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Found 12 clinical trials
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A Randomized Trial of Pembrolizumab & Radiotherapy Versus Radiotherapy in High-Risk Soft Tissue Sarcoma of the Extremity

This is an open-label, multi-institutional phase II randomized study comparing neoadjuvant radiotherapy followed by surgical resection to neoadjuvant pembrolizumab with concurrent radiotherapy, followed by surgical resection and adjuvant pembrolizumab. The total duration of pembrolizumab will be one year in the experimental arm.

  • 56 views
  • 16 Jul, 2021
  • 18 locations
None
Focused Ultrasound to Promote Immune Responses for Undifferentiated Pleomorphic Sarcoma

This is a single arm, single site, feasibility study of Magnetic Resonance Guided Focused Ultrasound (MRgFUS) to promote immunotherapy responses in patients with undifferentiated pleomorphic

  • 0 views
  • 03 Jun, 2021
  • 1 location
None
Sintilimab for the Treatment of Locally Advanced Metastatic Recurrent or Unresectable Undifferentiated Pleomorphic Sarcoma SiARa Cancer Study

This phase II trial investigates the effects of sintilimab in treating patients with undifferentiated pleomorphic sarcoma that has spread to nearby tissue or lymph nodes (locally advanced

  • 0 views
  • 01 Sep, 2021
  • 1 location
None
ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma

patients with locally advanced, unresectable or metastatic undifferentiated pleomorphic sarcoma (UPS)/myxofibrosarcoma (MFS) who have progressed on one or two lines of chemotherapy.

  • 0 views
  • 17 Sep, 2021
  • 26 locations
None
Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma and Osteosarcoma

Phase I-II, randomized, open-label, multicenter, international clinical trial Patients with advanced soft-tissue sarcoma (undifferentiated pleomorphic sarcoma, leiomyosarcoma, alveolar soft-part

measurable disease
leiomyosarcoma
undifferentiated pleomorphic sarcoma
soft tissue sarcoma
gemcitabine
  • 0 views
  • 25 Nov, 2021
  • 7 locations
None
Itacitinib in Treating Patients With Refractory Metastatic/Advanced Sarcomas

This pilot phase I trial studies how well itacitinib works in treating patients with sarcomas that do not respond to treatment (refractory) and have spread to other parts of the body (advanced/metastatic). Itacitinib may cause changes in the immune system and the body's immune response to cancer, which may stop …

  • 10 views
  • 09 Jun, 2021
  • 1 location
None
Clinical and Biological Activity of an Anti-PD-L1 (Atezolizumab) in Operable Localised Soft Tissue Sarcomas Patients to be Treated With Radiotherapy

practice. Randomisation will be stratified according to histological subtypes as follows: Group 1: Liposarcoma (LPS), Undifferentiated Pleomorphic Sarcoma (UPS), Leiomyosarcoma (LMS

  • 8 views
  • 13 May, 2021
  • 6 locations
None
Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

This phase I trial studies the side effects of BO-112 when given together with nivolumab before surgery in treating patients with soft tissue sarcoma that can be removed by surgery (resectable). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere …

liposarcoma
fibrosarcoma
leiomyosarcoma
undifferentiated pleomorphic sarcoma
soft tissue sarcoma
  • 0 views
  • 28 Jun, 2021
  • 1 location
None
Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery

This phase II trial studies the side effects of talimogene laherparepvec and radiation therapy and to see how well they work in treating patients with newly diagnosed soft tissue sarcoma that can be removed by surgery. Biological therapies, such as talimogene laherparepvec, use substances made from living organisms that may …

liposarcoma
undifferentiated pleomorphic sarcoma
soft tissue sarcoma
leiomyosarcoma
sarcoma of the extremity
  • 16 views
  • 28 Nov, 2021
  • 10 locations
None
Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas

undifferentiated pleomorphic sarcoma and of the doxorubicin + dacarbazine + nivolumab combination in leiomyosarcoma. Treatment Cohort 7a dose level 0: Patients will receive

cancer chemotherapy
angiogenesis inhibitor
calcium
solitary fibrous tumor
mesna
  • 94 views
  • 26 Nov, 2021
  • 17 locations