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Found 137 clinical trials
COVID-19 and Hereditary Metabolic Diseases (COVID19-MHM)

diagnosed in a given group of IMD when the number of patients with this IMD is known (Urea Cycle Deficiency, Gaucher Disease). b. to evaluate the impact of IMD on the and severity of COVID-19 infection

  • 10 Mar, 2022
  • 1 location
Clinical Observation on Bone Metabolism Induced by Chronic Renal Insufficiency

Patients with chronic renal insufficiency usually develop secondary osteoporosis or bone loss, which is called renal osteodystrophy. Most of the previous studies focused on bone metabolism of patients in late stage of chronic renal insufficiency, especially those with chronic dialysis. In this study, bone metabolism of patients in different stages …

renal failure
chronic renal insufficiency
  • 30 Sep, 2021
  • 4 locations
Population Pharmacokinetic - Pharmacodynamic Models of Chronic Disease Therapeutics for Smokers

Purpose of study: Establishing population pharmacokinetic - pharmacodynamic models of chronic disease therapeutics for smoking patients to investigate the effects of gender, age, body weight, liver function, kidney function, nicotine, polycyclic aromatic hydrocarbon related metabolic enzymes and drug related metabolic enzymes gene polymorphism on steady-state drug concentration and efficacy in …

  • 22 Mar, 2022
  • 1 location
A Multicenter Observational Study on Safety of the Herbal Medicines at Inpatient Setting

Prospective observations on safety of the herbal medicines regarding liver and kidney injuries at inpatient setting of four sites in South Korea which are located at each quadrant of the country. In a previous study (PMID 28634823), six women presented liver injuries by herbs and similar findings were also reported. …

  • 21 Apr, 2022
Epidural Spinal Cord Stimulation for Hypertension in Patients With Neuropathic Pain

The purpose of the ESCAPE Study is to determine the extent to which epidural spinal cord stimulation (SCS) reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension. We also aim to determine the extent to which higher baseline BP (i.e., hypertension) predicts reductions in pain …

  • 03 Feb, 2021
  • 2 locations
Effect of Oxalate and Urate Metabolism on CKD Evolution

The current study primarily aimed to characterize the oxalate and uric acid metabolism in CKD patients and to analyze its association with renal survival prognosis. Secondarily, the study is planned to determine whether hyperoxalemia and hyperuricemia are independent risk factors for cardiovascular events and mortality.

chronic kidney disease, stage 1
Uric Acid Test
  • 24 Jan, 2021
  • 1 location
Link Between Eosinopenia and Bacterial Infections in the Elderly Subject Hospitalized in Geriatrics

The main purpose of this monocentric, non-interventional, prospective study carried out in acute geriatrics (UGA) and post-rehabilitation care, is to determine if eosinopenia is associated with bacterial infections.

  • 31 Dec, 2021
  • 1 location
The German ADPKD Tolvaptan Treatment Registry (AD(H)PKD)

The German ADPKD Tolvaptan Treatment Registry is a prospective, observational, multicentric study of patients suffering from ADPKD that are considered for tolvaptan treatment. All ADPKD patients that are evaluated for treatment indication, or that are planned to be treated with tolvaptan, or that are already treated with tolvaptan are eligible. …

  • 09 Jun, 2022
  • 10 locations
Opioid-Redox Study (ORS)

Side effects of opioids can from practical view be divided into short-term and long-term. Nervous system disorders are manifested by psychological status changes of the patient and may cause confusion, mental and somatic dependency, dizziness and so on. Influencing the vegetative and cardiovascular system hypotension can occur what is manifestation …

opioid agonist
  • 24 Feb, 2022
  • 1 location
Skeletal and Respiratory Muscle Strength, Pulmonary Function, Exercise Capacity and Physical Activity in Pediatric Chronic Kidney Disease

Studies examining musculoskeletal strength, respiratory function and muscle strength, physical activity level and exercise capacity in children with CKD and evaluating the relationships between these parameters have not been found both in the world and in our country. In this study, it is aimed to evaluate skeletal and respiratory muscle …

Accepts healthy volunteers
arterial stiffness
  • 12 May, 2022
  • 1 location