacaine
intubation
acute pain
chronic pain
  • 0 views
  • 20 Sep, 2022
  • 1 location
Targeted vs Standard Fortification of Breast Milk

BACKGROUND Human milk (HM) is recommended for all very low birth infants (VLBW)). Breast-milk is highly variable in nutrient content, failing to meet the nutritional demands of VLBW. Fortification of HM is recommended to prevent extra-uterine growth retardation and associated poor neurodevelopmental outcome. However, standard fortification with fixed dose multicomponent …

necrotizing enterocolitis
very low birth weight
bronchopulmonary dysplasia
prematurity
sepsis
  • 0 views
  • 26 Mar, 2022
  • 1 location
Bezlotoxumab Yielded Outcomes by Addressing Personalized Needs in Clostridioides Difficile Infection (BEYOND)

Previous data have shown that integrated information from single nucleotide polymorphisms (SNPs) of the host DNA, interleukin 8 (IL-8) and the enrichment of the stool microbiome can indicate the patients with infection by Clostridioides difficile (CDI) who are at risk for unfavorable outcome. This integrated information is forming the BEYOND …

  • 0 views
  • 26 May, 2022
  • 8 locations
Interest of Famotidine in Children With Sickle Cell Disease (FAMODREP)

The purpose of this study is to determine whether oral famotidine, a histamine type 2 receptor antagonist already widely used with very few side effects in other indications in children, is effective in reducing endothelial expression of P-selectin in children with sickle cell disease (SCD). This pilot study will constitute …

splenic sequestration
hydroxyurea
voxelotor
chest syndrome
priapism
  • 0 views
  • 15 Mar, 2022
Efficacy and Safety of EXOSOME-MSC Therapy to Reduce Hyper-inflammation In Moderate COVID-19 Patients (EXOMSC-COV19)

In COVID-19 infection caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a dysregulation of the immune system response that causes cytokine storm syndrome. SARS-CoV-2 works like a hijacker (hackers), sabotaging communication between cells so that the immune system, like T-cells, kills not only infected cells but …

  • 0 views
  • 26 Mar, 2022
The Effects of Sodium Phenylbutyrate on Circulating Branched Chain Amino Acids

The aim of this study is to reduce fasting circulating BCAA concentrations in volunteers using Sodium Phenylbutyrate. In addition, we aim investigate the effect of BCAA lowering on fasting blood glucose levels, insulin sensitivity measures and muscle metabolism.

  • 0 views
  • 08 Sep, 2021
  • 1 location
Effect of Dapagliflozin vs Sitagliptin on Liver Fat Accumulation and Body Composition in Patients With Diabetes Mellitus and Liver Transplantation (Dapa-LiT)

Patients with pre-transplantation type 2 diabetes (T2D) and new-onset diabetes post liver transplantation (NODAT) are managed with multiple doses of subcutaneous insulin (MSI) following liver transplantation. As these patients receive oral glucocorticoids (mostly prednisolone) and immunosuppressants, which elevate blood glucose levels, multiple doses of insulin are usually required. After 2-3 …

metformin
sitagliptin
hypoglycemic agents
oral hypoglycemic
insulin
  • 0 views
  • 24 Mar, 2022
  • 1 location
Oxalate and Citrate

This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones. For the first two days, subjects will eat a special diet at home, and on Days 3-5, they will eat …

Accepts healthy volunteers
  • 56 views
  • 16 May, 2022
  • 1 location