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Found 140 clinical trials
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

, urea nitrogen), hepatic panel (alkaline phosphatase, ALT, AST, bilirubin total, and bilirubin direct), glucose, mineral panel (albumin, calcium, magnesium, phosphorus). C-reactive protein

fluoxetine
depressive episode
scid
depressed mood
depressive disorder
  • 3 views
  • 13 Jun, 2022
  • 1 location
Glutathione in Mild Cognitive Impairment

Elderly humans have an increased risk of dementia which begins as mild defects in memory called mild cognitive impairment. Glutathione (GSH), a key endogenous antioxidant has been linked to cognition. This exploratory study will investigate mechanisms linked to GSH for cognitive impairment (and improvement) by studying humans with mild cognitive …

dementia
antioxidants
  • 0 views
  • 25 Mar, 2022
  • 1 location
Dialysis-Less Frequently In The Elderly (D-LITE)

Thrice-weekly dialysis is the accepted standard of care for hemodialysis (HD) patients. Observational studies suggest that elderly HD patients do as well and have better quality of life with less dialysis (ie twice-weekly). We propose a single-center pilot study of 40 patients to determine the feasibility of a large randomized …

  • 0 views
  • 02 Jun, 2022
Amino Acid Bioavilability of Fava Beans

The goal of the project is to determine the ileal amino acid digestibility of Favabean in healthy subjects equipped with naso-ileal tube. For this purpose, Favabean will be intrinsically labelled with 15N using 15N fertilizer. This procedure will be realized in Finland and the labelled material will be sent to …

Accepts healthy volunteers
  • 0 views
  • 08 Nov, 2021
  • 1 location
Potassium Kinetic During and After Hemodialysis and Potassium Profiling to Prevent Arrhythmias

The primary objective of the study is the development of a mathematical model for predicting potassium kinetics during and after the dialytic session. The secondary objectives of the study are: the definition of a correlation between the kinetics of intra and extra-cellular concentrations of potassium during and after the dialytic …

electrocardiogram
  • 0 views
  • 25 Mar, 2021
  • 1 location
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome)

Rationale: Thyroid hormone (TH) is crucial for normal brain development. The transporter monocarboxlate transporter 8 (MCT8), located at various organs including brain neurons, is crucial for cellular transport of TH, mainly T3 . A defect in this transporter causes Allan-Herndon-Dudley syndrome (AHDS), which characterized by severe motor and cognitive retardation. …

  • 0 views
  • 30 Aug, 2021
  • 1 location
Preoperative Ultrasound-based Protocol for Optimization of Fluid Therapy to Prevent Early Intraoperative Hypotension

Background: Intraoperative hypotension increases 30-day mortality and the risks of myocardial injury and acute renal failure. Patients with inadequate volume reserve before the induction of anesthesia are highly exposed. The identification of latent hypovolemia is therefore crucial. Ultrasonographic measurement of the inferior vena cava collapsibility index (IVCCI) is able to …

elective surgery
  • 0 views
  • 25 Mar, 2022
Effect of Taurine on Glycemic, Lipid and Inflammatory Profile in Individuals With Type 2 Diabetes (TAUGLIP-DM2)

Type 2 diabetes mellitus (DM2) is characterized by chronic hyperglycemia, which is a risk factor for comorbidities and death. Although conventional pharmacotherapy is effective, some individuals do not reach the glycemic targets, requiring adjuvant therapies. Taurine is a semi-essential amino acid with antioxidant and osmoregulatory properties, commonly used as a …

  • 0 views
  • 23 Mar, 2022
ILTHPI - Comparison of Medicament Containing Tetracycline Metronidazole Bismuth Versus Amoxicillin Metronidazole Clarithromycin

Helicobacter pylori (H. pylori) is a spiral shaped, microaerophilic, gram negative bacterium. The organism resides in the acid and mucous layer of the human gastric mucosa, adheres to and colonizes the mucosal surface of the stomach and the mucosal epithelium with gastric metaplasia of duodenal bulb. Many studies have shown …

  • 0 views
  • 30 Apr, 2021
  • 1 location
68Ga-P16-093 and 68Ga-PSMA-11 PET/CT Imaging in the Same Group of Prostate Cancer Patients

Prostate-specific membrane antigen (PSMA)-targeted PET imaging with 68Ga-labeled compounds is able to provide superior sensitivity and specificity to detect primary prostate tumor and its metastases, like the most widely studied 68Ga-PSMA-11. This pilot study was prospectively designed to evaluate the diagnostic value of 68Ga-P16-093, a novel radiopharmaceutical targeting PSMA, which …

  • 0 views
  • 13 Jun, 2022
  • 1 location