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Found 462 clinical trials
Metabolic Responses to Bariatric Surgery

Research the genetic and biomechanical markers of human adipose tissue on patients with morbid obesity. Additional tissue/fluid collection is also gathered during the time of surgery.

dyslipidemia
diabetes
bariatric surgery
type 2 diabetes mellitus
  • 346 views
  • 26 Mar, 2022
  • 1 location
Understanding the Roles of Estradiol and Follicle-stimulating Hormone in Adipocyte Remodeling Following Surgical and Pharmacology-induced Menopause (RESUME-2 Study) (RESUME-2)

The overarching aims of this study are to: Characterize the rate of in vivo adipogenesis, and changes in adipose tissue gene and protein expression, in the scABD and scFEM depots of women undergoing surgical menopause (↓E2, ↑FSH). Characterize the rate of in vivo adipogenesis, and changes in adipose tissue gene …

fats
Accepts healthy volunteers
  • 0 views
  • 11 Oct, 2022
  • 1 location
Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations

Background PIDD stands for primary immune dysregulation. It is a general term that includes many different inherited immune system disorders. The immune system is the part of the body that helps fight disease and infection. People with PIDDs can develop many kinds of health problems. One of these is inflammatory …

urine tests
diarrhea
immune disorder
immunodeficiency
enteropathy
  • 13 views
  • 04 Oct, 2022
  • 1 location
Assessment of Anorectal Function in Patients With Inflammatory Bowel Disease

Active inflammatory bowel disease (IBD) causes disabling symptoms such as diarrhea, involuntary loss of bowel control, abdominal pain and urges to pass stool. However, even patients with inactive IBD frequently experience such symptoms. The cause is not well understood and the functionality of the bowel in IBD patients is underexplored. …

diarrhea
Accepts healthy volunteers
irritable bowel syndrome
anxiety
enteropathy
  • 0 views
  • 24 Mar, 2022
  • 1 location
Evaluation of Multi-Organ Metabolism and Perfusion in NAFLD by Total Body Dynamic PET Scan on EXPLORER (EXPLORER)

Evaluation of Multi-Organ Metabolism and Perfusion in Non-Alcoholic Fatty Liver Disease (NAFLD) by Total Body Dynamic PET Scan on EXPLORER

MRI
Accepts healthy volunteers
fatty liver
liver disease
blood test
  • 1 views
  • 18 Feb, 2022
  • 1 location
Identification Genetic Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung Disease

To identify demographic, clinical, genetic, immunologic and/or microbial (i.e., fecal stream characterization) risk factors that influence the likelihood of development of the HAEC phenotype in children who carry the diagnosis of HD. The newly formed HAEC Collaborative Research Group (HCRG) will utilize the 4 participating centers in the current consortia …

  • 85 views
  • 21 Jan, 2021
  • 1 location
A 24-month Real Life PErsistence Efficacy and Safety Study in IBD Patients in REMission Switched From Intravenous Infliximab to Subcutaneous Infliximab CT-P13 Remsima®SC (PEREM)

Descriptive: A 24-month multicentre, observational, prospective cohort study. Population: IBD Patients under stable clinical and biological remission Study treatments: Patients who will be proposed to switch, or who have just switched, from the intravenous originator Remicade® or one of its biosimilars to the subcutaneous infliximab Remsima®SC as part of routine …

remission
infliximab
methotrexate
azathioprine
biosimilar
  • 0 views
  • 04 Oct, 2022
  • 1 location
NGS in Gallbladder Cancer and Response to Treatment

Evidence suggests distinct models of molecular and pathologic progression, and a growing body of genetics data points to a heterogeneous collection of underlying mutations in key oncogenes and tumor suppressor genes. Although tumor genetics have been used to tailor individual treatment regimens and guide clinical decision making in other cancers, …

cancer
  • 0 views
  • 18 Jun, 2022
  • 1 location
Role of Pulmonary Perfusion on Tolerance to Supine Position in Patients With ARDS

The relationship between the presence or absence of endothelial dysfunction and changes in pulmonary perfusion will be evaluated, to then determine if there is any association between changes in the V / Q ratio and tolerance to the supine position after a prone cycle in patients with acute respiratory distress …

mechanical ventilation
acute respiratory distress
assisted breathing
  • 0 views
  • 15 Jun, 2022
  • 1 location
Microbiomes of Pelvic Pain

This research study seeks to provide more insight as to how the microbiome affects or is affected by conditions causing chronic pelvic pain such as Interstitial Cystitis (IC), Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS), Lower Urinary Tract Symptoms (LUTS), or Overactive bladder (OAB). Depression and many chronic pain disorders are …

pelvic pain
prostatitis
major depressive disorder
discomfort
pain disorders
  • 781 views
  • 16 Oct, 2022
  • 1 location