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Found 134 clinical trials
Continuous Erector Spinae Block Versus Continuous Paravertebral Block

Overall Aim: To evaluate the efficacy of continuous erector spinae block (ESB) versus continuous paravertebral block (PVB) for postoperative analgesia in children and adolescents undergoing surgical procedures via unilateral thoracotomy. Hypothesis: The investigators hypothesize that ESP block efficacy is not inferior to that of PVB with respect to pain control …

analgesia
postoperative pain relief
thoracotomy
Accepts healthy volunteers
opiates
  • 0 views
  • 02 Feb, 2022
  • 1 location
Focal Laser Ablation for Benign Prostatic Hyperplasia

Efficacy of Ultrasound Guided Percutaneous Transperineal Laser Ablation in Benign Prostatic Hypertrophy Patients: Non-Pharmacological Interventional Study

benign prostatic hypertrophy
anesthesia
hypertrophy
dysuria
benign prostatic hyperplasia
  • 32 views
  • 14 Feb, 2022
  • 1 location
Comparison Elagolix vs Depot Leuprolide Prior to Frozen Embryo Transfers in Patients With Endometriosis

Patients who have been previously surgically diagnosed with endometriosis and have embryos predicted to be euploid after in vitro fertilization will be divided into 2 groups via randomization. The test group will receive Elagolix for 60 days prior to starting frozen embryo transfer preparation. The control group will be given …

leuprolide
elagolix
hormone antagonist
follicle stimulating hormone
gnrh antagonist
  • 53 views
  • 26 Jan, 2021
  • 1 location
Prenatal Treatment of Congenital Cytomegalovirus Infection With Letermovir Randomized Against Valaciclovir - STEP 1 (CYMEVAL3-STEP1)

In the model of the perfused cotyledon, Letermovir crosses the placenta to reach appropriate fetal concentration. The cotyledon model can only be performed in the third trimester placenta. Although it is probable that the transplacental passage in the second trimester is in the same range than the one found in …

Accepts healthy volunteers
  • 0 views
  • 27 Nov, 2021
  • 1 location
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations (BBESPB)

Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain. Development and implementation in clinical practice perioperative intensive care protocols for surgical correction of spinal deformities.

  • 0 views
  • 23 Apr, 2022
  • 1 location
PanDox: Targeted Doxorubicin in Pancreatic Tumours (PanDox)

This study will combine focused ultrasound to generate heat, and a heat-sensitive chemotherapy drug (ThermoDox®), delivered into the blood of participants with non-resectable pancreatic cancer. We will compare this to standard delivery of chemotherapy - the drug Doxorubicin given into the blood without the addition of ultrasound. We aim to …

  • 0 views
  • 14 Mar, 2022
  • 1 location
Continuous vs Liposomal Bupivacaine Interscalene Block for Proximal Humeral Fracture (CLIP)

Restricted range of shoulder motion following ORIF is a potential complication that severely affects the patients' functional outcome and should be actively avoided by means of adequate pain control in addition to early mobilization and physiotherapy. Peripheral nerve blocks, which can be given as a single injection or continuous infusion …

analgesia
humeral fracture
  • 0 views
  • 13 May, 2022
  • 2 locations
ESP vs QL for Total Abdominal Hysterectomy

Patients undergoing open total abdominal hysterectomy (n=82) at Parkland Memorial Hospital will be randomized into one of two groups to receive either ultrasound-guided bilateral ESP block with liposomal bupivacaine (Group 1) or ultrasound-guided bilateral QL block with liposomal bupivacaine (Group 2) for postoperative pain management. The remaining aspect of perioperative …

analgesia
Accepts healthy volunteers
anesthesia
breakthrough pain
postoperative pain
  • 1 views
  • 03 May, 2022
  • 1 location
Biologic Therapy to Prevent Osteoarthritis After ACL Injury

Anterior cruciate ligament (ACL) injuries are extremely common. On average, 50% of individuals suffering an ACL injury will develop radiographic osteoarthritis (OA) 10 to 20 years after injury. Unfortunately, ACL reconstruction does not prevent risk of future OA. Interleukin-1 (IL-1) levels in the human knee joint increase transiently after an …

Accepts healthy volunteers
  • 0 views
  • 30 Jun, 2022
  • 1 location
Uterine Transplant for Women With Absolute Uterine Factor Infertility (AUFI)

Absolute Uterine Factor Infertility (AUFI) is due to congenital or surgical absence of a uterus or the presence of a nonfunctional uterus. Until 2014, the only option for women affected by Absolute Uterine Factor Infertility (AUFI) was adoption or surrogate motherhood. Uterine transplant is a new form of transplant to …

  • 7 views
  • 30 Jun, 2022
  • 1 location