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Found 460 clinical trials
A Randomized, Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Vedolizumab Intravenous as Maintenance Therapy in Pediatric Subjects With Moderately to Severely Active Ulcerative Colitis Who Achieved Clinical Response Following Open-Label Vedolizumab Intravenous Therapy

Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe ulcerative colitis will be treated

pancolitis
tumour necrosis
methotrexate
tumor necrosis factor
endoscopy
  • 0 views
  • 19 Sep, 2022
  • 62 locations
The Efficacy and Safety of Cobitolimod in Participants With Moderate to Severe Active Left-Sided Ulcerative Colitis (CONCLUDE)

The purpose of the study is to evaluate the efficacy of cobitolimod treatment compared to placebo in inducing clinical remission, in participants with moderate to severe active left-sided UC and

left-sided ulcerative colitis
remission
  • 0 views
  • 04 Oct, 2022
  • 19 locations
Clinical Decision Support for Opioid Use Disorders in Medical Settings (COMPUTE 2.0)

-CDS intervention or usual care (UC). In intervention clinics, the OUD-CDS will identify patients who are at high risk for OUD or diagnosed with OUD; use data stored in the EHR for each eligible

  • 157 views
  • 08 Apr, 2022
  • 3 locations
Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer

This randomized phase III trial studies digital tomosynthesis mammography and digital mammography in screening patients for breast cancer. Screening for breast cancer with tomosynthesis mammography may be superior to digital mammography for breast cancer screening and may help reduce the need for additional imaging or treatment.

Accepts healthy volunteers
  • 2688 views
  • 02 Jul, 2022
  • 77 locations
Mental and Physical Well-Being of Frontline Health Care Workers During Coronavirus Disease 2019 (COVID-19) (COVER-HCW)

Study to support the mental and physical well-being of US health care workers during the COVID-19 pandemic and ensure high-quality care for patients through Stress First Aid.

Accepts healthy volunteers
  • 24 views
  • 16 Jun, 2022
  • 1 location
Metabolism Informed Smoking Treatment: The MIST RCT

This phase 3 randomized controlled trial will test Metabolism-Informed Smoking Treatment (MIST), a precision approach to smoking treatment that biologically tailors medication selection to nicotine metabolism.

  • 18 views
  • 04 Oct, 2022
  • 1 location
MS-20 on Patients With Ulcerative Colitis(UC)

This is a small pilot study of the fermented soybean extract MicrSoy-20(MS-20) to confirm its ability to improve UC severity with the treatment of standard therapies. The primary endpoint

microbiota
  • 0 views
  • 04 Jul, 2022
  • 1 location
Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis

The hypothesis of this study is that appropriate time of day of administration of oral, once daily 5-ASA therapy in alignment with the host circadian rhythms will improve subclinical inflammation and microbial structure/function and increase mucosal 5-ASA levels. All subjects will be randomized to once daily 5-ASA medications at two …

  • 0 views
  • 22 Mar, 2022
  • 1 location
Anal Manometry Examination in Patients With Ulcerative Colitis

Inflammatory bowel diseases (IBD), which include Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-related diseases. IBD symptoms frequently overlap with symptoms of

loperamide
crohn's disease
remission
  • 0 views
  • 04 Oct, 2022
  • 1 location
HCQ for Non Europeans With Mild to Severe UC

mild to severe Ulcerative Colitis (UC) and also to assess the immunological effects of hydroxychloroquine in this population. These outcomes will be evaluated both clinically and experimentally. In

endoscopy
mesalamine
remission
hematochezia
  • 0 views
  • 22 Jul, 2022
  • 3 locations