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Found 4 clinical trials
Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations

This BVD-523-ABC study builds on the safety and clinical activity experience of previous studies that have evaluated ulixertinib as a novel targeted cancer treatment in cohorts of patients with

  • 0 views
  • 04 Oct, 2022
  • 23 locations
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

palbociclib
tipifarnib
solid tumour
total body irradiation
brainstem tumor
  • 1032 views
  • 25 Oct, 2022
  • 108 locations
Ulixertinib (BVD-523) and Hydroxychloroquine in Patients w Advanced MAPK-Mutated Gastrointestinal Adenocarcinomas (UTAH)

Open-label dose escalation of Ulixertinib combined with fixed dose of hydroxychloroquine.

neutrophil count
liver metastasis
KRAS
absolute neutrophil count
cancer
  • 1 views
  • 13 Mar, 2022
  • 1 location
A Phase 2 Basket Trial of Ulixertinib (BVD-523) in Combination With Hydroxychloroquine in Patients With Advanced GI Malignancies Harboring Mitogen-activated Protein Kinase (MAPK) Pathway Mutations (BVD-523-HCQ)

This is an open-label, prospective phase two basket trial assessing the efficacy of ulixertinib in combination with hydroxychloroquine in patients with advanced gastrointestinal malignancies

BRAF
absolute neutrophil count
nab-paclitaxel
cancer
5-fluorouracil
  • 0 views
  • 21 Oct, 2022
  • 4 locations