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Found 138 clinical trials
Construction and Effect Evaluation of Anticoagulation Management Model in Atrial Fibrillation (AMS-AF)

Study types and hypotheses: multicenter randomized controlled trials. This study predicts that standardized anticoagulation management of atrial fibrillation in primary health care institutions can reduce the prevalence of atrial fibrillation stroke by 50%. Formulation and revision of standardized anticoagulation management plan and process for atrial fibrillation in primary health care …

stroke
fibrillation
anticoagulant therapy
warfarin
anticoagulation therapy
  • 0 views
  • 25 Apr, 2022
  • 1 location
Pain and Anxiety During Transrectal Prostate Biopsy

Many studies have been conducted in the literature to manage pain and anxiety levels for patients undergoing transrectal prostate biopsy. In addition to the periprostatic block application recommended in the guidelines of the European Association of Urology, there are studies showing that TENS application or music applications will make an …

  • 0 views
  • 15 May, 2022
  • 1 location
Study to Compare PK & Safety of Advixa With Humira in Healthy, Adult Subject Followed by Efficacy & Safety Study in RA Patients (ACT)

Adalimumab is a recombinant monoclonal antibody (IgG1 subclass) against human TNF-α (Tumor Necrosis Factor-alpha). It is an immunosuppressive medication predominantly used to treat rheumatoid arthritis autoimmune disease. It is also used for the treatment of psoriatic arthritis, ankylosing spondylitis, and Crohn's disease etc. Adalimumab binds specifically to TNF-α and blocks …

adalimumab
ankylosing spondylitis
psoriatic arthritis
autoimmune disease
Accepts healthy volunteers
  • 0 views
  • 23 Jul, 2022
  • 1 location
Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy

The aim of this cross-over trial is to assess aliskiren, a direct renin inhibitor, as a novel treatment to block complement activation in the kidneys and thereby attenuate renal disease and stabilize or improve kidney function and compare it to the currently used treatment with the angiotensin converting enzyme inhibitor, …

mammogram
kidney biopsy
enzyme inhibitor
  • 17 views
  • 22 Mar, 2022
  • 1 location
Quizartinib and High-dose Ara-C Plus Mitoxantrone in Relapsed/Refractory AML With FLT3-ITD

In this multicenter, upfront randomized phase II trial, all patients receive quizartinib in combination with HAM (high-dose cytarabine, mitoxantrone) during salvage therapy. Efficacy is assessed by comparison to historical controls based on the matched threshold crossing approach. During consolidation therapy (chemotherapy as well as allo-HCT) patients receive either prophylactic quizartinib …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Clinical Efficacy of Megadose Vitamin C in Sepsis (CEMVIS)

In this multicenter, randomized, single-blind, placebo-controlled clinical trial. Patients will be randomly assigned to receive Vitamin C or placebo for 4 days or until ICU discharge (whatever come first). The primary outcome is 28-day all-cause mortality.

procalcitonin
  • 0 views
  • 06 Mar, 2022
  • 1 location
Comparison of BTD and BCD Based Regimens in the Treatment of AL Amyloidosis

Research Objective:At present, there is no standard therapeutic regimen for monoclonal immunoglobulin light chain (AL) amyloidosis in the world. To compare the efficacy and safety of the regimens between bortezomib-thalidomide-dexamethasone (BTD) and bortezomib-cyclophosphamide-dexamethasone (BCD) in the treatment of AL amyloidosis, so as to provide more clinical evidence for the standard …

bone marrow procedure
cyclophosphamide
dexamethasone
bortezomib
electrophoresis
  • 0 views
  • 26 Jan, 2021
  • 1 location
Early RRT in AKI After Cardiac Surgery

Acute kidney injury (AKI) is one of the major complications after cardiac surgery that may affects 20% to 40% of patients according to the definitions. Also, AKI after cardiac surgery is associated with high morbidity and mortality, with eight-fold increase in the odds ratio of death when renal replacement therapy …

renal replacement therapy
hemodiafiltration
  • 0 views
  • 13 Mar, 2022
  • 2 locations
Helicobacter Pylori Eradication Therapy in Portugal

Helicobacter pylori (H. pylori) infection remains a major public health problem, with an estimated prevalence of over 50% worldwide and 60-86% for Portugal. H. pylori is associated with significant morbidity and mortality from peptic ulcerative disease to gastric cancer, whose eradication therapy has proven to be effective in preventing these …

amoxicillin
urea
clarithromycin
antibiotics
breath test
  • 0 views
  • 25 Jul, 2022
  • 1 location
The Impact of Exercise / Stress Stimuli on HMB Supplementation Efficacy

The study aims at assessing the influence of β-hydroxy-β-methylbutyrate (HMB) free acid supplementation (90 mg/kg of fat free body mass/day) supplemented for 21 days on protein kinases activity and selected hormones levels, and subsequent improvements in muscle protein synthesis, lean body mass content and aerobic capacity.

Accepts healthy volunteers
  • 0 views
  • 25 Jul, 2022
  • 2 locations